Detalhe da pesquisa
1.
Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production.
Cell
; 159(7): 1549-62, 2014 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-25525874
2.
Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis.
Cell
; 152(3): 519-31, 2013 Jan 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-23374347
3.
Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis.
PLoS Biol
; 22(5): e3002617, 2024 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38696533
4.
FOXA2 activates HIF2α expression to promote tumor progression and is regulated by the E3 ubiquitin ligase VHL in renal cell carcinoma.
J Biol Chem
; 300(1): 105535, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38072043
5.
Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia.
Blood
; 141(6): 634-644, 2023 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36219880
6.
Clonal hematopoiesis, myeloid disorders and BAX-mutated myelopoiesis in patients receiving venetoclax for CLL.
Blood
; 139(8): 1198-1207, 2022 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34469514
7.
Single-cell multiomics reveal the scale of multilayered adaptations enabling CLL relapse during venetoclax therapy.
Blood
; 140(20): 2127-2141, 2022 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35709339
8.
The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase.
Biochem J
; 480(9): 665-684, 2023 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37115711
9.
BCL2 and MCL1 inhibitors for hematologic malignancies.
Blood
; 138(13): 1120-1136, 2021 09 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34320168
10.
Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias.
Blood
; 137(20): 2721-2735, 2021 05 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33824975
11.
Transcriptional silencing of fetal hemoglobin expression by NonO.
Nucleic Acids Res
; 49(17): 9711-9723, 2021 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34379783
12.
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models.
Nature
; 538(7626): 477-482, 2016 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27760111
13.
Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53.
Genes Dev
; 28(1): 58-70, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24395247
14.
A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis.
Nat Chem Biol
; 15(11): 1057-1066, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31591564
15.
A cluster of interferon-γ-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii.
Immunity
; 37(2): 302-13, 2012 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-22795875
16.
The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments.
Immunity
; 36(4): 646-57, 2012 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22483802
17.
Infection with flaviviruses requires BCLXL for cell survival.
PLoS Pathog
; 14(9): e1007299, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30261081
18.
IMiDs prime myeloma cells for daratumumab-mediated cytotoxicity through loss of Ikaros and Aiolos.
Blood
; 132(20): 2166-2178, 2018 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30228232
19.
CARM1-mediated methylation of protein arginine methyltransferase 5 represses human γ-globin gene expression in erythroleukemia cells.
J Biol Chem
; 293(45): 17454-17463, 2018 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30257864
20.
Clinicopathological features and outcomes of progression of CLL on the BCL2 inhibitor venetoclax.
Blood
; 129(25): 3362-3370, 2017 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28473407