Detalhe da pesquisa
1.
Amphipol-facilitated elucidation of the functional tetrameric complex of full-length cytochrome P450 CYP2B4 and NADPH-cytochrome P450 oxidoreductase.
J Biol Chem
; 296: 100645, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33839156
2.
The full-length cytochrome P450 enzyme CYP102A1 dimerizes at its reductase domains and has flexible heme domains for efficient catalysis.
J Biol Chem
; 293(20): 7727-7736, 2018 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29618513
3.
Formation of Both Heme and Apoprotein Adducts Contributes to the Mechanism-Based Inactivation of Human CYP2J2 by 17α-Ethynylestradiol.
Drug Metab Dispos
; 46(6): 813-822, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29602797
4.
Heme Modification Contributes to the Mechanism-Based Inactivation of Human Cytochrome P450 2J2 by Two Terminal Acetylenic Compounds.
Drug Metab Dispos
; 45(9): 990-999, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28698302
5.
Metabolism of Anandamide by Human Cytochrome P450 2J2 in the Reconstituted System and Human Intestinal Microsomes.
J Pharmacol Exp Ther
; 357(3): 537-44, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27000802
6.
Significant Improvement of Antithrombotic Responses to Clopidogrel by Use of a Novel Conjugate as Revealed in an Arterial Model of Thrombosis.
J Pharmacol Exp Ther
; 359(1): 11-7, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27511819
7.
Roles of Residues F206 and V367 in Human CYP2B6: Effects of Mutations on Androgen Hydroxylation, Mechanism-Based Inactivation, and Reversible Inhibition.
Drug Metab Dispos
; 44(11): 1771-1779, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27538916
8.
Oxidative hemoglobin reactions: Applications to drug metabolism.
Arch Biochem Biophys
; 600: 33-46, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27091316
9.
Hydroxylation and N-dechloroethylation of Ifosfamide and deuterated Ifosfamide by the human cytochrome p450s and their commonly occurring polymorphisms.
Drug Metab Dispos
; 43(7): 1084-90, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25934575
10.
Mechanism-Based Inactivation of Human Cytochrome P450 2B6 by Chlorpyrifos.
Chem Res Toxicol
; 28(7): 1484-95, 2015 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-26075493
11.
Role of the highly conserved threonine in cytochrome P450 2E1: prevention of H2O2-induced inactivation during electron transfer.
Biochemistry
; 52(27): 4636-47, 2013 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-23750736
12.
Potent mechanism-based inactivation of cytochrome P450 2B4 by 9-ethynylphenanthrene: implications for allosteric modulation of cytochrome P450 catalysis.
Biochemistry
; 52(2): 355-64, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23276288
13.
Formation, reactivity, and antiplatelet activity of mixed disulfide conjugates of clopidogrel.
Mol Pharmacol
; 83(4): 848-56, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23348501
14.
The inactivation of human CYP2E1 by phenethyl isothiocyanate, a naturally occurring chemopreventive agent, and its oxidative bioactivation.
Drug Metab Dispos
; 41(4): 858-69, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23371965
15.
The effect of ritonavir on human CYP2B6 catalytic activity: heme modification contributes to the mechanism-based inactivation of CYP2B6 and CYP3A4 by ritonavir.
Drug Metab Dispos
; 41(10): 1813-24, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23886699
16.
Interactions between CYP2E1 and CYP2B4: effects on affinity for NADPH-cytochrome P450 reductase and substrate metabolism.
Drug Metab Dispos
; 41(1): 101-10, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23043184
17.
Quantitation of UGT1A1 in human liver microsomes using stable isotope-labelled peptides and mass spectrometry based proteomic approaches.
Xenobiotica
; 43(4): 336-45, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22943130
18.
Oxidation of the endogenous cannabinoid arachidonoyl ethanolamide by the cytochrome P450 monooxygenases: physiological and pharmacological implications.
Pharmacol Rev
; 62(1): 136-54, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20133390
19.
Assay of Endocannabinoid Oxidation by Cytochrome P450.
Methods Mol Biol
; 2576: 317-327, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36152199
20.
Formation of the thiol conjugates and active metabolite of clopidogrel by human liver microsomes.
Mol Pharmacol
; 82(2): 302-9, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22584220