Detalhe da pesquisa
1.
Metabolic control of TFH cells and humoral immunity by phosphatidylethanolamine.
Nature
; 595(7869): 724-729, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34234346
2.
Pantothenate Kinase Activation Restores Brain Coenzyme A in a Mouse Model of Pantothenate Kinase-Associated Neurodegeneration.
J Pharmacol Exp Ther
; 388(1): 171-180, 2024 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37875310
3.
Relief of CoA sequestration and restoration of mitochondrial function in a mouse model of propionic acidemia.
J Inherit Metab Dis
; 46(1): 28-42, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36251252
4.
Proton magnetic resonance spectroscopy detects cerebral metabolic derangement in a mouse model of brain coenzyme a deficiency.
J Transl Med
; 20(1): 103, 2022 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35197056
5.
Cardiac PANK1 deletion exacerbates ventricular dysfunction during pressure overload.
Am J Physiol Heart Circ Physiol
; 321(4): H784-H797, 2021 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34533403
6.
Rational Design of Novel Therapies for Pantothenate Kinase-Associated Neurodegeneration.
Mov Disord
; 36(9): 2005-2016, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34002881
7.
LipE guided discovery of isopropylphenyl pyridazines as pantothenate kinase modulators.
Bioorg Med Chem
; 52: 116504, 2021 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34814071
8.
T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions.
J Biol Chem
; 292(1): 15-30, 2017 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27903651
9.
Allosteric Regulation of Mammalian Pantothenate Kinase.
J Biol Chem
; 291(42): 22302-22314, 2016 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27555321
10.
Excess coenzyme A reduces skeletal muscle performance and strength in mice overexpressing human PANK2.
Mol Genet Metab
; 120(4): 350-362, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28189602
11.
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis.
EMBO J
; 30(7): 1357-75, 2011 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-21407177
12.
Correction of a genetic deficiency in pantothenate kinase 1 using phosphopantothenate replacement therapy.
Mol Genet Metab
; 116(4): 281-8, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26549575
13.
Pank1 deletion in leptin-deficient mice reduces hyperglycaemia and hyperinsulinaemia and modifies global metabolism without affecting insulin resistance.
Diabetologia
; 57(7): 1466-75, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24781151
14.
Phosphatidylcholine and the CDP-choline cycle.
Biochim Biophys Acta
; 1831(3): 523-32, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23010477
15.
Deregulated coenzyme A, loss of metabolic flexibility and diabetes.
Biochem Soc Trans
; 42(4): 1118-22, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25110012
16.
Coenzyme A and its derivatives: renaissance of a textbook classic.
Biochem Soc Trans
; 42(4): 1025-32, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25109997
17.
Physiological roles of the pantothenate kinases.
Biochem Soc Trans
; 42(4): 1033-6, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25109998
18.
Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation.
J Biol Chem
; 287(18): 14615-20, 2012 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22442146
19.
PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing.
Nat Metab
; 5(3): 495-515, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36941451
20.
Phosphatidylcholine biosynthesis during neuronal differentiation and its role in cell fate determination.
J Biol Chem
; 285(33): 25382-93, 2010 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-20525991