Detalhe da pesquisa
1.
Validation of Plasmodium falciparum dUTPase as the target of 5'-tritylated deoxyuridine analogues with anti-malarial activity.
Malar J
; 18(1): 392, 2019 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31796083
2.
Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase.
Bioorg Med Chem
; 21(18): 5876-85, 2013 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23916149
3.
Discovery of 4'-azido-2'-deoxy-2'-C-methyl cytidine and prodrugs thereof: a potent inhibitor of Hepatitis C virus replication.
Bioorg Med Chem Lett
; 22(9): 3265-8, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22472694
4.
ß-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase.
Bioorg Med Chem
; 19(7): 2378-91, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21411327
5.
Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease.
J Med Chem
; 63(6): 3066-3089, 2020 03 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32134269
6.
Profound antiviral effect of oral administration of MIV-210 on chronic hepadnaviral infection in a woodchuck model of hepatitis B.
Antimicrob Agents Chemother
; 53(9): 3803-14, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19564357
7.
Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni.
J Enzyme Inhib Med Chem
; 24(1): 111-6, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18608754
8.
Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors.
Antimicrob Agents Chemother
; 52(8): 2861-9, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18541726
9.
dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors.
Structure
; 13(2): 329-38, 2005 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-15698576
10.
Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase.
J Med Chem
; 49(14): 4183-95, 2006 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-16821778
11.
Modified 5'-trityl nucleosides as inhibitors of Plasmodium falciparum dUTPase.
ChemMedChem
; 6(2): 309-20, 2011 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21246738
12.
Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
ChemMedChem
; 6(10): 1816-31, 2011 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-22049550
13.
Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase.
Eur J Med Chem
; 44(2): 678-88, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18619713
14.
The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4'-azidocytidine against hepatitis C virus replication: the discovery of 4'-azido-2'-deoxy-2'-fluorocytidine and 4'-azido-2'-dideoxy-2',2'-difluorocytidine.
J Med Chem
; 52(9): 2971-8, 2009 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19341305
15.
The design, synthesis, and antiviral activity of 4'-azidocytidine analogues against hepatitis C virus replication: the discovery of 4'-azidoarabinocytidine.
J Med Chem
; 52(1): 219-23, 2009 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-19055482
16.
2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups.
J Biol Chem
; 283(4): 2167-75, 2008 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-18003608