Detalhe da pesquisa
1.
Comparative study of a novel selective urate reabsorption inhibitor "dotinurad" among patient groups with different stages of renal dysfunction.
Clin Exp Nephrol
; 25(12): 1336-1345, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34328574
2.
Uric acid-lowering effect of dotinurad, a novel selective urate reabsorption inhibitor, in hypertensive patients with gout or asymptomatic hyperuricemia: a pooled analysis of individual participant data in phase II and III trials.
Clin Exp Hypertens
; 43(8): 730-741, 2021 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34425059
3.
Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients.
Ann Rheum Dis
; 79(5): 657-665, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32238385
4.
A clinical pharmacology study of the novel, selective urate reabsorption inhibitor dotinurad in outpatients.
Clin Exp Nephrol
; 24(Suppl 1): 103-111, 2020 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-32067130
5.
A non-inferiority study of the novel selective urate reabsorption inhibitor dotinurad versus febuxostat in hyperuricemic patients with or without gout.
Clin Exp Nephrol
; 24(Suppl 1): 71-79, 2020 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-31970593
6.
Dotinurad versus benzbromarone in Japanese hyperuricemic patient with or without gout: a randomized, double-blind, parallel-group, phase 3 study.
Clin Exp Nephrol
; 24(Suppl 1): 62-70, 2020 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-31980978
7.
Clinical efficacy and safety of dotinurad, a novel selective urate reabsorption inhibitor, in Japanese hyperuricemic patients with or without gout: randomized, multicenter, double-blind, placebo-controlled, parallel-group, confirmatory phase 2 study.
Clin Exp Nephrol
; 24(Suppl 1): 53-61, 2020 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-31792640
8.
Open-label study of long-term administration of dotinurad in Japanese hyperuricemic patients with or without gout.
Clin Exp Nephrol
; 24(Suppl 1): 80-91, 2020 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-31875931
9.
Clinical efficacy and safety of dotinurad, a novel selective urate reabsorption inhibitor, in Japanese hyperuricemic patients with or without gout: an exploratory, randomized, multicenter, double-blind, placebo-controlled, parallel-group early phase 2 study.
Clin Exp Nephrol
; 24(Suppl 1): 44-52, 2020 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-31754882
10.
Effects of mild and moderate renal dysfunction on pharmacokinetics, pharmacodynamics, and safety of dotinurad: a novel selective urate reabsorption inhibitor.
Clin Exp Nephrol
; 24(Suppl 1): 17-24, 2020 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-31823130
11.
Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout.
Ann Rheum Dis
; 78(10): 1430-1437, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31289104
12.
Febuxostat Therapy for Patients With Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial.
Am J Kidney Dis
; 72(6): 798-810, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30177485
13.
Uric acid-lowering and renoprotective effects of topiroxostat, a selective xanthine oxidoreductase inhibitor, in patients with diabetic nephropathy and hyperuricemia: a randomized, double-blind, placebo-controlled, parallel-group study (UPWARD study).
Clin Exp Nephrol
; 22(4): 860-870, 2018 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-29372470
14.
Gender interaction of uric acid in the development of hypertension.
Clin Exp Hypertens
; 40(5): 446-451, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29182449
15.
Effect of Oral Alfacalcidol on Clinical Outcomes in Patients Without Secondary Hyperparathyroidism Receiving Maintenance Hemodialysis: The J-DAVID Randomized Clinical Trial.
JAMA
; 320(22): 2325-2334, 2018 12 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30535217
16.
GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes.
Ann Rheum Dis
; 76(5): 869-877, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27899376
17.
Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes.
Ann Rheum Dis
; 75(4): 652-9, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25646370
18.
Serum uric acid and the incidence of CKD and hypertension.
Clin Exp Nephrol
; 19(6): 1127-34, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25967597
19.
Apoptosis induced by an uromodulin mutant C112Y and its suppression by topiroxostat.
Clin Exp Nephrol
; 19(4): 576-84, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25239792
20.
Effects of febuxostat on serum urate level in Japanese hyperuricemia patients.
Mod Rheumatol
; 25(5): 779-83, 2015 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25671406