Detalhe da pesquisa
1.
H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2.
Mol Cell
; 80(4): 726-735.e7, 2020 11 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33049227
2.
Continued Activity of the Pioneer Factor Zelda Is Required to Drive Zygotic Genome Activation.
Mol Cell
; 74(1): 185-195.e4, 2019 04 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30797686
3.
Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression.
Proc Natl Acad Sci U S A
; 117(44): 27354-27364, 2020 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33067396
4.
Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase.
Proc Natl Acad Sci U S A
; 116(17): 8295-8300, 2019 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30967505
5.
S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
Proc Natl Acad Sci U S A
; 113(22): 6182-7, 2016 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-27185940
6.
Strategy for "detoxification" of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2.
J Am Chem Soc
; 136(39): 13498-501, 2014 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25180930
7.
H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone.
Cancer Discov
; 10(12): 1968-1987, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32967858
8.
PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism.
Nat Commun
; 10(1): 2146, 2019 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31086175
9.
H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis.
Nat Commun
; 10(1): 1262, 2019 03 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30890717
10.
Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas.
Sci Transl Med
; 8(366): 366ra161, 2016 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27881822
11.
Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape.
Science
; 352(6287): 844-9, 2016 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27174990