Detalhe da pesquisa
1.
Synthesis and evaluation of 2-amido-3-carboxamide thiophene CB2 receptor agonists for pain management.
Bioorg Med Chem Lett
; 22(7): 2604-8, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22370265
2.
Monosodium iodoacetate-induced joint pain is associated with increased phosphorylation of mitogen activated protein kinases in the rat spinal cord.
Mol Pain
; 7: 39, 2011 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-21599960
3.
Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and pharmacological magnetic resonance imaging.
J Pharmacol Exp Ther
; 328(1): 141-51, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18931146
4.
Indol-3-yl-tetramethylcyclopropyl ketones: effects of indole ring substitution on CB2 cannabinoid receptor activity.
J Med Chem
; 51(6): 1904-12, 2008 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-18311894
5.
1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction.
J Med Chem
; 49(17): 5093-109, 2006 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-16913699
6.
Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction.
J Med Chem
; 49(25): 7450-65, 2006 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17149874
7.
Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain.
J Med Chem
; 59(7): 3373-91, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27015369
8.
Role of central and peripheral mGluR5 receptors in post-operative pain in rats.
Pain
; 114(1-2): 195-202, 2005 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-15733645
9.
Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test.
Neuropsychopharmacology
; 30(7): 1257-68, 2005 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15688083
10.
2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist.
Neuropharmacology
; 49(1): 112-21, 2005 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15992586
11.
A-412997 is a selective dopamine D4 receptor agonist in rats.
Pharmacol Biochem Behav
; 82(1): 140-7, 2005 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16153699
12.
Central oxytocinergic and dopaminergic mechanisms regulating penile erection in conscious rats.
Pharmacol Biochem Behav
; 81(4): 797-804, 2005 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16005055
13.
Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction.
J Med Chem
; 47(15): 3853-64, 2004 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15239663
14.
YC-1 potentiates the nitric oxide/cyclic GMP pathway in corpus cavernosum and facilitates penile erection in rats.
Eur J Pharmacol
; 458(1-2): 183-9, 2003 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12498924
15.
A-350619: a novel activator of soluble guanylyl cyclase.
Life Sci
; 72(9): 1015-25, 2003 Jan 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-12495780
16.
Estimating efficacy and drug ED50's using von Frey thresholds: impact of weber's law and log transformation.
J Pain
; 13(6): 519-23, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22543045
17.
Pharmacological characterization of A-960656, a histamine H3 receptor antagonist with efficacy in animal models of osteoarthritis and neuropathic pain.
Eur J Pharmacol
; 684(1-3): 87-94, 2012 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-22504024
18.
Central and peripheral sites of action for CB2 receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats.
Br J Pharmacol
; 162(2): 428-40, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20880025
19.
Antinociceptive effects of histamine H3 receptor antagonist in the preclinical models of pain in rats and the involvement of central noradrenergic systems.
Brain Res
; 1354: 74-84, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20682302
20.
Diaryldiamines with dual inhibition of the histamine H(3) receptor and the norepinephrine transporter and the efficacy of 4-(3-(methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in pain.
J Med Chem
; 53(21): 7869-73, 2010 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20945906