Detalhe da pesquisa
1.
Exploration of a Large Virtual Chemical Space: Identification of Potent Inhibitors of Lactate Dehydrogenase-A against Pancreatic Cancer.
J Chem Inf Model
; 63(3): 1028-1043, 2023 02 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36646658
2.
Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure-activity relationship, in vitro and in vivo evaluation as antitumor agents.
Bioorg Med Chem Lett
; 41: 127923, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33705908
3.
Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer.
Bioorg Med Chem
; 35: 116061, 2021 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33647840
4.
The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity.
Bioorg Med Chem
; 29: 115887, 2021 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33310545
5.
Design, synthesis and preclinical evaluation of 5-methyl-N4-aryl-furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential.
Bioorg Med Chem Lett
; 28(18): 3085-3093, 2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30098869
6.
Interleukin (IL)-6 modulates transforming growth factor-ß receptor I and II (TGF-ßRI and II) function in epidermal keratinocytes.
Exp Dermatol
; 26(8): 697-704, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27892604
7.
Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.
Bioorg Med Chem Lett
; 27(7): 1602-1607, 2017 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28258797
8.
Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents.
Bioorg Med Chem
; 25(2): 545-556, 2017 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27894589
9.
A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer.
J Pharmacol Exp Ther
; 353(2): 392-404, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25720766
10.
A new anti-glioma therapy, AG119: pre-clinical assessment in a mouse GL261 glioma model.
BMC Cancer
; 15: 522, 2015 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26177924
11.
Identification of novel drugs to target dormant micrometastases.
BMC Cancer
; 15: 404, 2015 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-25971923
12.
The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.
Bioorg Med Chem
; 23(10): 2408-23, 2015 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25882519
13.
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.
Bioorg Med Chem
; 22(14): 3753-72, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24890652
14.
Evaluation of 99mTc-probestin for imaging APN expressing tumors by SPECT.
Bioorg Med Chem Lett
; 23(18): 5049-52, 2013 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23937983
15.
Solid phase synthesis and biological evaluation of probestin as an angiogenesis inhibitor.
Bioorg Med Chem Lett
; 23(12): 3561-4, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23664876
16.
N2-Trimethylacetyl substituted and unsubstituted-N4-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines: design, cellular receptor tyrosine kinase inhibitory activities and in vivo evaluation as antiangiogenic, antimetastatic and antitumor agents.
Bioorg Med Chem
; 21(5): 1312-23, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23375090
17.
Synthesis and biological activity of 5-chloro-N4-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents.
Bioorg Med Chem
; 21(7): 1857-64, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23434139
18.
Precision nephrotoxicity testing using 3D in vitro models.
Cell Biosci
; 13(1): 231, 2023 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38129901
19.
Synthesis and evaluation of novel Tc-99m labeled probestin conjugates for imaging APN/CD13 expression in vivo.
Bioconjug Chem
; 23(1): 115-24, 2012 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22148582
20.
Synthesis and biodistribution studies of technetium-99m-labeled aminopeptidase N inhibitor conjugates.
Bioorg Med Chem Lett
; 22(14): 4567-70, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22727671