Detalhe da pesquisa
1.
Pharmacokinetic-pharmacodynamic guided optimisation of dose and schedule of CGM097, an HDM2 inhibitor, in preclinical and clinical studies.
Br J Cancer
; 125(5): 687-698, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34140638
2.
Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf-/- mouse model.
Proc Natl Acad Sci U S A
; 114(12): 3151-3156, 2017 03 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28265066
3.
The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1.
Neuroendocrinology
; 106(1): 1-19, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-27871087
4.
In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor.
Bioorg Med Chem Lett
; 28(20): 3404-3408, 2018 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30217415
5.
Discovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument.
Bioorg Med Chem Lett
; 26(19): 4837-4841, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27542305
6.
Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors.
Bioorg Med Chem Lett
; 26(8): 2057-64, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26951753
7.
Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode.
Bioorg Med Chem Lett
; 25(17): 3621-5, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26141769
8.
Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition.
Proc Natl Acad Sci U S A
; 109(20): E1267-76, 2012 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22529373
9.
Design of Dual EP2/EP4 Antagonists through Scaffold Merging of Selective Inhibitors.
ChemMedChem
; 19(2): e202300606, 2024 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37983645
10.
Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
J Med Chem
; 65(7): 5317-5333, 2022 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35352560
11.
The tumor suppressor activity of the lysyl oxidase propeptide reverses the invasive phenotype of Her-2/neu-driven breast cancer.
Cancer Res
; 67(3): 1105-12, 2007 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17283144
12.
c-Myc represses FOXO3a-mediated transcription of the gene encoding the p27(Kip1) cyclin dependent kinase inhibitor.
J Cell Biochem
; 104(6): 2091-106, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18393360
13.
Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53-MDM2 Inhibitor HDM201.
Cancer Res
; 78(21): 6257-6267, 2018 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30135191
14.
Lysyl oxidase inhibits ras-mediated transformation by preventing activation of NF-kappa B.
Mol Cell Biol
; 23(7): 2251-63, 2003 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-12640111
15.
Combined ALK and MDM2 inhibition increases antitumor activity and overcomes resistance in human ALK mutant neuroblastoma cell lines and xenograft models.
Elife
; 62017 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28425916
16.
A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma.
Cell Rep
; 21(7): 1953-1967, 2017 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29141225
17.
High-Order Drug Combinations Are Required to Effectively Kill Colorectal Cancer Cells.
Cancer Res
; 76(23): 6950-6963, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27659046
18.
Dual inhibition of protein kinase C and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma.
Oncotarget
; 7(23): 33542-56, 2016 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27507190
19.
The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.
Cancer Cell
; 29(4): 574-586, 2016 04 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27070704
20.
B-Myb repressor function is regulated by cyclin A phosphorylation and sequences within the C-terminal domain.
Oncogene
; 22(13): 2011-20, 2003 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-12673206