Detalhe da pesquisa
1.
Regioselective synthesis of N1-substituted-4-nitropyrazole-5-carboxylates via the cyclocondensation of ethyl 4-(dimethylamino)-3-nitro-2-oxobut-3-enoate with substituted hydrazines.
Org Biomol Chem
; 20(48): 9746-9752, 2022 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36444969
2.
A Stereocontrolled Synthesis of a Phosphorothioate Cyclic Dinucleotide-Based STING Agonist.
J Org Chem
; 86(13): 8851-8861, 2021 07 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34126006
3.
Conformational-Analysis-Guided Discovery of 2,3-Disubstituted Pyridine IDO1 Inhibitors.
ACS Med Chem Lett
; 12(7): 1143-1150, 2021 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34267885
4.
Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11ß-Hydroxysteroid Dehydrogenase Type 1 (11ß-HSD-1).
ACS Med Chem Lett
; 9(12): 1170-1174, 2018 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30613321
5.
Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists.
J Med Chem
; 61(3): 681-694, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29316397
6.
Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11ß-Hydroxysteroid Dehydrogenase Type 1 Inhibitor.
J Med Chem
; 60(12): 4932-4948, 2017 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28537398
7.
Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11ß-Hydroxysteroid Dehydrogenase Type 1 (11ß-HSD-1).
ACS Med Chem Lett
; 5(7): 803-8, 2014 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-25050169
8.
Discovery of 5-chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)-one (BMS-903452), an antidiabetic clinical candidate targeting GPR119.
J Med Chem
; 57(18): 7499-508, 2014 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25208139
9.
SAR of a novel 'Anthranilamide Like' series of VEGFR-2, multi protein kinase inhibitors for the treatment of cancer.
Bioorg Med Chem Lett
; 17(15): 4378-81, 2007 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17574417
10.
In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase.
Bioorg Med Chem Lett
; 14(12): 3155-9, 2004 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-15149665