Detalhe da pesquisa
1.
Translational Control by 4E-BP1/2 Suppressor Proteins Regulates Mitochondrial Biosynthesis and Function during CD8+ T Cell Proliferation.
J Immunol
; 208(12): 2702-2712, 2022 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35667842
2.
Venetoclax enhances T cell-mediated antileukemic activity by increasing ROS production.
Blood
; 138(3): 234-245, 2021 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34292323
3.
Mitochondrial carrier homolog 2 is necessary for AML survival.
Blood
; 136(1): 81-92, 2020 07 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32299104
4.
The thymidine dideoxynucleoside analog, alovudine, inhibits the mitochondrial DNA polymerase γ, impairs oxidative phosphorylation and promotes monocytic differentiation in acute myeloid leukemia.
Haematologica
; 104(5): 963-972, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30573504
5.
AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress.
Blood
; 125(13): 2120-30, 2015 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25631767
6.
Carnitine transporter CT2 (SLC22A16) is over-expressed in acute myeloid leukemia (AML) and target knockdown reduces growth and viability of AML cells.
Apoptosis
; 20(8): 1099-108, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25998464
7.
Oral ciclopirox olamine displays biological activity in a phase I study in patients with advanced hematologic malignancies.
Am J Hematol
; 89(4): 363-8, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24273151
8.
Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia.
Signal Transduct Target Ther
; 7(1): 51, 2022 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35185150
9.
The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability.
Sci Transl Med
; 12(538)2020 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32269163
10.
Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal.
Cell Stem Cell
; 26(6): 926-937.e10, 2020 06 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32416059
11.
De Novo Design of Boron-Based Peptidomimetics as Potent Inhibitors of Human ClpP in the Presence of Human ClpX.
J Med Chem
; 62(13): 6377-6390, 2019 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31187989
12.
Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.
Cancer Cell
; 35(5): 721-737.e9, 2019 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31056398
13.
The Mitochondrial Transacylase, Tafazzin, Regulates for AML Stemness by Modulating Intracellular Levels of Phospholipids.
Cell Stem Cell
; 24(4): 621-636.e16, 2019 04 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30930145
14.
Correction: Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia.
Signal Transduct Target Ther
; 7(1): 110, 2022 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35365596
15.
A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia.
Cancer Med
; 5(11): 3031-3040, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27734609
16.
Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.
Cancer Cell
; 27(6): 864-76, 2015 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26058080
17.
A novel formulation of tigecycline has enhanced stability and sustained antibacterial and antileukemic activity.
PLoS One
; 9(5): e95281, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24871339
18.
A porphodimethene chemical inhibitor of uroporphyrinogen decarboxylase.
PLoS One
; 9(2): e89889, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24587102
19.
The Mitochondrial Transacylase, Tafazzin, Regulates AML Stemness by Modulating Intracellular Levels of Phospholipids.
Cell Stem Cell
; 24(6): 1007, 2019 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31173706
20.
Mapping the cellular response to small molecules using chemogenomic fitness signatures.
Science
; 344(6180): 208-11, 2014 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24723613