RESUMO
Dendritic cells (DCs) are bone marrow-derived, professional antigen-presenting cells, with inherent tolerogenic function. The ability of immature or maturation-resistant DCs to regulate alloantigen-specific T-cell responses and to promote tolerance induction has been well demonstrated in organ and bone marrow transplantation. Recent data suggest that DCs can also promote long-term survival of composite tissue allografts in the absence of continued immunosuppressive drug therapy.
Assuntos
Células Dendríticas/imunologia , Sobrevivência de Enxerto/fisiologia , Transplante de Tecidos/patologia , Transplante Homólogo/imunologia , Células da Medula Óssea/imunologia , Células Dendríticas/transplante , Humanos , Tolerância Imunológica , Terapia de Imunossupressão/métodos , Imunossupressores/uso terapêutico , Baço/imunologia , Linfócitos T/imunologia , Transplante Homólogo/patologiaRESUMO
We report on a three-year-old girl with a severely enlarged right ring finger, which was diagnosed as macrodactyly simplex congenita. This was treated by epiphysial resection and osteosynthesis of the distal interphalangeal joint, longitudinal and transverse osteotomy of the phalanges, and soft tissue coverage using palmar proximal and dorsal distal flaps taken from the original oversised finger.