Detalhe da pesquisa
1.
Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity.
Nat Chem Biol
; 17(11): 1157-1167, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34675414
2.
Transformation of naltrexone into mesembrane and investigation of the binding properties of its intermediate derivatives to opioid receptors.
Bioorg Med Chem
; 23(3): 439-48, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25573119
3.
Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 2: synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies.
Bioorg Med Chem Lett
; 22(15): 5071-4, 2012 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22742909
4.
Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 3: synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies.
Bioorg Med Chem Lett
; 22(24): 7711-4, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23103094
5.
Essential structure of opioid κ receptor agonist nalfurafine for binding to κ receptor 1: synthesis of decahydroisoquinoline derivatives and their pharmacologies.
Chem Pharm Bull (Tokyo)
; 60(8): 945-8, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22863695
6.
Discovery of Benzo[d]imidazole-6-sulfonamides as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain.
ChemMedChem
; 17(20): e202200343, 2022 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36040095
7.
Synthesis of (-)-homogalanthamine from naltrexone.
J Org Chem
; 76(7): 2257-60, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21381712
8.
A double decarboxylation reaction of an oxazolidinone and carboxylic Acid: its application to the synthesis of a new opioid lead compound.
J Org Chem
; 75(3): 995-8, 2010 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20070096
9.
Investigation of Beckett-Casy model 2: synthesis of novel 15-16 nornaltrexone derivatives and their pharmacology.
Bioorg Med Chem Lett
; 20(12): 3726-9, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20483601
10.
Investigation of Beckett-Casy model 1: synthesis of novel 16,17-seco-naltrexone derivatives and their pharmacology.
Bioorg Med Chem Lett
; 20(3): 1055-8, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20056539
11.
Investigation of Beckett-Casy model 3: synthesis of novel naltrexone derivatives with contracted and expanded D-rings and their pharmacology.
Bioorg Med Chem Lett
; 20(12): 3801-4, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20478707
12.
Discovery and SAR Studies of Orally Active Somatostatin Receptor Subtype-2 (SSTR2) Agonists for the Treatment of Acromegaly.
ACS Chem Neurosci
; 11(10): 1482-1494, 2020 05 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32315148