Detalhe da pesquisa
1.
Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor.
EMBO J
; 27(14): 1985-94, 2008 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-18566589
2.
Novel 2-phenylquinolin-7-yl-derived imidazo[1,5-a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors.
Bioorg Med Chem
; 16(3): 1359-75, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17983756
3.
A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo.
Mol Cancer Ther
; 6(8): 2158-67, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17671083
4.
Phospholipase C-gamma1 is required for survival in heat stress: involvement of protein kinase C-dependent Bcl-2 phosphorylation.
J Biochem
; 131(2): 207-12, 2002 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-11820933
5.
Expression of phospholipase-gamma1 in human fetal tissues.
Di Yi Jun Yi Da Xue Xue Bao
; 21(12): 888-889, 2001.
Artigo
em Inglês
| MEDLINE | ID: mdl-12426156
6.
Inhibition of the IGF-I receptor for treatment of cancer. Kinase inhibitors and monoclonal antibodies as alternative approaches.
Recent Results Cancer Res
; 172: 59-76, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17607936
7.
Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor.
Future Med Chem
; 1(6): 1153-71, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21425998
8.
Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors.
Cancer Res
; 68(20): 8322-32, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18922904
9.
1,3-Disubstituted-imidazo[1,5-a]pyrazines as insulin-like growth-factor-I receptor (IGF-IR) inhibitors.
Bioorg Med Chem Lett
; 17(4): 1091-7, 2007 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17127062
10.
Identification of VEGFR3 gene mutation in a Chinese family with autosomal dominant primary congenital lymphoedema / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 371-375, 2010.
Artigo
em Zh
| WPRIM | ID: wpr-234402
11.
Phospholipase C-gamma1 is required for cell survival in oxidative stress by protein kinase C.
Biochem J
; 363(Pt 2): 395-401, 2002 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-11931670