Detalhe da pesquisa
1.
Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors.
Bioorg Med Chem Lett
; 30(3): 126751, 2020 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31862412
2.
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.
J Med Chem
; 65(10): 7212-7230, 2022 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35536179
3.
Structural Analysis and Development of Notum Fragment Screening Hits.
ACS Chem Neurosci
; 13(13): 2060-2077, 2022 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35731924
4.
Highly specific, sensitive and rapid enzyme immunoassays for the measurement of acetaminophen in serum.
Anal Bioanal Chem
; 401(7): 2195-204, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21853346
5.
Detection of proteases using an immunochemical method with haptenylated-gelatin as a solid-phase substrate.
Anal Bioanal Chem
; 396(7): 2547-58, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20195581
6.
Characterization of bacterial proteases with a panel of fluorescent peptide substrates.
Anal Biochem
; 384(2): 321-8, 2009 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18957278
7.
Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.
Medchemcomm
; 10(8): 1361-1369, 2019 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31534655
8.
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.
Eur J Med Chem
; 177: 316-337, 2019 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31158747
9.
Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70.
J Med Chem
; 59(10): 4625-36, 2016 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27119979
10.
A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep
; 6: 34701, 2016 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27708405
11.
Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem Biol
; 11(11): 3093-3105, 2016 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27571355
12.
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.
J Med Chem
; 59(4): 1388-409, 2016 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26741168
13.
Optimisation of the detection of bacterial proteases using adsorbed immunoglobulins as universal substrates.
Talanta
; 81(4-5): 1237-44, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20441890
14.
Use of antibody-hapten complexes attached to optical sensor surfaces as a substrate for proteases: real-time biosensing of protease activity.
Talanta
; 81(1-2): 68-75, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20188889
15.
Labeling of biotin antibodies with horseradish peroxidase using cyanuric chloride.
Nat Protoc
; 4(4): 452-60, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19282850