Detalhe da pesquisa
1.
Heterocyclic modification of a novel bicyclo[3.1.0]hexane NPY1 receptor antagonist.
Bioorg Med Chem Lett
; 23(13): 3814-7, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23726344
2.
P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.
J Pharmacol Exp Ther
; 326(2): 502-13, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18499745
3.
[3H]BMS-599240--a novel tritiated ligand for the characterization of BACE1 inhibitors.
Eur J Pharmacol
; 593(1-3): 10-5, 2008 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-18655784
4.
Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y(1) receptor antagonist.
Eur J Pharmacol
; 590(1-3): 224-32, 2008 Aug 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-18573246
5.
Synergistic inhibition of Aß production by combinations of γ-secretase modulators.
Eur J Pharmacol
; 812: 104-112, 2017 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28690193
6.
Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780.
Int J Alzheimers Dis
; 2014: 431858, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25097793
7.
Discovery of a Novel Class of Bicyclo[3.1.0]hexanylpiperazines as Noncompetitive Neuropeptide Y Y1 Antagonists.
ACS Med Chem Lett
; 3(3): 222-6, 2012 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900458
8.
Acyl guanidine inhibitors of ß-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis.
J Med Chem
; 55(21): 9208-23, 2012 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23030502
9.
The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression.
J Biol Chem
; 283(34): 22992-3003, 2008 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-18574238
10.
Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology.
J Biol Chem
; 282(51): 36829-36, 2007 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-17932033
11.
Ex vivo occupancy of gamma-secretase inhibitors correlates with brain beta-amyloid peptide reduction in Tg2576 mice.
J Pharmacol Exp Ther
; 323(1): 102-8, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17640949
12.
Synthesis and evaluation of 5,5-diphenylimidazolones as potent human neuropeptide Y5 receptor antagonists.
Bioorg Med Chem
; 14(16): 5517-26, 2006 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16697206
13.
(R)-2-(4-Phenylbutyl)dihydrobenzofuran derivatives as melatoninergic agents.
Bioorg Med Chem Lett
; 15(5): 1345-9, 2005 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15713384
14.
Tetrahydroisoquinoline derivatives as melatonin MT2 receptor antagonists.
Bioorg Med Chem Lett
; 14(23): 5881-4, 2004 Dec 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15501061
15.
Ligand conformation has a definitive effect on 5-HT1A and serotonin reuptake affinity.
Bioorg Med Chem Lett
; 14(17): 4467-70, 2004 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15357973
16.
4-Substituted anilides as selective melatonin MT2 receptor agonists.
Bioorg Med Chem Lett
; 14(4): 1023-6, 2004 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-15013015
17.
Design and synthesis of benzoxazole derivatives as novel melatoninergic ligands.
Bioorg Med Chem Lett
; 14(5): 1197-200, 2004 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-14980664
18.
N-[2-[2-(4-Phenylbutyl)benzofuran-4-yl]cyclopropylmethyl]acetamide: an orally bioavailable melatonin receptor agonist.
Bioorg Med Chem Lett
; 14(20): 5157-60, 2004 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-15380218
19.
Differentially functionalized diamines as novel ligands for the NPY2 receptor.
Bioorg Med Chem Lett
; 13(17): 2883-5, 2003 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-14611849
20.
Indanyl piperazines as melatonergic MT2 selective agents.
Bioorg Med Chem Lett
; 13(6): 1199-202, 2003 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-12643943