Detalhe da pesquisa
1.
Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy.
J Struct Biol
; 176(3): 292-301, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21963792
2.
Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide].
J Pharmacol Exp Ther
; 331(3): 816-26, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19741151
3.
Repair of topoisomerase I-mediated DNA damage.
Prog Nucleic Acid Res Mol Biol
; 81: 179-229, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16891172
4.
X-ray structures of checkpoint kinase 2 in complex with inhibitors that target its gatekeeper-dependent hydrophobic pocket.
FEBS Lett
; 585(20): 3245-9, 2011 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-21907711
5.
Effect of phenazine compounds XR11576 and XR5944 on DNA topoisomerases.
Cancer Chemother Pharmacol
; 63(5): 889-901, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18679685
6.
Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor.
Protein Sci
; 18(1): 92-100, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19177354
7.
Detection of in vitro kinase generated protein phosphorylation sites using gamma[18O4]-ATP and mass spectrometry.
Anal Chem
; 79(20): 7603-10, 2007 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17877366
8.
Identification of a Bis-guanylhydrazone [4,4'-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase.
Mol Pharmacol
; 72(4): 876-84, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17616632