The pediatric cardiology pharmacopeia: 2013 update.

The use of medications plays a pivotal role in the management of children with heart diseases. Most children with increased pulmonary blood flow require chronic use of anticongestive heart failure medications until more definitive interventional or surgical procedures are performed. The use of such medications, particularly inotropic agents and diuretics, is even more amplified during the postoperative period. Currently, children are undergoing surgical intervention at an ever younger age with excellent results aided by advanced anesthetic and postoperative care. The most significant of these advanced measures includes invasive and noninvasive monitoring as well as a wide array of pharmacologic agents. This review update provides a medication guide for medical practitioners involved in care of children with heart diseases.

Suicide among Guaraní Kaiowá and Nandeva youth in Mato Grosso do Sul, Brazil.

Information on morbidity and mortality are critical for developing appropriate prevention and health promotion programs. This study summarizes data on the Guaraní (Kaiowá and Nandeva) communities in Mato Grosso do Sul, Brazil, about which little addressing suicide has been documented. Epidemiologic and anthropological data were used to examine suicidal behavior in these indigenous communities. Several findings in this report about the Guaraní Kaiowá and Nandeva communities were remarkable: the rates of suicide among these communities appear higher than the national average; suicide deaths disproportionately affect adolescents and young adults; and suicide rates among young males appear to be increasing. Data in this report highlight the need for health information data specific to a community in order to identify emerging health problems.

World Health Organization's TEACH-VIP: contributing to capacity building for youth violence prevention.

Youth violence is a major public health problem in every region of the world, yet it is especially prevalent in specific settings. Youth homicide rates exceeding 10.0/100,000 occur most often in countries that are low or middle income, or which are experiencing rapid economic or social change. Particularly in low- and middle-income countries, the capacity to develop and implement the comprehensive, multisectoral strategies to prevent youth violence is only just emerging. The prevention of youth violence requires multidisciplinary approaches and a variety of trained professionals. A public health approach to training in the area of injury prevention focuses on providing professionals and paraprofessionals a common understanding of essential skills and knowledge. One important benefit of this is that it addresses a major gap in current public health training that until recently has devoted relatively little attention to injury prevention. Another benefit is that it allows professionals from a variety of backgrounds to work together more effectively to reduce injury. This article will provide a broad overview of youth violence in low- and middle-income countries and will discuss the existing level of capacity within healthcare and public health sectors for responding to these problems. It concludes with a discussion of next steps for increasing capacity and a profile of the World Health Organization (WHO) training curriculum on injury and violence prevention called TEACH-VIP, an acronym for Training, Education, and Advancing Collaboration in Health on Violence and Injury Prevention, as one important effort undertaken by WHO and global injury partners to build capacity.

Does the sympathetic block outlast sensory block: a thermographic evaluation.

A study to evaluate the duration of sympathetic and sensory block in the L2 and L5 dermatome distributions using thermography and pinprick was conducted. Twenty patients received epidural block using 2% lidocaine with epinephrine. Onset and duration of the sensory and sympathetic blocks were determined and compared statistically. There was no difference between the duration of sensory and sympathetic block over the L2 dermatome, but sympathetic block was significantly longer than sensory block in the L5 dermatome. This study demonstrates that the duration of sympathetic block can be either longer or shorter than sensory block in L2 and L5 dermatomes. This has important implications for interpretation of results of differential epidural studies in that one cannot predict the duration of sympathetic block based on duration of sensory block.

Non-Toxigenic Penicillin and Cephalosporin-Resistant Corynebacterium diphtheriae Endocarditis in a Child: A Case Report and Review of the Literature.

Reports of invasive disease caused by non-toxigenic Corynebacterium diphtheriae are increasing; however, medical management has not been extensively studied. We describe what we believe is the first documented case of penicillin and cephalosporin-resistant C diphtheriae endocarditis in a child successfully treated with vancomycin, meropenem, and valvular replacement surgery.

Evaluation of pediatric near-infrared cerebral oximeter for cardiac disease.

BACKGROUND: Cerebral hypoxia-ischemia remains a complication in children with congenital heart disease. Near-infrared spectroscopy can be utilized at the bedside to detect cerebral hypoxia-ischemia. This study aimed to calibrate and validate an advanced technology near-infrared cerebral oximeter for use in children with congenital heart disease. METHODS: After institutional review board approval and parental consent, 100 children less than 12 years and less than 40 kg were enrolled. Phase I (calibration) measured arterial and jugular venous saturation (SaO(2), SjO(2)) by co-oximetry simultaneously with device signals to calibrate an algorithm to determine regional cerebral saturation against a weighted average cerebral saturation (0.7 SjO(2) + 0.3 SaO(2)). Phase II (validation) evaluated regional cerebral saturation from the algorithm against the weighted average cerebral saturation by correlation, bias, precision, and A(Root Mean Square) assessed by linear regression and Bland-Altman analysis. RESULTS: Of 100 patients, 86 were evaluable consisting of 7 neonates, 44 infants, and 35 children of whom 55% were female, 79% Caucasian, and 41% with cyanotic disease. The SaO(2) and regional cerebral saturation ranged from 34% to 100% and 34% to 91%, respectively. There were no significant differences in subject characteristics between phases. For the entire cohort, A(RMS), bias, precision, and correlation coefficient were 5.4%, 0.5%, 5.39%, and 0.88, respectively. Age, skin color, and hematocrit did not affect these values. CONCLUSIONS: This cerebral oximeter accurately measures the absolute value of cerebral saturation in children over a wide range of oxygenation and subject characteristics, offering advantages in assessment of cerebral hypoxia-ischemia in congenital heart disease.