Detalhe da pesquisa
1.
Targeting TNFα produced by astrocytes expressing amyotrophic lateral sclerosis-linked mutant fused in sarcoma prevents neurodegeneration and motor dysfunction in mice.
Glia
; 70(7): 1426-1449, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35474517
2.
Therapeutic AAV9-mediated suppression of mutant SOD1 slows disease progression and extends survival in models of inherited ALS.
Mol Ther
; 21(12): 2148-59, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24008656
3.
Advances in molecular pathology, diagnosis, and treatment of amyotrophic lateral sclerosis.
BMJ
; 383: e075037, 2023 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37890889
4.
Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death.
Proc Natl Acad Sci U S A
; 105(34): 12599-604, 2008 Aug 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-18719118
5.
Increased synthesis of pro-inflammatory cytokines in C9ORF72 patients.
Amyotroph Lateral Scler Frontotemporal Degener
; 22(7-8): 517-527, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33929933
6.
Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis.
Elife
; 82019 02 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30747709
7.
Increased ER stress during motor neuron degeneration in a transgenic mouse model of amyotrophic lateral sclerosis.
Neurol Res
; 29(8): 767-71, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17672929
8.
Motoneuron Disease: Basic Science.
Adv Neurobiol
; 15: 163-190, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28674981
9.
Motoneuron Disease: Clinical.
Adv Neurobiol
; 15: 191-210, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28674982
10.
Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS.
EMBO Mol Med
; 8(12): 1421-1437, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27821430
11.
Therapeutic benefit of intrathecal injection of insulin-like growth factor-1 in a mouse model of Amyotrophic Lateral Sclerosis.
J Neurol Sci
; 235(1-2): 61-8, 2005 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15990113
12.
Valproic acid and zonisamide induced hyperammonemic encephalopathy.
Clin Neurol Neurosurg
; 196: 105894, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32645624
13.
Hypoxic induction of vascular endothelial growth factor is selectively impaired in mice carrying the mutant SOD1 gene.
Brain Res
; 989(2): 231-7, 2003 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-14556945
14.
Change in superoxide dismutase 1 protein localization towards mitochondria: an immunohistochemical study in transgenic G93A mice.
Neurosci Lett
; 332(1): 53-6, 2002 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-12377383
15.
Sustained induction of survival p-AKT and p-ERK signals after transient hypoxia in mice spinal cord with G93A mutant human SOD1 protein.
J Neurol Sci
; 215(1-2): 57-62, 2003 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-14568129
16.
Age-related changes in peroxisomal membrane protein 70 and superoxide dismutase 1 in transgenic G93A mice.
Neurol Res
; 25(4): 423-6, 2003 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12870272
17.
Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS.
Neuron
; 67(4): 575-87, 2010 Aug 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20797535
18.
Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond.
J Cell Biol
; 187(6): 761-72, 2009 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19951898
19.
Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells.
J Clin Invest
; 119(11): 3437-49, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19841542
20.
Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS.
PLoS One
; 3(8): e2849, 2008 Aug 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-18682740