Detalhe da pesquisa
1.
Gasdermin D pore structure reveals preferential release of mature interleukin-1.
Nature
; 593(7860): 607-611, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33883744
2.
BCR::ABL1 Kinase N-lobe Mutants Confer Moderate to High Degrees of Resistance to Asciminib.
Blood
; 2024 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38643492
3.
Synthetic group A streptogramin antibiotics that overcome Vat resistance.
Nature
; 586(7827): 145-150, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32968273
4.
Signal peptide mimicry primes Sec61 for client-selective inhibition.
Nat Chem Biol
; 19(9): 1054-1062, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37169961
5.
Cysteine Oxidation in Proteins: Structure, Biophysics, and Simulation.
Biochemistry
; 61(20): 2165-2176, 2022 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36161872
6.
Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response.
PLoS Genet
; 15(8): e1008295, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31398187
7.
In Vitro Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase-2.
Biochemistry
; 60(22): 1741-1754, 2021 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34029049
8.
Mutagenesis, Hydrogen-Deuterium Exchange, and Molecular Docking Investigations Establish the Dimeric Interface of Human Platelet-Type 12-Lipoxygenase.
Biochemistry
; 60(10): 802-812, 2021 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33635645
9.
Synthesis and Screening of α-Xylosides in Human Glioblastoma Cells.
Mol Pharm
; 18(1): 451-460, 2021 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33315406
10.
Docking and mutagenesis studies lead to improved inhibitor development of ML355 for human platelet 12-lipoxygenase.
Bioorg Med Chem
; 46: 116347, 2021 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34507163
11.
Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
Bioorg Med Chem
; 46: 116349, 2021 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34500187
12.
Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators.
Biochemistry
; 59(19): 1832-1844, 2020 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32324389
13.
Role of Human 15-Lipoxygenase-2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase-1.
Biochemistry
; 59(42): 4118-4130, 2020 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33048542
14.
15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5.
J Lipid Res
; 61(7): 1087-1103, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32404334
15.
Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH.
J Biol Chem
; 294(22): 8779-8790, 2019 05 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-30992364
16.
Conformational Dynamics of the HIV-Vif Protein Complex.
Biophys J
; 116(8): 1432-1445, 2019 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30961890
17.
Multi-Granulin Domain Peptides Bind to Pro-Cathepsin D and Stimulate Its Enzymatic Activity More Effectively Than Progranulin in Vitro.
Biochemistry
; 58(23): 2670-2674, 2019 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31099551
18.
Probing the Electrostatic and Steric Requirements for Substrate Binding in Human Platelet-Type 12-Lipoxygenase.
Biochemistry
; 58(6): 848-857, 2019 02 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30565457
19.
High-throughput screen for inhibitors of protein-protein interactions in a reconstituted heat shock protein 70 (Hsp70) complex.
J Biol Chem
; 293(11): 4014-4025, 2018 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29414793
20.
Structure-based identification of novel CK2 inhibitors with a linear 2-propenone scaffold as anti-cancer agents.
Biochem Biophys Res Commun
; 512(2): 208-212, 2019 04 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-30878184