Detalhe da pesquisa
1.
Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity.
Cell
; 168(5): 867-877.e13, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28235198
2.
Click Chemistry: Reaction Rates and Their Suitability for Biomedical Applications.
Bioconjug Chem
; 2024 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38775705
3.
Assessment of the Molecular Mechanisms of Action of Novel 4-Phenylpyridine-2-One and 6-Phenylpyrimidin-4-One Allosteric Modulators at the M1 Muscarinic Acetylcholine Receptors.
Mol Pharmacol
; 94(1): 770-783, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29691279
4.
Chemical biology-based approaches to study adenosine A2A - dopamine D2 receptor heteromers.
Purinergic Signal
; 18(4): 395-398, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35348986
5.
Novel adenosine A(2A) receptor ligands: a synthetic, functional and computational investigation of selected literature adenosine A(2A) receptor antagonists for extending into extracellular space.
Bioorg Med Chem Lett
; 23(11): 3427-33, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23602401
6.
The application of targeted protein degradation technologies to G protein-coupled receptors.
Br J Pharmacol
; 2023 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36965004
7.
Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M4 mAChR.
Eur J Med Chem
; 258: 115588, 2023 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37423123
8.
The Design, Synthesis, and Evaluation of Novel 9-Arylxanthenedione-Based Allosteric Modulators for the δ-Opioid Receptor.
J Med Chem
; 65(18): 12367-12385, 2022 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36099150
9.
Examining the Role of the Linker in Bitopic N6-Substituted Adenosine Derivatives Acting as Biased Adenosine A1 Receptor Agonists.
J Med Chem
; 65(13): 9076-9095, 2022 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35729775
10.
The right tools for the job: the central role for next generation chemical probes and chemistry-based target deconvolution methods in phenotypic drug discovery.
RSC Med Chem
; 12(5): 646-665, 2021 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34124668
11.
New small molecule fluorescent probes for G protein-coupled receptors: valuable tools for drug discovery.
Future Med Chem
; 13(1): 63-90, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33319586
12.
Development of Novel 4-Arylpyridin-2-one and 6-Arylpyrimidin-4-one Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor.
ChemMedChem
; 16(1): 216-233, 2021 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32851779
13.
The effect of two selective A1 -receptor agonists and the bitopic ligand VCP746 on heart rate and regional vascular conductance in conscious rats.
Br J Pharmacol
; 177(2): 346-359, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31596949
14.
NMR case study of ropinirole: concentration-dependent effects of nonexchangeable proton resonances.
Magn Reson Chem
; 52(11): 715-8, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25104507
15.
Probe dependence of allosteric enhancers on the binding affinity of adenosine A1 -receptor agonists at rat and human A1 -receptors measured using NanoBRET.
Br J Pharmacol
; 176(7): 864-878, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30644086
16.
6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity.
ACS Chem Neurosci
; 10(3): 1099-1114, 2019 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30547573
17.
Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor.
Biochem Pharmacol
; 154: 243-254, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29777683
18.
Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor with Weak Agonist Activity and Diverse Modulatory Profiles.
J Med Chem
; 61(7): 2875-2894, 2018 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29544056
19.
A Structure-Activity Relationship Study of Bitopic N6-Substituted Adenosine Derivatives as Biased Adenosine A1 Receptor Agonists.
J Med Chem
; 61(5): 2087-2103, 2018 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29446948
20.
Guidelines for the Synthesis of Small-Molecule Irreversible Probes Targeting Gâ Protein-Coupled Receptors.
ChemMedChem
; 11(14): 1488-98, 2016 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27347648