Pesquisa | Biblioteca Virtual em Saúde

1.

Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease.

Kron, Jarrah O-Z J; Keenan, Ryan J; Hoyer, Daniel; Jacobson, Laura H.

Annu Rev Pharmacol Toxicol ; 64: 359-386, 2024 Jan 23.

Artigo em Inglês | MEDLINE | ID: mdl-37708433

2.

Default Mode Network Modulation by Psychedelics: A Systematic Review.

Gattuso, James J; Perkins, Daniel; Ruffell, Simon; Lawrence, Andrew J; Hoyer, Daniel; Jacobson, Laura H; Timmermann, Christopher; Castle, David; Rossell, Susan L; Downey, Luke A; Pagni, Broc A; Galvão-Coelho, Nicole L; Nutt, David; Sarris, Jerome.

Int J Neuropsychopharmacol ; 26(3): 155-188, 2023 03 22.

Artigo em Inglês | MEDLINE | ID: mdl-36272145

3.

Hypocretins (orexins): The ultimate translational neuropeptides.

Jacobson, Laura H; Hoyer, Daniel; de Lecea, Luis.

J Intern Med ; 291(5): 533-556, 2022 05.

Artigo em Inglês | MEDLINE | ID: mdl-35043499

4.

Selective Na_V1.1 activation rescues Dravet syndrome mice from seizures and premature death.

Richards, Kay L; Milligan, Carol J; Richardson, Robert J; Jancovski, Nikola; Grunnet, Morten; Jacobson, Laura H; Undheim, Eivind A B; Mobli, Mehdi; Chow, Chun Yuen; Herzig, Volker; Csoti, Agota; Panyi, Gyorgy; Reid, Christopher A; King, Glenn F; Petrou, Steven.

Proc Natl Acad Sci U S A ; 115(34): E8077-E8085, 2018 08 21.

Artigo em Inglês | MEDLINE | ID: mdl-30076230

5.

Novel alterations in corneal neuroimmune phenotypes in mice with central nervous system tauopathy.

Jiao, Haihan; Downie, Laura E; Huang, Xin; Wu, Mengliang; Oberrauch, Sara; Keenan, Ryan J; Jacobson, Laura H; Chinnery, Holly R.

J Neuroinflammation ; 17(1): 136, 2020 Apr 28.

Artigo em Inglês | MEDLINE | ID: mdl-32345316

6.

Hypnotics with novel modes of action.

Hoyer, Daniel; Allen, Andrew; Jacobson, Laura H.

Br J Clin Pharmacol ; 86(2): 244-249, 2020 02.

Artigo em Inglês | MEDLINE | ID: mdl-31756268

7.

Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs).

Behnke, Dirk; Cotesta, Simona; Hintermann, Samuel; Fendt, Markus; Gee, Christine E; Jacobson, Laura H; Laue, Grit; Meyer, Arndt; Wagner, Trixie; Badiger, Sangamesh; Chaudhari, Vinod; Chebrolu, Murali; Pandit, Chetan; Hoyer, Daniel; Betschart, Claudia.

Bioorg Med Chem Lett ; 25(23): 5555-60, 2015 Dec 01.

Artigo em Inglês | MEDLINE | ID: mdl-26522950

8.

Enhanced proteolytic clearance of plasma Aß by peripherally administered neprilysin does not result in reduced levels of brain Aß in mice.

Walker, John R; Pacoma, Reynand; Watson, James; Ou, Weijia; Alves, Juliano; Mason, Daniel E; Peters, Eric C; Urbina, Hugo D; Welzel, Gus; Althage, Alana; Liu, Bo; Tuntland, Tove; Jacobson, Laura H; Harris, Jennifer L; Schumacher, Andrew M.

J Neurosci ; 33(6): 2457-64, 2013 Feb 06.

Artigo em Inglês | MEDLINE | ID: mdl-23392674

9.

Orexin 2 receptor antagonism sex-dependently improves sleep/wakefulness and cognitive performance in tau transgenic mice.

Keenan, Ryan J; Daykin, Heather; Metha, Jeremy; Cornthwaite-Duncan, Linda; Wright, David K; Clarke, Kyra; Oberrauch, Sara; Brian, Maddison; Stephenson, Sarah; Nowell, Cameron J; Allocca, Giancarlo; Barnham, Kevin J; Hoyer, Daniel; Jacobson, Laura H.

Br J Pharmacol ; 181(1): 87-106, 2024 01.

Artigo em Inglês | MEDLINE | ID: mdl-37553894

10.

Altered EEG power spectrum, but not sleep-wake architecture, in HCN1 knockout mice.

Bleakley, Lauren E; Keenan, Ryan J; Graven, Rachel D; Metha, Jeremy A; Ma, Sherie; Daykin, Heather; Cornthwaite-Duncan, Linda; Hoyer, Daniel; Reid, Christopher A; Jacobson, Laura H.

Behav Brain Res ; 437: 114105, 2023 02 02.

Artigo em Inglês | MEDLINE | ID: mdl-36089097

11.

The second-generation active Aß immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects.

Wiessner, Christoph; Wiederhold, Karl-Heinz; Tissot, Alain C; Frey, Peter; Danner, Simone; Jacobson, Laura H; Jennings, Gary T; Lüönd, Rainer; Ortmann, Rainer; Reichwald, Julia; Zurini, Mauro; Mir, Anis; Bachmann, Martin F; Staufenbiel, Matthias.

J Neurosci ; 31(25): 9323-31, 2011 Jun 22.

Artigo em Inglês | MEDLINE | ID: mdl-21697382

12.

Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation.

Eisele, Yvonne S; Bolmont, Tristan; Heikenwalder, Mathias; Langer, Franziska; Jacobson, Laura H; Yan, Zheng-Xin; Roth, Klaus; Aguzzi, Adriano; Staufenbiel, Matthias; Walker, Lary C; Jucker, Mathias.

Proc Natl Acad Sci U S A ; 106(31): 12926-31, 2009 Aug 04.

Artigo em Inglês | MEDLINE | ID: mdl-19622727

13.

Losing sleep with age.

Jacobson, Laura H; Hoyer, Daniel.

Science ; 375(6583): 816-817, 2022 02 25.

Artigo em Inglês | MEDLINE | ID: mdl-35201892

14.

Orexin Signaling: A Complex, Multifaceted Process.

Dale, Natasha C; Hoyer, Daniel; Jacobson, Laura H; Pfleger, Kevin D G; Johnstone, Elizabeth K M.

Front Cell Neurosci ; 16: 812359, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-35496914

15.

Differential sleep/wake response and sex differences following acute suvorexant, MK-1064 and zolpidem administration in the rTg4510 mouse model of tauopathy.

Keenan, Ryan J; Daykin, Heather; Chu, Jiahui; Cornthwaite-Duncan, Linda; Allocca, Giancarlo; Hoyer, Daniel; Jacobson, Laura H.

Br J Pharmacol ; 179(13): 3403-3417, 2022 07.

Artigo em Inglês | MEDLINE | ID: mdl-35112344

16.

Manipulation of rapid eye movement sleep via orexin and GABAA receptor modulators differentially affects fear extinction in mice: effect of stable versus disrupted circadian rhythm.

Clark, Jacob W; Daykin, Heather; Metha, Jeremy A; Allocca, Giancarlo; Hoyer, Daniel; Drummond, Sean P A; Jacobson, Laura H.

Sleep ; 44(9)2021 09 13.

Artigo em Inglês | MEDLINE | ID: mdl-33720375

17.

Decreased Orexin Receptor 1 mRNA Expression in the Locus Coeruleus in Both Tau Transgenic rTg4510 and Tau Knockout Mice and Accompanying Ascending Arousal System Tau Invasion in rTg4510.

Keenan, Ryan J; Oberrauch, Sara; Bron, Romke; Nowell, Cameron J; Challis, Leesa M; Hoyer, Daniel; Jacobson, Laura H.

J Alzheimers Dis ; 79(2): 693-708, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33361602

18.

Synthesis of the Potent, Selective, and Efficacious ß-Secretase (BACE1) Inhibitor NB-360.

Rueeger, Heinrich; Lueoend, Rainer; Machauer, Rainer; Veenstra, Siem J; Holzer, Philipp; Hurth, Konstanze; Voegtle, Markus; Frederiksen, Mathias; Rondeau, Jean-Michel; Tintelnot-Blomley, Marina; Jacobson, Laura H; Staufenbiel, Matthias; Laue, Grit; Neumann, Ulf.

J Med Chem ; 64(8): 4677-4696, 2021 04 22.

Artigo em Inglês | MEDLINE | ID: mdl-33844524

19.

Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious ß-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer's Disease.

Machauer, Rainer; Lueoend, Rainer; Hurth, Konstanze; Veenstra, Siem J; Rueeger, Heinrich; Voegtle, Markus; Tintelnot-Blomley, Marina; Rondeau, Jean-Michel; Jacobson, Laura H; Laue, Grit; Beltz, Karen; Neumann, Ulf.

J Med Chem ; 64(20): 15262-15279, 2021 10 28.

Artigo em Inglês | MEDLINE | ID: mdl-34648711

20.

Reward motivation and cognitive flexibility in tau null-mutation mice.

Oberrauch, Sara; Metha, Jeremy A; Brian, Maddison L; Barnes, Samuel A; Featherby, Travis J; Lawrence, Andrew J; Hoyer, Daniel; Murawski, Carsten; Jacobson, Laura H.

Neurobiol Aging ; 100: 106-117, 2021 04.

Artigo em Inglês | MEDLINE | ID: mdl-33524848

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