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1.
Can Fam Physician ; 69(11): 757-761, 2023 11.
Artigo em Inglês | MEDLINE | ID: mdl-37963787

RESUMO

OBJECTIVE: To provide family physicians and general otolaryngologists with a practical, evidence-based, and comprehensive approach to the management of patients presenting with suspected referred otalgia. SOURCES OF INFORMATION: The approach described is a review based on the authors' clinical practices along with research and clinical review articles published between 2000 and 2020. MEDLINE and PubMed were searched using the terms otalgia, referred otalgia, and secondary otalgia. Current guidelines for the management of referred otalgia were also reviewed. MAIN MESSAGE: Otalgia is defined as pain localized to the ear. It is one of the most common head and neck presentations in primary care, otolaryngology, and emergency medicine. Secondary otalgia arises from nonotologic pathology and represents nearly 50% of otalgia cases. Otalgia in the absence of other otologic symptoms is highly indicative of a secondary cause. A thorough assessment of patients presenting with referred otalgia requires an understanding of the possible causes of this condition, including dental and oral mucosal pathologies, temporomandibular joint disorders, cervical spine pathology, sinusitis, upper airway infection, and reflux, as well as head and neck malignancy. This paper aims to highlight the most common causes of referred otalgia, their presentations, and initial options for assessment and management. CONCLUSION: The prevalence of referred otalgia makes this an important condition for family physicians to be able to assess, manage, and triage based on patient presentation and examination. Understanding the common causes of referred otalgia will help reduce wait times for specialist assessment and allow ease and speed of access to management options for patients in community clinics.


Assuntos
Sinusite , Transtornos da Articulação Temporomandibular , Humanos , Dor de Orelha/diagnóstico , Dor de Orelha/etiologia , Dor de Orelha/terapia , Orelha , Transtornos da Articulação Temporomandibular/complicações , Pescoço
2.
J Craniofac Surg ; 33(3): 962-968, 2022 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-34510065

RESUMO

ABSTRACT: Decellularized allogeneic bone chips act as scaffolds for bone tissue regeneration. Owing to their lack of osteogenic potentials compared to autologous bone graft, decellularized bone scaffolds (DBSs) have applied only to small partial bone defects in clinical settings. Furthermore, only decellularized cancellous bone chips have been limitedly used for the purpose of bone regeneration. The cortical bone has less porosity and less osteogenic materials such as bone morphogenetic proteins in comparison with cancellous bone. In this study, we tried to accelerate new bone formation within the decellularized cortical bone scaffold using a vascular pedicle as an in vivo bioreactor.Forty DBSs were divided into 4 groups with different conditionings (DBS+ demineralized bone matrix [DBM], DBS+DBM+me+mesenchymal stem cells, DBS+DBM+vascular pedicle, and DBS+DBM+vascular pedicle+mesenchymal stem cells) and implanted into the back of 5 rabbits. Half of the DBSs were examined at 8 weeks and the other half at 16 weeks to determine vascularization level and osteogenesis within each group. New bone formation and bone-forming cells related to osteogenesis were observed via histological staining. Inclusion of the vascular pedicle resulted in larger areas of bone regeneration. With time, osteon structures became more prominent in groups containing the vascular pedicle.In summary, vascularized DBSs combined with a vascular pedicle have shown promising results for bone regeneration, thereby representing potential therapeutic alternatives for autologous bone grafts or bone tissue free transfer in large or segmental bone defects. In addition, demineralized whole cortical bone matrix along with vascular pedicle and various bone inductive materials, such as DBM and recombinant human bone morphogenetic protein-2, may be an additional new option of an ideal osteoinductive system.


Assuntos
Implantes Dentários , Osteogênese , Animais , Matriz Óssea/metabolismo , Osso Cortical , Ósteon , Humanos , Coelhos , Alicerces Teciduais/química
3.
Aesthetic Plast Surg ; 46(3): 1042-1049, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-34845513

RESUMO

BACKGROUND: Since the issue of breast implant-associated anaplastic large cell lymphoma, smooth breast implants tend to be the more preferred option in implant-based breast reconstructions, compared to its use previously. The most unfavorable aspect of smooth implants is lateral and inferior displacements, which are more common in patients who undergo breast reconstruction compared to augmentation mammoplasty. Hence, we introduce a prevention method for implant displacement using an acellular dermal matrix garter belt. METHODS: This study is a retrospective review of patients who had undergone implant-based breast reconstruction between April 2019 and December 2020. Some patients who have highly possibility of implant displacement, had undergone the application of an ADM garter belt to prevent lateral or superior displacement. Implant displacement was assessed before and at least 6 months postoperatively. RESULTS: A total of 155 IBR cases were recorded. ADM garter belts were applied in 27 patients (17.4%) who had a high tendency of implant displacement for several reasons, which could be classified into two categories: wide breast pocket (56%) and tight inferomedial breast pocket (44%). The intraoperative average distance of lateral slipping on patients' reconstructed breasts from the chest wall midline in supine position was 3.02 ± 0.81 cm and corrected to1.54 ± 0.69 cm at least 6 months postoperative follow-up. CONCLUSIONS: We utilized an ADM strap as an internalized garter belt to minimize implant displacement. This ADM garter belt combined with capsuloplasty might be an effective way to prevent the displacement of smooth implants in the patients with a greater risk of implant displacement. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors   www.springer.com/00266.


Assuntos
Derme Acelular , Implante Mamário , Implantes de Mama , Neoplasias da Mama , Mamoplastia , Implante Mamário/efeitos adversos , Implante Mamário/métodos , Implantes de Mama/efeitos adversos , Neoplasias da Mama/etiologia , Estudos de Coortes , Estética , Feminino , Humanos , Mamoplastia/métodos , Estudos Retrospectivos , Resultado do Tratamento
4.
Aesthetic Plast Surg ; 46(1): 152-160, 2022 02.
Artigo em Inglês | MEDLINE | ID: mdl-34269845

RESUMO

BACKGROUND: Various operative methods exist for nipple reconstruction. Selection of an appropriate skin flap and core strut material is imperative in achieving a satisfactory outcome in nipple reconstruction. Long-term maintenance of nipple projection requires further investigation by surgeons. We propose a new technique that uses a semilunar flap and omega-shaped acellular dermal matrix (ADM). METHODS: Total 53 nipples were reconstructed by this method. An omega-shaped ADM strut was inserted into the barrel made by a semilunar flap. The footplates of omega-shaped ADM struts were spread out under the subcutaneous tissue of the donor site of the semilunar flap to support the dome of the omega strut. RESULTS: The mean maintenance rate of nipple projection was 95.12 ± 6.30% at 3 weeks, 80.60 ± 8.93% at 3 months, and 71.70 ± 8.67% at 6 months postoperatively when compared to the projection observed in the immediate postoperative period. Thirty-five patients (66.0%) showed a maintenance rate over 70% at 6 months post operation, with most patients (94.3%) demonstrating a maintenance rate greater than 60%. CONCLUSIONS: Our study with the omega-shaped ADM strut showed superior maintenance rates of projection when compared to other studies on that used AlloDerm® as a core strut for nipple reconstruction. Omega-shaped struts, when made with cross-linked thick ADM, supported the skin flap quite well. We propose that our method combining the semilunar flap with an omega-shaped ADM may be a good option for nipple reconstruction. LEVEL OF EVIDENCE IV: "This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors   www.springer.com/00266 ."


Assuntos
Derme Acelular , Neoplasias da Mama , Mamoplastia , Neoplasias da Mama/cirurgia , Feminino , Humanos , Mamoplastia/métodos , Mastectomia/métodos , Mamilos/cirurgia , Estudos Retrospectivos , Resultado do Tratamento
5.
J Craniofac Surg ; 31(3): 618-621, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31842084

RESUMO

BACKGROUND: Fat grafting has been widely used for facial rejuvenation and soft tissue reconstruction. However, it is associated with a lower retention rate than expected and complications such as fat necrosis or calcification. Several techniques that may increase the survival rate of fat grafts have been proposed. The techniques that promote the recipient sites vascularity to increase the survival rate of fat grafts include administration of growth factors, platelet- rich plasma, and adipose derived-stem cells or preconditioning of the recipient fat graft site. METHODS: In this study, the authors evaluated the effect of hyaluronidase on autologous fat graft survival by pretreatment with hyaluronidase at the recipient site by using an animal model. In the experimental group, the recipient site of the fat graft was pretreated with hyaluronidase before fat grafting, whereas the control group was pretreated with normal saline. RESULTS: After 8 weeks of fat grafting, the average volume retention was 78.2% in the experimental group and 68.6% in control group. Considerable fibrosis between the fat globules in the control group was confirmed with Masson trichrome staining. CD31 immunofluorescence staining was performed and stained vessels were counted. Counted vessel number was significantly greater in the experimental group than in the control group. CONCLUSIONS: Pretreatment of hyaluronidase on the fat graft recipient site is a good option to enhance the outcome of the fat graft in the clinical setting.


Assuntos
Tecido Adiposo/transplante , Hialuronoglucosaminidase/metabolismo , Adipócitos , Animais , Modelos Animais de Doenças , Sobrevivência de Enxerto , Camundongos , Transplante Autólogo
6.
Clin Anat ; 32(4): 471-475, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30421817

RESUMO

There are various modifications of the transverse rectus abdominis musculocutaneous flap and deep inferior epigastric perforator flap to reduce the morbidity of the donor site or to augment the vascularity of the flap. For microanastomosis of multiple pedicles, multiple recipient vessels or an intervening vein graft should be provided. In addition, alternative perforator-based flaps used in breast reconstruction have small caliber pedicles. Therefore, small recipient vessels such as internal thoracic artery perforators are more suitable for appropriate microanastomosis. Therefore, it is important to acquaint the distribution and anatomical characteristics of internal thoracic artery perforators. We researched the perforators running in the intercostal spaces under the pectoralis major muscle to provide an overview of the anatomical distribution and characteristics of the perforators in patients who underwent immediate subpectoral implant-based breast reconstructions. In our study, the major perforators (diameter > 1.5 mm) were easily found 2-7 cm medially between the third and fourth intercostal space and were sparse in the lateral area from the midline of the breast (usually 8-9 cm lateral to the midsternal line) and above the third rib. In each side of the breast, the average number of perforators greater than 1.5 mm was 1.6, and the average number of perforators between 1 mm and 1.5 mm in diameter was 3.2. Our results provide information about perforators in the anterior chest wall related to the breast area. Clin. Anat. 32:471-475, 2019. © 2018 Wiley Periodicals, Inc.


Assuntos
Artéria Torácica Interna/anatomia & histologia , Retalho Perfurante/irrigação sanguínea , Feminino , Humanos
7.
Can Fam Physician ; 69(11): 762-766, 2023 11.
Artigo em Francês | MEDLINE | ID: mdl-37963797

RESUMO

OBJECTIF: Présenter aux médecins de famille et aux otorhinolaryngologistes généraux une approche pratique, exhaustive et fondée sur des données probantes pour la prise en charge des patients chez qui l'on soupçonnne une otalgie référée. SOURCES DE L'INFORMATION: L'approche décrite est une revue qui se fonde sur les pratiques cliniques des auteurs, et sur des articles de recherche et des revues cliniques publiés entre 2000 et 2020. Une recension a été effectuée dans MEDLINE et PubMed à l'aide des expressions en anglais otalgia, referred otalgia et secondary otalgia. Les lignes directrices actuelles sur la prise en charge de l'otalgie référée ont aussi été passées en revue. MESSAGE PRINCIPAL: L'otalgie désigne une douleur localisée à l'oreille. Il s'agit de l'une des présentations liées à la tête et au cou les plus fréquentes en soins primaires, en otorhinolaryngologie et en médecine d'urgence. L'otalgie secondaire découle d'une pathologie non otologique, et près de 50 % des cas d'otalgie lui sont attribuables. L'otalgie sans autres symptômes otologiques évoque fortement une cause secondaire. Une évaluation rigoureuse des patients qui présentent une otalgie référée nécessite une bonne compréhension des causes possibles de ce problème, notamment des pathologies dentaires et des muqueuses buccales, des troubles de l'articulation temporo-mandibulaire, des pathologies de la colonne cervicale, de la sinusite, des infections des voies aériennes supérieures et du reflux, de même que des cancers de la tête et du cou. Cet article a pour but de mettre en évidence les causes les plus fréquentes d'une otalgie référée, leurs caractéristiques, et les options initiales pour l'évaluation et la prise en charge. CONCLUSION: La prévalence de l'otalgie référée fait en sorte qu'il importe que les médecins de famille soient en mesure d'évaluer, de prendre en charge et de trier les patients d'après la présentation et l'examen. Une bonne compréhension des causes courantes de l'otalgie référée aide à réduire le temps d'attente avant une évaluation spécialisée, et permet de faciliter et d'accélérer l'accès par les patients à des options de prise en charge dans les cliniques communautaires.

8.
J Craniofac Surg ; 28(3): 838-841, 2017 May.
Artigo em Inglês | MEDLINE | ID: mdl-28085765

RESUMO

The hyaluronic acid-based filler (HA filler) is used worldwide in various applications. In particular, the HA filler is used in the plastics and cosmetic medical field for facial rejuvenation and contouring. In this setting, it is injected into the skin or underlying tissue. Complications of HA filler injection have been relieved using hyaluronidase. However, there is no standard dose to adjust for undesirable HA filler lumpness. In this study, the authors tried to analyze any quantitative correlation between HA filler and hyaluronidase. The back of each rat (total 14 rats) was divided into 4 sites. A volume of 0.5 mL HA filler was injected into the subdermal layer at each site and HA filler nodules were created on the dorsum of each rat. Each nodule was allocated to groups 1, 2, 3, and 4 according to the different concentrations of hyaluronidase. As a result, the injected HA filler volume doubled within 4 days of injection, and then decreased slowly thereafter in group 1 (control group with normal saline only). A 30 unit hyaluronidase treatment compensated for the initial volume increase (approximately 30%) with HA filler (0.5 ml) at the fourth day. Sixty units of hyaluronidase reduced the initial volume (0.5 mL) of overinjected or misplaced HA filler on the fourth day. Approximately 90 units of hyaluronidase can reduce to the volume by 0.25 mL (50%) of the injected HA filler on the fourth day. The authors believe that this quantitative analysis of hyaluronidase concentration is helpful to plan the amount of hyaluronidase for correction of HA filler injection errors.


Assuntos
Procedimentos Cirúrgicos Dermatológicos , Ácido Hialurônico , Hialuronoglucosaminidase , Animais , Preenchedores Dérmicos/administração & dosagem , Preenchedores Dérmicos/efeitos adversos , Procedimentos Cirúrgicos Dermatológicos/efeitos adversos , Procedimentos Cirúrgicos Dermatológicos/instrumentação , Procedimentos Cirúrgicos Dermatológicos/métodos , Cálculos da Dosagem de Medicamento , Ácido Hialurônico/administração & dosagem , Ácido Hialurônico/efeitos adversos , Hialuronoglucosaminidase/administração & dosagem , Hialuronoglucosaminidase/efeitos adversos , Injeções Subcutâneas , Ratos , Resultado do Tratamento , Viscossuplementos/administração & dosagem , Viscossuplementos/efeitos adversos
9.
J Craniofac Surg ; 28(8): 2038-2041, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28938317

RESUMO

The treatment has been improved on the accurate reduction of blow-out fracture for many decades. But still, it has been limited to reduce completely when surgeons are approaching by conventional technique. The authors analyzed the postoperative results using computed tomography (CT) scans after conventional open reduction of isolated medial wall fracture. Thirty-seven patients with isolated medial wall fracture were reviewed. All patients underwent preoperative, immediate, and postoperative CT scans. Two surgeons have performed the surgery by conventional open reduction with transcaruncular approach and absorbable mesh insertion. The authors evaluated changing orbital volume and distance, comparing the immediate and 6 months postoperative outcomes with preoperative outcome. The differences between immediate postoperative and 6 months postoperatively data were statistically evaluated. The authors used the distant value to minimize bias of CT view selection. Significant differences from the 2 kinds of data were observed (P < 0.05 for volume, P < 0.01 for distance, Paired t test). Bone remodeling process after conventional open reduction of orbital wall has not been fully understood. Most popular technique is conventional open reduction and mesh insertion but it is not easy for surgeons to reduce fractured bones completely. The authors analyzed the bone remodeling after incomplete reduction. These results suggest that the decreased measurements might be caused from the scar contracture with fibrosis. This research is very limited to explain the change while bone remodeling is progressed. Further research should be continued to discover the understanding of the process.


Assuntos
Órbita/diagnóstico por imagem , Órbita/cirurgia , Fraturas Orbitárias/cirurgia , Adolescente , Adulto , Idoso , Remodelação Óssea , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Redução Aberta , Período Pós-Operatório , Fatores de Tempo , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Adulto Jovem
10.
Ann Plast Surg ; 76(5): 483-4, 2016 May.
Artigo em Inglês | MEDLINE | ID: mdl-25046673

RESUMO

Pixie ear deformity is a condition in which the inferior edge of the helix of the ear is attached to the cheek without a convolutional notch at the ear lobule-cheek junction. Numerous surgical techniques have been proposed to correct pixie earlobe deformities. However, several of these techniques result in anterior or inferior scars of the ear lobules or dog-ear deformities. Such visible scarring detracts from the esthetics of the ear lobule.We report a novel method for the correction of pixie ear deformities in patients with small ear lobules. A hypoplastic ear lobule was expanded by a V-Y advancement flap designed on the posterior aspect of the ear lobule, and a dermofat graft was placed in the subcutaneous layer under the advanced flap. As a result, the pixie ear lobe deformity was camouflaged by the expanded ear lobule. Moreover, no scars appeared on the anterior or inferior sides of the ear lobule, and a natural appearance of the ear lobe was achieved.We conclude that this method is a feasible alternative surgical option for hypoplastic pixie ear lobe deformities to avoid visible scarring in the anterior or inferior aspects of the ear lobe.


Assuntos
Técnicas Cosméticas , Pavilhão Auricular/cirurgia , Retalhos Cirúrgicos , Adulto , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Avaliação de Resultados em Cuidados de Saúde
11.
J Craniofac Surg ; 25(2): 542-3, 2014 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-24577301

RESUMO

Bioabsorbable plate-screw systems are commonly used for the internal fixation of facial bone fractures. The anterior maxilla has a unique curved shape, and fractured bony fragments tend to be small and fragile; therefore, more effective rigid fixation can be achieved using a molded bioabsorbable mesh rather than a bioabsorbable plate. Herein, we describe 2 patients with cheek drooping after a rigid fixation of comminuted maxillary fracture using bioabsorbable meshes and screws.The postoperative courses were uneventful, but both showed soft tissue bulging in the cheek area of the operation site for 12 to 13 months after the operation. No other symptom or sign related to inflammation or foreign body reaction was noted.In comminuted maxillary fractures, bone fragments are more conveniently fixed with a 1-piece molded bioabsorbable mesh. However, it is believed that a single large mesh may interfere with adhesion between the maxillary surface and the overlying soft tissue. Therefore, we recommend using the least amount of mesh to fixate maxillary bone fragments.


Assuntos
Placas Ósseas , Bochecha , Assimetria Facial/etiologia , Fixação Interna de Fraturas/métodos , Fraturas Maxilares/cirurgia , Complicações Pós-Operatórias/etiologia , Fraturas Zigomáticas/cirurgia , Implantes Absorvíveis , Adulto , Criança , Feminino , Humanos , Inflamação/complicações , Masculino
12.
J Hand Surg Am ; 38(7): 1307-14, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-23707593

RESUMO

PURPOSE: To report our technique and results with treating fingertip amputations with flaps and simultaneous nailbed grafts. METHODS: We reconstructed 20 fingertip amputations with loss of bone and nail with flaps combined with nailbed grafts. We reconstructed the volar side of the fingertip with a flap, and the dorsal side of the fingertip with a nailbed grafted to the raw inner surface of the flap. We employed volar V-Y advancement flaps for transverse or dorsal oblique fingertip injuries and generally used abdominal flaps for volar oblique fingertip injuries. We harvested nailbeds from the amputated finger or from the patient's first toe. RESULTS: The length of the amputated fingertips was restored with the flaps, and the lost nailbeds were restored to their natural appearance with the nailbed grafts. We classified the results according to the length of the reconstructed fingertip and the appearance of the nail. Excellent or good results were achieved in 16 cases. Three cases had fair results and 1 had a poor result. We observed favorable results for distal fingertip amputations (Allen type II or III). In particular, most cases that were reconstructed with volar V-Y advancement flaps combined with nailbed grafts demonstrated favorable results. CONCLUSIONS: This method is useful for the restoration of dorsal oblique or transverse type fingertip amputations and is a good alternative when replantation is not an option.


Assuntos
Amputação Traumática/cirurgia , Traumatismos dos Dedos/cirurgia , Unhas/transplante , Procedimentos de Cirurgia Plástica/métodos , Retalhos Cirúrgicos , Adolescente , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento
13.
Artigo em Inglês | MEDLINE | ID: mdl-36901112

RESUMO

To study the effect of rainfall patterns on diatom communities in four major central western streams on the Korean Peninsula during the monsoon seasons of 2013 through 2015, we measured precipitation, environmental factors, and epilithic diatoms at 42 sites before (May) and after (August and September) each monsoon. The Mangyeonggang river and Sapgyocheon stream (SS) had a high percentage of low-permeability soil, and the stream had the highest proportion (49.1%) of surrounding land in urban areas. Precipitation and precipitation frequency was closely correlated with electrical conductivity and nutrients, and this was particularly evident in SS. Epilithic diatom abundance for the most abundant species as, Navicula minima, decreased in the stream in 2013 and 2014 and increased in 2015 when precipitation and precipitation frequency were low. This was not clearly distinguishable in the ecological characteristics of each watercourse's indicator species, except in SS. The dynamic community index was highest in 2015 (ca. 5.50), and the annual changes in the index were clearly shown in SS. The precipitation pattern and the dynamic community index were negatively correlated (r = -0.026~-0.385), and the precipitation within 2 weeks (r = -0.480 for SS) before the second sampling and the frequency of 10 mm of precipitation were closely correlated in the stream (r = -0.450 for SS). The distribution of epilithic diatoms in the four watercourses is therefore affected by monsoon precipitation and precipitation frequency, and the dynamic community index is determined by soil characteristics and land use.


Assuntos
Diatomáceas , Monitoramento Ambiental , Solo , Rios , República da Coreia
14.
Tissue Eng Regen Med ; 19(3): 553-563, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-35312988

RESUMO

BACKGROUND: Autologous fat grafting is one of the most common procedures used in plastic surgery to correct soft tissue deficiency or depression deformity. However, its clinical outcomes are often suboptimal, and lack of metabolic and architectural support at recipient sites affect fat survival leading to complications such as cyst formation, calcification. Extracellular matrix-based scaffolds, such as allograft adipose matrix (AAM) and poly(lactic-co-glycolic) acid (PLGA), have shown exceptional clinical promise as regenerative scaffolds. Magnesium hydroxide (MH), an alkaline ceramic, has attracted attention as a potential additive to improve biocompatibility. We attempted to combine fat graft with regenerative scaffolds and analyzed the changes and viability of injected fat graft in relation to the effects of injectable natural, and synthetic (PLGA/MH microsphere) biomaterials. METHODS: In vitro cell cytotoxicity, angiogenesis of the scaffolds, and wound healing were evaluated using human dermal fibroblast cells. Subcutaneous soft-tissue integration of harvested fat tissue was investigated in vivo in nude mouse with random fat transfer protocol Fat integrity and angiogenesis were identified by qRT-PCR and immunohistochemistry. RESULTS: In vitro cell cytotoxicity was not observed both in AAM and PLGA/MH with human dermal fibroblast. PLGA/MH and AAM showed excellent wound healing effect. In vivo, the AAM and PLGA/MH retained volume compared to that in the only fat group. And the PLGA/MH showed the highest angiogenesis and anti-inflammation. CONCLUSION: In this study, a comparison of the volume retention effect and angiogenic ability between autologous fat grafting, injectable natural, and synthetic biomaterials will provide a reasonable basis for fat grafting.


Assuntos
Hidróxido de Magnésio , Alicerces Teciduais , Tecido Adiposo , Aloenxertos , Animais , Materiais Biocompatíveis , Camundongos , Microesferas
16.
Arch Plast Surg ; 46(6): 550-557, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31775208

RESUMO

BACKGROUND: In recent years, breast implants have been frequently placed in the subcutaneous pocket, in the so-called prepectoral approach. We report our technique of prepectoral implant-based breast reconstruction (IBR), as well as its surgical and aesthetic outcomes, in comparison with subpectoral IBR. We also discuss relevant considerations and pitfalls in prepectoral IBR and suggest an algorithm for the selection of patients for IBR based on our experiences. METHODS: We performed 79 immediate breast reconstructions with a breast implant and an acellular dermal matrix (ADM) sling, of which 47 were subpectoral IBRs and 32 were prepectoral IBRs. Two-stage IBR was performed in 36 cases (20 subpectoral, 16 prepectoral), and direct-to-implant IBR in 43 cases (27 prepectoral, 16 subpectoral). The ADM sling supplemented the inferolateral side of the breast prosthesis in the subpectoral group and covered the entire anterior surface of the breast prosthesis in the prepectoral group. RESULTS: The postoperative pain score was much lower in the prepectoral group than in the subpectoral group (1.78 vs. 7.17). The incidence of seroma was higher in the prepectoral group (31.3% vs. 6.4%). Other postoperative complications, such as surgical site infection, flap necrosis, implant failure, and wound dehiscence, occurred at similar rates in both groups. Animation deformities developed in 8.5% of patients in the subpectoral group and rippling deformities were more common in the prepectoral group (21.9% vs. 12.8%). CONCLUSIONS: The indications for prepectoral IBR include moderately-sized breasts with a thick well-vascularized mastectomy flap and concomitant bilateral breast reconstruction with prophylactic mastectomy.

17.
Artigo em Inglês | MEDLINE | ID: mdl-31357556

RESUMO

In the Korean Peninsula's southern estuaries, the distributive characteristics of epilithic diatoms and the important environmental factors predicting species occurrence were examined. The collection of diatoms and measurements of water quality and land-use were performed every May between 2009 and 2016, with no influence from the Asian monsoon and snow. Throughout the study, 564 diatoms were classified with first and second dominant species of Nitzschia inconspicua and N. perminuta. Based on diatom appearance and standing crops, the 512 sampling stations were divided into four groups by cluster analysis, and two regions, namely the West and East Sea. Geographically, G1, G2, G3, and G4 were located in the East Sea, Southeast Sea, West Sea, and Southwest Sea, respectively. Canonical correspondence analysis (CCA) results indicated that environmental factors, such as turbidity, electric conductivity (EC), and total phosphorus (TP), significantly influenced the distribution of epilithic diatoms. A random forest model showed that major environmental factors influencing the diatom species appearance included EC, salinity, turbidity, and total nitrogen. This study demonstrated that the spatial distribution of epilithic diatoms in the southern estuaries of the Korean Peninsula was determined by several factors, including a geographically higher tidal current-driven turbidity increase and higher industrial or anthropogenic nutrient-loading.


Assuntos
Diatomáceas , Monitoramento Ambiental/métodos , Estuários , Microbiota , Microbiologia da Água , Qualidade da Água , Modelos Teóricos , República da Coreia
18.
Otol Neurotol ; 40(2): e82-e88, 2019 02.
Artigo em Inglês | MEDLINE | ID: mdl-30570612

RESUMO

OBJECTIVE: Assess speech outcomes in unilateral cochlear implant (CI) recipients after addition of a wireless contralateral routing of signals (CROS) microphone. STUDY DESIGN: Prospective cohort study. SETTING: Ambulatory. PATIENTS: Sixteen adult unilateral CI users with nonserviceable hearing on the contralateral side were recruited. Those with AzBio sentence scores of 40 to 80% or Hearing in Noise Test - Quiet (HINT-Q) scores of 60 to 90% with a CI alone were eligible participants. INTERVENTION: Speech testing was carried out with the CROS on and off. MAIN OUTCOME MEASURE: Speech recognition. RESULTS: In the consonant-nucleus-consonant test presented in quiet from the front, word scores were 64.4 (CI) and 63.8% (CI + CROS) (p = 0.72), and phoneme scores were 80.2 (CI) and 80.8% (CI + CROS) (p = 0.65). In AzBio sentence testing in quiet, with the signals projected from the contralateral, front, or ipsilateral to the CI, speech perception with the CI alone was 60.8, 75.9, and 79.1%. With the addition of the CROS microphone, using the same speaker arrangement, speech perception was 69.8 (p < 0.05), 71.8 (p = 0.05), and 71.8 (p < 0.05). In AzBio sentence testing in noise, speech perception with the CI alone was 18.6, 45.3, and 56.3% when signals were projected from contralateral, front, and ipsilateral sides to the CI. The addition of the CROS microphone led to speech perception of 45.3 (p < 0.05), 45.3 (p = 0.86), and 51.4% (p = 0.27) in the same paradigm. CONCLUSIONS: Addition of a wireless CROS microphone to a unilateral CI recipient can improve users' perception of speech in both quiet and noise if speech signals come from the deaf ear, mitigating the head shadow effect.


Assuntos
Implante Coclear , Implantes Cocleares , Audição , Percepção da Fala , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Ruído , Estudos Prospectivos
19.
Plast Reconstr Surg Glob Open ; 6(12): e1947, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30656094

RESUMO

Nipple reconstruction is an essential procedure to change an amorphous breast mound to a distinct breast. Various skin flaps have been proposed for nipple reconstruction. In the C-V flap technique, which is one of the most commonly used flaps for nipple reconstruction, the scar that is developed after closure of the donor site of the V-flap frequently extends beyond a new areola area. To reduce the length of the donor site scar, various modifications of the C-V flap have been proposed. We adopted the semilunar flap instead of the V flap of C-V flap by changing the angle of V flap for nipple reconstruction. The semilunar flap design allowed generation of a donor flap with sufficient width and length of the skin flap for a nipple barrel without increasing the length of the donor site scar. In most cases, the semilunar flaps showed stable outcomes and resulted in angled donor-site scars that were usually located within the boundary of a new areola. We think the semilunar flap represents a good alternative method in nipple reconstruction by changing the angle of the donor-site scar and leaving the scar length within the new areolar area.

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