High-Energy Symmetric Li-Ion Battery Enabled by Binder-Free FeOF-MXene Heterostructure with Doubly Matched Capacity and Kinetics.

Fluorides are viewed as promising conversion-type Li-ion battery cathodes to meet the desired high energy density. FeOF is a typical member of conversion-type fluorides, but its major drawback is sluggish kinetics upon deep discharge. Herein, a heterostructured FeOF-MXene composite (FeOF-MX) is demonstrated to overcome this limitation. The rationally designed FeOF-MX electrode features a microsphere morphology consisting of closely packed FeOF nanoparticles, providing fast transport pathways for lithium ions while a continuous wrapping network of MXene nanosheets ensures unobstructed electron transport, thus enabling high-rate lithium storage with enhanced pseudocapacitive contribution. In/ex situ characterization techniques and theoretical calculations, both reveal that the lithium storage mechanism in FeOF arises from a hybrid intercalation-conversion process, and strong interfacial interactions between FeOF and MXene promote Li-ion adsorption and migration. Remarkably, through demarcating the conversion-type reaction with a controlled potential window, a symmetric full battery with prelithiated FeOF-MX as both cathode and anode is fabricated, achieving a high energy density of 185.5 Wh kg-1 and impressive capacity retention of 88.9% after 3000 cycles at 1 A g-1. This work showcases an effective route toward high-performance MXene engineered fluoride-based electrodes and provides new insights into constructing symmetric batteries yet with high-energy/power densities.

Promoting CO2 Electroreduction Over Nano-Socketed Cu/Perovskite Heterostructures via A-Site-Valence-Controlled Oxygen Vacancies.

Despite the intriguing potential, nano-socketed Cu/perovskite heterostructures for CO2 electroreduction (CO2RR) are still in their infancy and rational optimization of their CO2RR properties is lacking. Here, an effective strategy is reported to promote CO2-to-C2+ conversion over nano-socketed Cu/perovskite heterostructures by A-site-valence-controlled oxygen vacancies. For the proof-of-concept catalysts of Cu/La0.3-xSr0.6+xTiO3-δ (x from 0 to 0.3), their oxygen vacancy concentrations increase controllably with the decreased A-site valences (or the increased x values). In flow cells, their activity and selectivity for C2+ present positive correlations with the oxygen vacancy concentrations. Among them, the Cu/Sr0.9TiO3-δ with most oxygen vacancies shows the optimal activity and selectivity for C2+. And relative to the Cu/La0.3Sr0.6TiO3-δ with minimum oxygen vacancies, the Cu/Sr0.9TiO3-δ exhibits marked improvements (up to 2.4 folds) in activity and selectivity for C2+. The experiments and theoretical calculations suggest that the optimized performance can be attributed to the merits provided by oxygen vacancies, including the accelerated charge transfer, enhanced adsorption/activation of reaction species, and reduced energy barrier for C─C coupling. Moreover, when explored in a membrane-electrode assembly electrolyzer, the Cu/Sr0.9TiO3-δ catalyst shows excellent activity, selectivity (43.9%), and stability for C2H4 at industrial current densities, being the most effective perovskite-based catalyst for CO2-to-C2H4 conversion.

Anti-carbamylated protein antibodies drive AEC II toward a profibrotic phenotype by interacting with carbamylated TLR5.

OBJECTIVES: This study was to explore the role of Anti-carbamylated protein (Anti-CarP) antibodies in contributing to lung fibrosis in connective tissue disease (CTD)-associated interstitial lung disease (ILD) in an autoantigen-dependent manner. METHODS: ELISA tested serum samples, including 89 of CTD-ILD group and 170 of non-ILD CTD, for the anti-CarP levels. Male C57BL/6 mice were used for pulmonary fibrosis model and anti-CarP treatment in vivo (n = 5), and patient serum-derived or commercialized anti-CarP for cell treatment. We identified the carbamylated membrane protein via immunofluorescence (IF) and coimmunoprecipitation followed by mass spectrometry (MS) analysis. RT-qPCR, IF and western blot were performed to explore the antigen-dependent role of anti-CarP. Native electrophoretic mobility shift assay and MS analysis were used to verify direct interaction and carbamylation sites. RESULTS: A significantly higher serum anti-CarP level was observed in CTD with ILD than without ILD. In vivo, intrapulmonary delivery of anti-CarP induces epithelial-mesenchymal transition (EMT) and micro fibrotic foci. Carbamylation was enriched in type II alveolar epithelial cells (AEC II). A novel carbamylated membrane receptor, specifically recognized by anti-CarP, was identified as toll-like receptor 5 (TLR5). We found anti-CarP induces the nuclear translocation of NF-κB and downstream events, including EMT and expression of inflammatory cytokines in AEC II, which were reversed by TLR5 blocking or TLR5 knockdown. Moreover, up to 12 lysine carbamylation sites were found in TLR5 ectodomain, allowing the interaction of anti-CarP with carbamylated TLR5. CONCLUSIONS: Overall, we found anti-CarP drives aberrant AEC II activation by interacting with carbamylated TLR5 to promote ILD progress.

Interpretable Data-Driven Descriptors for Establishing the Structure-Activity Relationship of Metal-Organic Frameworks Toward Oxygen Evolution Reaction.

The development of readily accessible and interpretable descriptors is pivotal yet challenging in the rational design of metal-organic framework (MOF) catalysts. This study presents a straightforward and physically interpretable activity descriptor for the oxygen evolution reaction (OER), derived from a dataset of bimetallic Ni-based MOFs. Through an artificial-intelligence (AI) data-mining subgroup discovery (SGD) approach, a combination of the d-band center and number of missing electrons in eg states of Ni, as well as the first ionization energy and number of electrons in eg states of the substituents, is revealed as a gene of a superior OER catalyst. The found descriptor, obtained from the AI analysis of a dataset of MOFs containing 3-5d transition metals and 13 organic linkers, has been demonstrated to facilitate in-depth understanding of structure-activity relationship at the molecular orbital level. The descriptor is validated experimentally for 11 Ni-based MOFs. Combining SGD with physical insights and experimental verification, our work offers a highly efficient approach for screening MOF-based OER catalysts, simultaneously providing comprehensive understanding of the catalytic mechanism.

The Structure, Preparation, Characterization, and Intercalation Mechanism of Layered Hydroxides Intercalated with Guest Anions.

Since the intercalation of anions into layered hydroxides (LHs) has a great impact not only on their nucleation and growth but also on their structure, composition, and size, the intercalation chemistry of LHs has aroused the strong interest of researchers. However, the progress in the fundamental understanding of LHs intercalated with guest anions have not been paralleled by a concomitant development of the preparation and performance improvement of such materials. Considering the guidance of a timely in-depth review for scientists in this area, a systematic introduction about the development that is made on the above-mentioned issues is highly needed but yet missing so far. Herein, recent advances in understanding the chemical composition and structure of LHs intercalated with guest anions are systematically summarized. Meanwhile, typical and emerging bottom-up synthesis methods of LHs intercalated with anions are reviewed, and the potential impact of external reaction parameters on the intercalation of anions into LHs are discussed . Besides, different analytical characterization techniques employed in the examination of guest anion-intercalated LHs are deliberated upon. Finally, although progress is slow in exploring the intercalation mechanism, as many examples as possible are included in this review and inferred the possible intercalation mechanism.

Toward Understanding the Formation Mechanism and OER Catalytic Mechanism of Hydroxides by In Situ and Operando Techniques.

Developing efficient and affordable electrocatalysts for the sluggish oxygen evolution reaction (OER) remains a significant barrier that needs to be overcome for the practical applications of hydrogen production via water electrolysis, transforming CO2 to value-added chemicals, and metal-air batteries. Recently, hydroxides have shown promise as electrocatalysts for OER. In situ or operando techniques are particularly indispensable for monitoring the key intermediates together with understanding the reaction process, which is extremely important for revealing the formation/OER catalytic mechanism of hydroxides and preparing cost-effective electrocatalysts for OER. However, there is a lack of comprehensive discussion on the current status and challenges of studying these mechanisms using in situ or operando techniques, which hinders our ability to identify and address the obstacles present in this field. This review offers an overview of in situ or operando techniques, outlining their capabilities, advantages, and disadvantages. Recent findings related to the formation mechanism and OER catalytic mechanism of hydroxides revealed by in situ or operando techniques are also discussed in detail. Additionally, some current challenges in this field are concluded and appropriate solution strategies are provided.

Revealing the Formation Mechanism and Optimizing the Synthesis Conditions of Layered Double Hydroxides for the Oxygen Evolution Reaction.

Layered double hydroxides (LDHs), whose formation is strongly related to OH- concentration, have attracted significant interest in various fields. However, the effect of the real-time change of OH- concentration on LDHs' formation has not been fully explored due to the unsuitability of the existing synthesis methods for in situ characterization. Here, the deliberately designed combination of NH3 gas diffusion and in situ pH measurement provides a solution to the above problem. The obtained results revealed the formation mechanism and also guided us to synthesize a library of LDHs with the desired attributes in water at room temperature without using any additives. After evaluating their oxygen evolution reaction performance, we found that FeNi-LDH with a Fe/Ni ratio of 25/75 exhibits one of the best performances so far reported.

Protective effect of transient receptor potential melastatin 2 inhibitor A10 on oxygen glucose deprivation/reperfusion model.

:To investigate the effect of transient receptor potential melastatin 2 （TRPM2） inhibitor A10 on oxygen glucose deprivation/reperfusion （OGD/R） injury in SH-SY5Y cells．:Human neuroblastoma SH-SY5Y cells were subject to OGD/R injury，and then were divided into blank control group，model control group and A10 group randomly. The cell survival rate was detected by cell counting kit 8 （CCK-8）; the level of cellular reactive oxygen species （ROS） was detected by reactive oxygen detection kit; the mitochondrial membrane potential was detected by tetramethylrhodamine （TMRM） method; the number of apoptotic cells was detected by TUNEL apoptosis assay kit; the protein expression level of cleaved caspase 3 was detected by Western blot．:Compared with 3，20，30，50， has lower cytotoxicity and better inhibition effect on channel activity. Compared with the model control group，ROS level was reduced，the mitochondrial membrane potential was improved，the number of apoptosis cells was reduced ，and the expression of cleaved caspase 3 was significantly reduced in the A10 group（all <0.05）. : A10 can alleviate cell damage after OGD/R by inhibiting TRPM2 channel function，reducing extracellular calcium influx，reducing cell ROS levels，stabilizing mitochondrial membrane potential levels，and reducing apoptosis.

Multifunctional Nickel Sulfide Nanosheet Arrays for Solar-Intensified Oxygen Evolution Reaction.

Electrochemical water splitting for hydrogen production is currently hindered by the sluggish kinetic of anodic oxygen evolution reaction (OER). By integrating photothermal materials into electrocatalytic network and thus allowing solar energy to work as additional driving force, the OER is expected to be boosted. However, the rational design of such electrochemical system still remains a challenge due to the spatial inconsistency between photothermal component and electrocatalytic component. Herein, it is reported that multifunctional nickel sulfide (Ni3 S2 ) nanosheet arrays show both photothermal and electrocatalytic properties for solar-intensified electrocatalytic system, which well eliminates the spatial inconsistency between the aforementioned two types of functional components by using one bifunctional material. The deliberate design of nanoarray architecture formed by the interconnected Ni3 S2 nanosheets endows larger surface area and higher surface roughness, thus enhancing light absorption by suppressing diffuse reflection and facilitating electron transfer in electrocatalytic reactions. Therefore, the OER activity is significantly improved. Under light illumination, the current density of Ni3 S2 nanosheets could reach 492.2 mA cm-2 at 1.55 V, about 2.5-fold that in dark conditions, with a Tafel slope of as low as 60 dec-1 . The solar-intensified electrochemical system based on multifunctional material presents prospective potential in electrochemical water splitting for efficient hydrogen production.

Facile Synthesis of Size-Controlled Nitrogen-Doped Mesoporous Carbon Nanosphere Supported Ultrafine Ru Nanoparticles for Selective Hydrogenation of Quinolines.

Nitrogen-doped mesoporous carbon nanosphere (NMCS) with tunable sizes and uniform mesoporosity was synthesized by a facile soft-templating method. During the synthesis, F127 (PEO-PPO-PEO triblock copolymer) could be used not only as a soft template to generate the mesostructure but also as a size-control agent to tailor the size of NMCS in a relatively wide range of 100 to 700 nm. In addition, the synthesis process was simple and suitable for large-scale production. Moreover, the NMCS was used as support of ultrafine Ru nanoparticles (Ru/NMCS), which exhibited good catalytic performances for selective hydrogenation of quinolones. It is expected that the simple synthetic strategy for the NMCS can generate extensive interest in many catalysis and sorption applications.

Nitrogen and Oxygen Co-Doping Assisted Synthesis of Highly Dispersed Pd Nanoparticles on Hollow Carbon Spheres as Efficient Electrocatalysts for Oxygen Reduction Reaction.

Electrochemical reduction of O2 (oxygen reduction reaction; ORR) provides an opportunity to achieve the commercial application of clean energy, but it remains challenging, so the rational design of inexpensive and efficient electrocatalysts is required. Palladium-based electrocatalysts have emerged as a class of the most promising candidates for the ORR, which could accelerate O2 adsorption, dissociation, and electron transfer. However, the metal Pd atoms tend to aggregate into nanoparticles, driven by the tendency of the metal surface free energy to decrease, which significantly reduces the atom utilization efficiency and the catalytic performance. Herein, a facile double solvent impregnation method is developed for the synthesis of highly dispersed Pd nanoparticles supported on hollow carbon spheres (Pd-HCS), which could act as efficient electrocatalysts for the ORR in basic solution. Systematic investigation reveals that the nitrogen-containing and oxygen-containing functional groups (especially -COOH groups) are essential for achieving the homogenous dispersion of Pd nanoparticles. Significantly, the optimized Pd-HCS electrocatalyst with homogeneously dispersed Pd nanoparticles and Pd-N sites delivers high electrocatalytic activity for the ORR and excellent stability, without significant decay in onset potential and half-potential and good resistance to methanol crossover. This work offers a new route for the rational design of efficient ORR electrocatalysts toward advanced materials and emerging applications.

Fe/Fe3 C Nanoparticles Encapsulated in N-Doped Hollow Carbon Spheres as Efficient Electrocatalysts for the Oxygen Reduction Reaction over a Wide pH Range.

Nonprecious-metal-based electrocatalysts with low cost, high activity, and stability are considered as one of the most promising alternatives to Pt-based catalysts for the oxygen reduction reaction (ORR). Herein, an economical and easy-to-fabricate catalyst is developed, that is, Fe/Fe3 C embedded in N-doped hollow carbon spheres (Fe/Fe3 C/NHCS), which gave the half-wave potential of 0.84 V in 0.1 m KOH, similar to the commercial Pt/C catalyst. Surprisingly, the favorable ORR performance of the as-prepared catalyst was obtained in both acidic and neutral conditions with almost a four-electron pathway and low H2 O2 yield, which desirable the development of the proton exchange membrane (PEM) and microbial electrolysis cell (MEC) technology. Additionally, the obtained catalyst demonstrated better long-term stability and high methanol tolerance over a wide range of pH. These features could be mainly attributed to the synergistic effect between Fe/Fe3 C and Fe-Nx sites, the hollow structure with mesopores, and the well-dispersed Fe/Fe3 C nanoparticles owing to the existence of the abundant hydrophilic groups within the HCS precursor. As such, designing an efficient and cheap ORR catalyst that can operate at alkaline, acidic, and neutral solutions is highly desirable, yet challenging.

Analysis of volatile components in Dalbergia cochinchinensis Pierre by a comprehensive two-dimensional gas chromatography with mass spectrometry method using a solid-state modulator.

Volatile components in Dalbergia cochinchinensis Pierre were analysed using a comprehensive two-dimensional gas chromatography with mass spectrometry method featuring a new solid-state modulator. Compared to one-dimensional gas chromatography, the number of detected peaks were significantly increased. A total of 45 major compounds were identified in this study and the forward and reverse match factors of these compounds were both above 800. The results showed that the volatile components in Dalbergia cochinchinensis Pierre were primarily aldehyde and ketone compounds such as benzaldehyde, cinnamaldehyde, 4-chromanone, 1-(2-hydroxyphenyl)ethanone and acetophenone. In addition, a semi-quantitative analysis was conducted to determine the contents of the detected compounds based on peak area percentage. Moreover, the repeatability of the comprehensive two-dimensional gas chromatography-mass spectrometry analysis in this study was quite satisfactory with relative standard deviations less than 12.7% for intraday and 17.3% for interday measurements.

Synthesis and biological evaluation of isoxazoline derivatives as potent M1 muscarinic acetylcholine receptor agonists.

A series of azacyclic compounds substituted with isoxazole and 5-substituted isoxazolines were synthesized as acyclic modifications of the oxime class M1 mACh receptor agonist. Among them, 3-(tetrahydropyrin-3-yl)-5-(2-pyrrolodin-1-yl)isoxazoline compound 4f displayed potent and selective M1 mACh receptor agonist activity in the functional calcium mobilization assay (EC50=31 nM). Introduction of 2-pyrrolidinone and 3-tetrahydropyridine groups are pivotal to the high potency. Moreover, 4f was found to facilitate non-amyloidogenic amyloid precursor protein (APP) processing by significantly increasing ERK1/2 phosphorylation and sAPPα secretion, known disease-modifying effects related to M1 mAChR agonists in Alzheimer's disease (AD).

Study on the flow mechanism and frequency characteristics of rales in lower respiratory tract.

The frequency characteristics of lung sounds have great significance for noninvasive diagnosis of respiratory diseases. The rales in the lower respiratory tract region that can provide rich information about symptoms of respiratory diseases are not clear. In this paper, a three-dimensional idealized bifurcated lower respiratory tract geometric model, which contains 3rd to 13th generation (G3-G13) bronchi is constructed, where Re ∼ 10 1 - 10 3 , and then the large eddy simulation and volume of fluid are used to study the fluid flow characteristics. Ffowcs Williams and Hawkings model are subsequently used to study the frequency characteristics of rale of different generations of bronchi. The results showed that bronchial blockage and sputum movement will enhance the turbulence intensity and vortex shedding intensity of flow. The dominant frequency and highest value of sound pressure level (SPL) of rhonchi/moist crackles decrease with the increase of bronchial generation. The change rates of dominant frequency of rhonchi / moist crackles in adjacent generations were 5.0 ± 0.1 ~ 9.1 ± 0.2% and 3.1 ± 0.1 ~ 11.9 ± 0.3%, respectively, which is concentrated in 290 ~ 420 Hz and 200 ~ 300 Hz, respectively. The change rates of SPL of rhonchi/moist crackles were 8.8 ± 0.1 ~ 15.7 ± 0.1% and 7.1 ± 0.1 ~ 19.5 ± 0.2%, respectively, which is concentrated in 28 ~ 50 dB and 16 ~ 32 dB, respectively. In the same generation of bronchus (e.g., G8, G9) with the same degree of initial blockage, the dominant frequency and SPL of moist crackles can be 3.7 ± 0.2% and 4.5 ± 0.3% slightly higher than that of rhonchi, respectively. This research is conducive to the establishment of a rapid and accurate noninvasive diagnosis system for respiratory diseases.

Design of heterostructured hydrangea-like FeS2/MoS2 encapsulated in nitrogen-doped carbon as high-performance anode for potassium-ion capacitors.

The means of structural hybridization such as heterojunction construction and carbon-coating engineering for facilitating charge transfer and electron transport are considered viable strategies to address the challenges associated with the low rate capability and poor cycling stability of sulfide-based anodes in potassium-ion batteries (PIBs). Motivated by these concepts, we have successfully prepared a hydrangea-like bimetallic sulfide heterostructure encapsulated in nitrogen-doped carbon (FMS@NC) using a simple solvothermal method, followed by poly-dopamine wrapping and a one-step sulfidation/carbonization process. When served as an anode for PIBs, this FMS@NC demonstrates a high specific capacity (585 mAh g-1 at 0.05 A/g) and long cycling stability. Synergetic effects of mitigated volume expansions and enhanced conductivity that are responsbile for such high performance have been verified to originate from the heterostructured sulfides and the N-doped carbon matrix. Meanwhile, comprehensive characterization reveals existence of an intercalation-conversion hybrid K-ion storage mechanism in this material. Impressively, a K-ion capacitor with the FMS@NC anode and a commercial activated carbon cathode exhibits a superior energy density of up to 192 Wh kg-1, a high power density, and outstanding cycling stability. This study provides constructive guidance for designing high-performance and durable potassium-ion storage anodes for next-generation energy storage devices.

Superexchange-stabilized long-distance Cu sites in rock-salt-ordered double perovskite oxides for CO2 electromethanation.

Cu-oxide-based catalysts are promising for CO2 electroreduction (CO2RR) to CH4, but suffer from inevitable reduction (to metallic Cu) and uncontrollable structural collapse. Here we report Cu-based rock-salt-ordered double perovskite oxides with superexchange-stabilized long-distance Cu sites for efficient and stable CO2-to-CH4 conversion. For the proof-of-concept catalyst of Sr2CuWO6, its corner-linked CuO6 and WO6 octahedral motifs alternate in all three crystallographic dimensions, creating sufficiently long Cu-Cu distances (at least 5.4 Å) and introducing marked superexchange interaction mainly manifested by O-anion-mediated electron transfer (from Cu to W sites). In CO2RR, the Sr2CuWO6 exhibits significant improvements (up to 14.1 folds) in activity and selectivity for CH4, together with well boosted stability, relative to a physical-mixture counterpart of CuO/WO3. Moreover, the Sr2CuWO6 is the most effective Cu-based-perovskite catalyst for CO2 methanation, achieving a remarkable selectivity of 73.1% at 400 mA cm-2 for CH4. Our experiments and theoretical calculations highlight the long Cu-Cu distances promoting *CO hydrogenation and the superexchange interaction stabilizing Cu sites as responsible for the superb performance.

In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers.

The growth inhibition of human cancer cells via T-type Ca(2+) channel blockade has been well known. Herein, a series of new 3,4-dihydroquinazoline derivatives were synthesized via a brief SAR study on KYS05090 template and evaluated for both T-type Ca(2+) channel (Cav3.1) blockade and cytotoxicity on three human ovarian cancer cells (SK-OV-3, A2780 and A2780-T). Most of compounds except 6i generally exhibited more potent cytotoxicity on SK-OV-3 than mibefradil as a positive control regardless of the degree of T-type channel blockade. In particular, eight compounds (KYS05090, 6a and 6c-6h) showing strong channel blockade exhibited almost equal and more potent cytotoxicity on A2780 when compared to mibefradil. On A2780-T paclitaxel-resistant human ovarian carcinoma, two compounds (KYS05090 and 6d) were 20-fold more active than mibefradil. With respect to cell cycle arrest effect on A2780 and A2780-T cells, KYS05090 induced large proportion of sub-G1 phase in the cell cycle progression of A2780 and A2780-T, meaning the induction of cancer cell death instead of cell cycle arrest via blocking T-type Ca(2+) channel. Among new analogues, compounds 6g and 6h induced cell cycle arrest at G1 phase of A2780 and A2780-T cells in dose-dependent manner and exhibited strong anti-proliferation effects of ovarian cancer cells by blocking T-type Ca(2+) channel. Furthermore, 6g and 6h possessing strong cytotoxic effects could induce apoptosis of A2780 cells, which was detected by confocal micrographs using DAPI staining.

Theoretical design and experimental implementation of Ag/Au electrodes for the electrochemical reduction of nitrate.

The current imbalance in the biogeochemical cycle of nitrogen is as serious as that of carbon. One way to mitigate this problem is through the electrochemical reduction of nitrates under mild conditions, which is an appealing though not fully understood process. Therefore, deeper insight into the electrocatalytic reaction mechanism is needed to optimize this process. Here we thoroughly analyse the adsorption energy of nitrate with DFT calculations on various surface facets of pure Au, Ag, and their near-surface and surface alloys, as the adsorption and subsequent reduction of nitrate are thought to be rate limiting in the electrocatalytic reaction. The observed systematic trends allow prediction of the surface with highest electrocatalytic activity for the reduction of nitrate. This prediction was verified experimentally by depositing sub-monolayer amounts of Ag on polycrystalline Au electrodes. We observe a well-defined volcano curve which correlates the amount of Ag deposited on the surface with the current density at a fixed potential, with the peak activity around 2/3 ML Ag surface coverage. The electrocatalytic activity and stability of the bimetallic Ag-Au systems, found through the interplay of theoretical modelling and empirical observations, serve as a clear example for the rational design of novel catalytic materials and confirm the key role that the adsorption of nitrate plays in the overall nitrate reduction rate.

Effects of Duhuojisheng Tang and combined therapies on prolapse of lumbar intervertebral disc: a systematic review of randomized control trails.

OBJECTIVE: A systematic review of the literature was conducted to evaluate the curative effect and safety of Duhuojisheng Tang on prolapse of the lumbar intervertebral disc. METHODS: The databases of PubMed, China National Knowledge Infrastructure (CNKI), Chinese Scientific Journals Database (VIP), Chinese Biomedical Literature Database (CBM) and Chinese Medical Citation Index (CMCI) were searched up to January 30, 2012. Randomized controlled trials were selected to compare Duhuojisheng Tang with one or more of the following treatments: traction, acupuncture, massage, cupping and Western medical treatment. The quality-evaluating standard and the software RevMan 5.1 in Cochrane coordinative net were used to analyze the data. The effective indexes of the results were clinical curative rate, effectiveness of alleviating clinical symptoms and adverse reaction. RESULTS: Thirty-one randomized controlled trials of low quality, involving 3915 patients were systematically evaluated. Statistical analyses showed that good curative effect was achieved in both the group using Duhuojisheng Tang alone and with combined therapies. CONCLUSION: Using Duhuojisheng Tang alone or combined with other therapies can effectively improve pain, leg-raising height and other clinical symptoms of patients with prolapse of lumbar intervertebral disc. Due to low methodological quality of the articles, no exact recommendations can be made.