The development of a long, dual-platform triaxial walkway for the measurement of forces and temporal-spatial data in the clinical assessment of gait.

Force-plate measurement of the ground reaction force (GRF) has, for many years, been considered a vital component of the comprehensive assessment of human gait in the clinical context. For example, the data can be used in the adjustment of prostheses and orthoses and in identifying the mechanisms underlying a gait dysfunction. However, commercial force plates are usually only capable of measuring GRF data from one step in a single traverse. That can lead to problems of 'targeting' and, with less able subjects, fatigue before the necessary data have been collected. Previous work at the University of Surrey resulted in a prototype dual-platform force walkway capable of measuring the vertical component of the GRF and estimating the position of application of that force for multiple foot contacts in a single traverse. In addition, temporal-spatial information, e.g. speed and step length, could also be determined. This paper describes the development of a longer walkway that can measure the three orthogonal components of the GRF and provide and a more accurate estimate of the position of application of that force. Software to allow the rapid reduction of gait data to useful clinical information has also been developed.

Evaluation of the Performance of the THOR-alpha Dummy.

Six European laboratories have evaluated the biomechanical response of the new advanced frontal impact dummy THOR-alpha with respect to the European impact response requirements. The results indicated that for many of the body regions (e.g. shoulder, spine, thorax, femur/knee) the THOR-alpha response was close to the human response. In addition, the durability, repeatability and sensitivity for some dummy regions have been evaluated. Based on the tests performed, it was found that the THOR-alpha is not durable enough. The lack in robustness of the THOR-alpha caused a problem in completing the full test program and in evaluating the repeatability of the dummy. The results have demonstrated that the assessment of frontal impact protection can be greatly improved with a more advanced frontal impact dummy. Regarding biofidelity and injury assessment capabilities, the THOR-alpha is a good candidate however it needs to be brought up to standard in other areas. Based on the results obtained recommendations were defined for the improvement of the THOR-alpha dummy.

5-Alkyltryptamine derivatives as highly selective and potent 5-HT1D receptor agonists.

A series of 5-alkyltryptamines (6) and the corresponding conformationally constrained analogues (8) have been synthesized. The structure activity relationships (SAR) at the 5-position of the indole skeleton and the ethylamine side chain have been studied. Functional activities were assessed using isolated rabbit saphenous vein. Potent, selective ligands were found (6e, Ki 2.5 nM, 5-HT1B/5-HT1D 125-fold) that have potential for treating acute migraine.