1.
Org Lett
; 17(18): 4608-11, 2015 Sep 18.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26335386
RESUMO
An organocatalytic asymmetric Mannich reaction of allylic ketones with cyclic N-sulfonyl α-iminoester has been developed. By using a saccharide-derived chiral tertiary amino-thiourea catalyst, a range of allylic ketones and N-sulfonyl ketimines reacted smoothly to afford tetrasubstituted α-amino esters in high yields with good to excellent regio-, diastero-, and enantioselectivities.