Detalhe da pesquisa
1.
PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals.
Cell
; 171(3): 628-641.e26, 2017 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29053969
2.
Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators.
Proc Natl Acad Sci U S A
; 120(25): e2218896120, 2023 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37327313
3.
Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors.
Blood
; 142(14): 1233-1242, 2023 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37506345
4.
Strikingly High Activity of 15-Lipoxygenase Towards Di-Polyunsaturated Arachidonoyl/Adrenoyl-Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death.
Angew Chem Int Ed Engl
; 63(9): e202314710, 2024 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38230815
5.
Investigating the catalytic efficiency of C22-Fatty acids with LOX human isozymes and the platelet response of the C22-oxylipin products.
Arch Biochem Biophys
; 747: 109742, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37696384
6.
Structural basis for altered positional specificity of 15-lipoxygenase-1 with 5S-HETE and 7S-HDHA and the implications for the biosynthesis of resolvin E4.
Arch Biochem Biophys
; 727: 109317, 2022 09 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-35709965
7.
In Vitro Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase-2.
Biochemistry
; 60(22): 1741-1754, 2021 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34029049
8.
A 12-lipoxygenase-Gpr31 signaling axis is required for pancreatic organogenesis in the zebrafish.
FASEB J
; 34(11): 14850-14862, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32918516
9.
Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
Bioorg Med Chem
; 46: 116349, 2021 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34500187
10.
Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators.
Biochemistry
; 59(19): 1832-1844, 2020 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32324389
11.
Role of Human 15-Lipoxygenase-2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase-1.
Biochemistry
; 59(42): 4118-4130, 2020 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33048542
12.
15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5.
J Lipid Res
; 61(7): 1087-1103, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32404334
13.
Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases.
Molecules
; 25(15)2020 Jul 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32722330
14.
N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice.
Ann Neurol
; 84(6): 854-872, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30294906
15.
Contributions of 12/15-Lipoxygenase to Bleeding in the Brain Following Ischemic Stroke.
Adv Exp Med Biol
; 1161: 125-131, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31562627
16.
5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1.
Biochemistry
; 57(48): 6726-6734, 2018 12 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30407793
17.
First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis.
Arterioscler Thromb Vasc Biol
; 37(10): 1828-1839, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28775075
18.
12(S)-HETrE, a 12-Lipoxygenase Oxylipin of Dihomo-γ-Linolenic Acid, Inhibits Thrombosis via Gαs Signaling in Platelets.
Arterioscler Thromb Vasc Biol
; 36(10): 2068-77, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27470510
19.
Strict Regiospecificity of Human Epithelial 15-Lipoxygenase-2 Delineates Its Transcellular Synthesis Potential.
Biochemistry
; 55(20): 2832-40, 2016 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-27145229
20.
Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase.
Biochemistry
; 55(23): 3329-40, 2016 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27226387