Detalhe da pesquisa
1.
An age-progressive platelet differentiation path from hematopoietic stem cells causes exacerbated thrombosis.
Cell
; 2024 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38749423
2.
Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors.
Blood
; 142(14): 1233-1242, 2023 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37506345
3.
The oxylipin analog CS585 prevents platelet activation and thrombosis through activation of the prostacyclin receptor.
Blood
; 142(18): 1556-1569, 2023 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37624927
4.
The histone methyltransferase MLL1/KMT2A in monocytes drives coronavirus-associated coagulopathy and inflammation.
Blood
; 141(7): 725-742, 2023 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36493338
5.
Novel Strategy to Combat the Procoagulant Phenotype in Heparin-Induced Thrombocytopenia Using 12-LOX Inhibition.
Arterioscler Thromb Vasc Biol
; 43(10): 1808-1817, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37345522
6.
Loss of 12-Lipoxygenase Improves the Post-Transfusion Function of Stored Platelets.
Arterioscler Thromb Vasc Biol
; 43(10): 1990-2007, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37650322
7.
Investigating the catalytic efficiency of C22-Fatty acids with LOX human isozymes and the platelet response of the C22-oxylipin products.
Arch Biochem Biophys
; 747: 109742, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37696384
8.
Biochemical and hydrogen-deuterium exchange studies of the single nucleotide polymorphism Y649C in human platelet 12-lipoxygenase linked to a bleeding disorder.
Arch Biochem Biophys
; 733: 109472, 2023 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36442529
9.
GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force.
Proc Natl Acad Sci U S A
; 117(45): 28275-28286, 2020 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33097663
10.
Inhibitory Investigations of Acyl-CoA Derivatives against Human Lipoxygenase Isozymes.
Int J Mol Sci
; 24(13)2023 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37446119
11.
In Vitro Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase-2.
Biochemistry
; 60(22): 1741-1754, 2021 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34029049
12.
Platelet Signaling and Disease: Targeted Therapy for Thrombosis and Other Related Diseases.
Pharmacol Rev
; 70(3): 526-548, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29925522
13.
Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators.
Biochemistry
; 59(19): 1832-1844, 2020 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32324389
14.
Role of Human 15-Lipoxygenase-2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase-1.
Biochemistry
; 59(42): 4118-4130, 2020 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33048542
15.
15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5.
J Lipid Res
; 61(7): 1087-1103, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32404334
16.
Formation and Resolution of Pial Microvascular Thrombosis in a Mouse Model of Thrombotic Thrombocytopenic Purpura.
Arterioscler Thromb Vasc Biol
; 39(9): 1817-1830, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31340669
17.
KLF11 (Krüppel-Like Factor 11) Inhibits Arterial Thrombosis via Suppression of Tissue Factor in the Vascular Wall.
Arterioscler Thromb Vasc Biol
; 39(3): 402-412, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30602303
18.
Anti-inflammatory ω-3 endocannabinoid epoxides.
Proc Natl Acad Sci U S A
; 114(30): E6034-E6043, 2017 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28687674
19.
Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics.
Arterioscler Thromb Vasc Biol
; 38(7): 1632-1643, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29748334
20.
In vivo modeling of docosahexaenoic acid and eicosapentaenoic acid-mediated inhibition of both platelet function and accumulation in arterial thrombi.
Platelets
; 30(2): 271-279, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-29286871