Detalhe da pesquisa
1.
Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.
Cell
; 161(6): 1252-65, 2015 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26046436
2.
NCATS Inxight Drugs: a comprehensive and curated portal for translational research.
Nucleic Acids Res
; 50(D1): D1307-D1316, 2022 01 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34648031
3.
A quantitative high-throughput screen identifies compounds that lower expression of the SCA2-and ALS-associated gene ATXN2.
J Biol Chem
; 298(8): 102228, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35787375
4.
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Proc Natl Acad Sci U S A
; 117(49): 31365-31375, 2020 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33229545
5.
The AKT modulator A-443654 reduces α-synuclein expression and normalizes ER stress and autophagy.
J Biol Chem
; 297(4): 101191, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34520759
6.
KDM5 histone demethylases repress immune response via suppression of STING.
PLoS Biol
; 16(8): e2006134, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30080846
7.
Optimization of ether and aniline based inhibitors of lactate dehydrogenase.
Bioorg Med Chem Lett
; 41: 127974, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33771585
8.
Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
Bioorg Med Chem
; 46: 116349, 2021 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34500187
9.
Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.
Nature
; 522(7555): 216-20, 2015 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25896324
10.
High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2.
J Biol Chem
; 293(35): 13750-13765, 2018 08 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-29945974
11.
Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.
FASEB J
; 32(3): 1677-1691, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29146736
12.
Lead optimization and efficacy evaluation of quinazoline-based BET family inhibitors for potential treatment of cancer and inflammatory diseases.
Bioorg Med Chem Lett
; 29(10): 1220-1226, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30905542
13.
Scaffold-Based Analytics: Enabling Hit-to-Lead Decisions by Visualizing Chemical Series Linked across Large Datasets.
J Chem Inf Model
; 59(11): 4880-4892, 2019 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31532656
14.
Varied Role of Ubiquitylation in Generating MHC Class I Peptide Ligands.
J Immunol
; 198(10): 3835-3845, 2017 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28363906
15.
Pharos: Collating protein information to shed light on the druggable genome.
Nucleic Acids Res
; 45(D1): D995-D1002, 2017 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27903890
16.
A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation.
Proc Natl Acad Sci U S A
; 113(50): 14366-14371, 2016 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28182563
17.
First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis.
Arterioscler Thromb Vasc Biol
; 37(10): 1828-1839, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28775075
18.
Discovery and lead identification of quinazoline-based BRD4 inhibitors.
Bioorg Med Chem Lett
; 28(21): 3483-3488, 2018 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30268702
19.
Identifying hotspots in land use land cover change and the drivers in a semi-arid region of India.
Environ Monit Assess
; 190(9): 535, 2018 Aug 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30128752
20.
Lecithin:Cholesterol Acyltransferase Activation by Sulfhydryl-Reactive Small Molecules: Role of Cysteine-31.
J Pharmacol Exp Ther
; 362(2): 306-318, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28576974