Detalhe da pesquisa
1.
Degron mediated BRM/SMARCA2 depletion uncovers novel combination partners for treatment of BRG1/SMARCA4-mutant cancers.
Biochem Biophys Res Commun
; 508(1): 109-116, 2019 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30527810
2.
Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers.
Proc Natl Acad Sci U S A
; 111(8): 3128-33, 2014 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24520176
3.
Exquisite Sensitivity to Dual BRG1/BRM ATPase Inhibitors Reveals Broad SWI/SNF Dependencies in Acute Myeloid Leukemia.
Mol Cancer Res
; 20(3): 361-372, 2022 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34799403
4.
Mammalian SWI/SNF continuously restores local accessibility to chromatin.
Nat Genet
; 53(3): 279-287, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33558757
5.
The Discovery of SWI/SNF Chromatin Remodeling Activity as a Novel and Targetable Dependency in Uveal Melanoma.
Mol Cancer Ther
; 19(10): 2186-2195, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32747420
6.
FoxO tumor suppressors and BCR-ABL-induced leukemia: a matter of evasion of apoptosis.
Biochim Biophys Acta
; 1785(1): 63-84, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17980712
7.
Cancer stem cells and impaired apoptosis.
Adv Exp Med Biol
; 615: 331-44, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18437901
8.
Apoptotic pathways in tumor progression and therapy.
Adv Exp Med Biol
; 615: 47-79, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18437891
9.
TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer.
Cell Rep
; 25(5): 1255-1267.e5, 2018 10 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-30380416
10.
Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers.
J Med Chem
; 61(22): 10155-10172, 2018 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30339381
11.
Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation.
Mol Cell Biol
; 34(6): 1136-44, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24421395
12.
ARID1B is a specific vulnerability in ARID1A-mutant cancers.
Nat Med
; 20(3): 251-4, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24562383
13.
Unraveling the therapeutic potential of the Hedgehog pathway in cancer.
Nat Med
; 19(11): 1410-22, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24202394
14.
Fibroblast growth factor receptors as novel therapeutic targets in SNF5-deleted malignant rhabdoid tumors.
PLoS One
; 8(10): e77652, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24204904
15.
Hedgehog pathway activation in chronic myeloid leukemia.
Cell Cycle
; 9(17): 3449-56, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20928937
16.
The Polycomb group protein Bmi-1 is essential for the growth of multiple myeloma cells.
Cancer Res
; 70(13): 5528-38, 2010 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20530672
17.
Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway.
Nat Med
; 16(12): 1429-33, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21076395
18.
PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers.
Cancer Res
; 69(10): 4286-93, 2009 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19401449
19.
Proteasome inhibition causes regression of leukemia and abrogates BCR-ABL-induced evasion of apoptosis in part through regulation of forkhead tumor suppressors.
Cancer Res
; 69(16): 6546-55, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19654305
20.
Cytokines and BCR-ABL mediate suppression of TRAIL-induced apoptosis through inhibition of forkhead FOXO3a transcription factor.
Proc Natl Acad Sci U S A
; 100(11): 6523-8, 2003 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-12750477