Detalhe da pesquisa
1.
Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes.
Proc Natl Acad Sci U S A
; 118(52)2021 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34949639
2.
Apabetalone and hospitalization for heart failure in patients following an acute coronary syndrome: a prespecified analysis of the BETonMACE study.
Cardiovasc Diabetol
; 20(1): 13, 2021 01 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33413345
3.
Relation of insulin treatment for type 2 diabetes to the risk of major adverse cardiovascular events after acute coronary syndrome: an analysis of the BETonMACE randomized clinical trial.
Cardiovasc Diabetol
; 20(1): 125, 2021 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34158057
4.
ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes.
J Neurosci
; 39(48): 9611-9622, 2019 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31641056
5.
Effect of Apabetalone Added to Standard Therapy on Major Adverse Cardiovascular Events in Patients With Recent Acute Coronary Syndrome and Type 2 Diabetes: A Randomized Clinical Trial.
JAMA
; 323(16): 1565-1573, 2020 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32219359
6.
Effect of selective BET protein inhibitor apabetalone on cardiovascular outcomes in patients with acute coronary syndrome and diabetes: Rationale, design, and baseline characteristics of the BETonMACE trial.
Am Heart J
; 217: 72-83, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31520897
7.
Apolipoprotein E derived HDL mimetic peptide ATI-5261 promotes nascent HDL formation and reverse cholesterol transport in vitro.
Biochim Biophys Acta
; 1842(10): 1498-512, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25091998
8.
Epigenetic BET reader inhibitor apabetalone (RVX-208) counters proinflammatory aortic gene expression in a diet induced obesity mouse model and in human endothelial cells.
Atherosclerosis
; 364: 10-19, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36455344
9.
Apabetalone Downregulates Fibrotic, Inflammatory and Calcific Processes in Renal Mesangial Cells and Patients with Renal Impairment.
Biomedicines
; 11(6)2023 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37371758
10.
Dual mechanism: Epigenetic inhibitor apabetalone reduces SARS-CoV-2 Delta and Omicron variant spike binding and attenuates SARS-CoV-2 RNA induced inflammation.
Int Immunopharmacol
; 117: 109929, 2023 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-36857935
11.
A novel apoE-mimetic increases brain apoE levels, reduces Aß pathology and improves memory when treated before onset of pathology in male mice that express APOE3.
Alzheimers Res Ther
; 15(1): 216, 2023 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38102668
12.
The BET inhibitor apabetalone decreases neuroendothelial proinflammatory activation in vitro and in a mouse model of systemic inflammation.
Transl Neurosci
; 14(1): 20220332, 2023 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38222824
13.
Breaking boundaries: Pan BETi disrupt 3D chromatin structure, BD2-selective BETi are strictly epigenetic transcriptional regulators.
Biomed Pharmacother
; 152: 113230, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-35687908
14.
Effect of the ABCA1 agonist CS-6253 on amyloid-ß and lipoprotein metabolism in cynomolgus monkeys.
Alzheimers Res Ther
; 14(1): 87, 2022 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35751102
15.
Inhibition of epigenetic reader proteins by apabetalone counters inflammation in activated innate immune cells from Fabry disease patients receiving enzyme replacement therapy.
Pharmacol Res Perspect
; 10(3): e00949, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35417091
16.
Reduction in the risk of major adverse cardiovascular events with the BET protein inhibitor apabetalone in patients with recent acute coronary syndrome, type 2 diabetes, and moderate to high likelihood of non-alcoholic fatty liver disease.
Am J Prev Cardiol
; 11: 100372, 2022 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-36039183
17.
Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro.
Biomedicines
; 9(4)2021 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33919584
18.
Effect of Apabetalone on Cardiovascular Events in Diabetes, CKD, and Recent Acute Coronary Syndrome: Results from the BETonMACE Randomized Controlled Trial.
Clin J Am Soc Nephrol
; 16(5): 705-716, 2021 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33906908
19.
Cognitive Effects of the BET Protein Inhibitor Apabetalone: A Prespecified Montreal Cognitive Assessment Analysis Nested in the BETonMACE Randomized Controlled Trial.
J Alzheimers Dis
; 83(4): 1703-1715, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34459400
20.
Epigenetic Modulation by Apabetalone Counters Cytokine-Driven Acute Phase Response In Vitro, in Mice and in Patients with Cardiovascular Disease.
Cardiovasc Ther
; 2020: 9397109, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32821285