Detalhe da pesquisa
1.
Discovery of 1'-(1-phenylcyclopropane-carbonyl)-3H-spiro[isobenzofuran-1,3'-pyrrolidin]-3-one as a novel steroid mimetic scaffold for the potent and tissue-specific inhibition of 11ß-HSD1 using a scaffold-hopping approach.
Bioorg Med Chem Lett
; 69: 128782, 2022 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35537608
2.
Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase δ Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy.
J Pharmacol Exp Ther
; 374(1): 211-222, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32345620
3.
INCB040093 Is a Novel PI3Kδ Inhibitor for the Treatment of B Cell Lymphoid Malignancies.
J Pharmacol Exp Ther
; 364(1): 120-130, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29127109
4.
The effect of long-term ruxolitinib treatment on JAK2p.V617F allele burden in patients with myelofibrosis.
Blood
; 126(13): 1551-4, 2015 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26228487
5.
Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor.
Cancer Discov
; 12(6): 1482-1499, 2022 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35254416
6.
Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor.
J Med Chem
; 64(15): 10666-10679, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34269576
7.
A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade.
Nat Commun
; 12(1): 4445, 2021 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34290245
8.
INCB054828 (pemigatinib), a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays activity against genetically defined tumor models.
PLoS One
; 15(4): e0231877, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32315352
9.
CCR2 modulates inflammatory and metabolic effects of high-fat feeding.
J Clin Invest
; 116(1): 115-24, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16341265
10.
The Novel Bromodomain and Extraterminal Domain Inhibitor INCB054329 Induces Vulnerabilities in Myeloma Cells That Inform Rational Combination Strategies.
Clin Cancer Res
; 25(1): 300-311, 2019 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30206163
11.
Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies.
PLoS One
; 13(6): e0199108, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29927999
12.
Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells.
Cancer Biol Ther
; 5(6): 657-64, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16627989
13.
Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics.
J Med Chem
; 48(21): 6544-8, 2005 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16220970
14.
Dexamethasone and tumor necrosis factor-alpha act together to induce the cellular inhibitor of apoptosis-2 gene and prevent apoptosis in a variety of cell types.
Endocrinology
; 143(10): 3866-74, 2002 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-12239098
15.
Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters.
Gene
; 290(1-2): 35-43, 2002 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12062799
16.
Induction of endogenous genes by peroxisome proliferator activated receptor alpha ligands in a human kidney cell line and in vivo.
J Steroid Biochem Mol Biol
; 85(1): 71-9, 2003 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-12798359
17.
Validation of standards for quantitative assessment of JAK2 c.1849G>T (p.V617F) allele burden analysis in clinical samples.
Genet Test Mol Biomarkers
; 17(5): 429-37, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23537216
18.
The 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy.
Diabetes Care
; 33(7): 1516-22, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20413513
19.
Current themes in microarray experimental design and analysis.
Drug Discov Today
; 7(5): 290-2, 2002 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-11854051
20.
Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist, INCB3344.
J Immunol
; 175(8): 5370-8, 2005 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16210643