Detalhe da pesquisa
1.
Use of pyrrolobenzodiazepines and related covalent-binding DNA-interactive molecules as ADC payloads: Is mechanism related to systemic toxicity?
Drug Discov Today Technol
; 30: 71-83, 2018 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-30553523
2.
The use of molecular dynamics simulations to evaluate the DNA sequence-selectivity of G-A cross-linking PBD-duocarmycin dimers.
Bioorg Med Chem Lett
; 27(1): 102-108, 2017 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27889454
3.
From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs).
Angew Chem Int Ed Engl
; 56(2): 462-488, 2017 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27862776
4.
Effect of hairpin loop structure on reactivity, sequence preference and adduct orientation of a DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumour agent.
Org Biomol Chem
; 13(13): 4031-40, 2015 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25733051
5.
Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells.
Org Biomol Chem
; 13(13): 3882-6, 2015 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25721973
6.
Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry.
Bioorg Med Chem Lett
; 23(16): 4719-22, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23810499
7.
DNA sequence-selective G-A cross-linking ADC payloads for use in solid tumour therapies.
Commun Biol
; 5(1): 741, 2022 07 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-35906376
8.
UPLC-based assay to assess the hydrophobicity of Antibody-Drug Conjugate (ADC) payloads.
J Chromatogr B Analyt Technol Biomed Life Sci
; 1146: 122075, 2020 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32361467
9.
A Novel Antibody-Drug Conjugate (ADC) Delivering a DNA Mono-Alkylating Payload to Chondroitin Sulfate Proteoglycan (CSPG4)-Expressing Melanoma.
Cancers (Basel)
; 12(4)2020 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32331483
10.
Sequence-selective binding of C8-conjugated pyrrolobenzodiazepines (PBDs) to DNA.
Biophys Chem
; 230: 53-61, 2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28941814
11.
Covalent Bonding of Pyrrolobenzodiazepines (PBDs) to Terminal Guanine Residues within Duplex and Hairpin DNA Fragments.
PLoS One
; 11(4): e0152303, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27055050
12.
Computational studies support the role of the C7-sibirosamine sugar of the pyrrolobenzodiazepine (PBD) sibiromycin in transcription factor inhibition.
ACS Chem Biol
; 9(10): 2432-40, 2014 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25111266
13.
Pyrrolobenzodiazepines (PBDs) do not bind to DNA G-quadruplexes.
PLoS One
; 9(8): e105021, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25133504
14.
GC-targeted C8-linked pyrrolobenzodiazepine-biaryl conjugates with femtomolar in vitro cytotoxicity and in vivo antitumor activity in mouse models.
J Med Chem
; 56(7): 2911-35, 2013 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23514599
15.
An extended pyrrolobenzodiazepine-polyamide conjugate with selectivity for a DNA sequence containing the ICB2 transcription factor binding site.
J Med Chem
; 56(16): 6339-51, 2013 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23889553