Detalhe da pesquisa
1.
Discovery of dehydro-oxopiperazine acetamides as novel bradykinin B1 receptor antagonists with enhanced in vitro potency.
Bioorg Med Chem Lett
; 22(2): 1061-7, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22197141
2.
Design and synthesis of novel amide AKT1 inhibitors with selectivity over CDK2.
Bioorg Med Chem Lett
; 21(18): 5191-6, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21824779
3.
Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11ß-HSD1 inhibitors.
Bioorg Med Chem Lett
; 21(1): 405-10, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21093258
4.
3-Oxo-2-piperazinyl acetamides as potent bradykinin B1 receptor antagonists for the treatment of pain and inflammation.
Bioorg Med Chem Lett
; 21(11): 3384-9, 2011 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21514825
5.
Discovery of amide replacements that improve activity and metabolic stability of a bis-amide smoothened antagonist hit.
Bioorg Med Chem Lett
; 21(18): 5206-9, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21840217
6.
Aryl sulfonamides containing tetralin allylic amines as potent and selective bradykinin B1 receptor antagonists.
Bioorg Med Chem Lett
; 20(15): 4593-7, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20573508
7.
Design of 1-piperazinyl-4-arylphthalazines as potent Smoothened antagonists.
Bioorg Med Chem Lett
; 20(12): 3618-22, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20493695
8.
Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines.
Bioorg Med Chem Lett
; 20(15): 4607-10, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20594845
9.
2-Aminothiadiazole inhibitors of AKT1 as potential cancer therapeutics.
Bioorg Med Chem Lett
; 20(5): 1652-6, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20137932
10.
Azole-based inhibitors of AKT/PKB for the treatment of cancer.
Bioorg Med Chem Lett
; 20(5): 1559-64, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20137943
11.
Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity.
J Comb Chem
; 12(5): 676-86, 2010 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-20666436
12.
Stereoselective synthesis of anti-N-protected 3-amino-1,2-epoxides by nucleophilic addition to N-tert-butanesulfinyl imine of a glyceraldehyde synthon.
J Org Chem
; 74(16): 5975-82, 2009 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-19586010
13.
Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors.
Bioorg Med Chem Lett
; 19(6): 1797-801, 2009 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19217779
14.
Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11 beta-HSD1 inhibitors.
Bioorg Med Chem Lett
; 19(5): 1446-50, 2009 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19185488
15.
Discovery of aryl aminoquinazoline pyridones as potent, selective, and orally efficacious inhibitors of receptor tyrosine kinase c-Kit.
J Med Chem
; 51(11): 3065-8, 2008 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18447379
16.
Discovery of dihydroquinoxalinone acetamides containing bicyclic amines as potent Bradykinin B1 receptor antagonists.
Bioorg Med Chem Lett
; 18(16): 4477-81, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18674903
17.
Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents.
Bioorg Med Chem Lett
; 18(3): 1037-41, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18178086
18.
Discovery of amido-benzisoxazoles as potent c-Kit inhibitors.
Bioorg Med Chem Lett
; 18(18): 5115-7, 2008 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18723346
19.
Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1alpha prolyl hydroxylase-2 inhibitors.
Bioorg Med Chem Lett
; 18(18): 5023-6, 2008 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18755588
20.
Discovery of a potent and selective c-Kit inhibitor for the treatment of inflammatory diseases.
Bioorg Med Chem Lett
; 18(14): 4137-41, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18554909