Detalhe da pesquisa
1.
Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity.
Bioorg Med Chem
; 23(16): 5156-67, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25678015
2.
Allosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralog.
J Biol Chem
; 288(21): 15256-67, 2013 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-23525104
3.
Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome.
Mol Microbiol
; 86(1): 51-64, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22857512
4.
Trypanosoma brucei UDP-glucose:glycoprotein glucosyltransferase has unusual substrate specificity and protects the parasite from stress.
Eukaryot Cell
; 8(2): 230-40, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19114500
5.
Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome.
PLoS Negl Trop Dis
; 9(12): e0004299, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26684831
6.
Synthesis and evaluation of indatraline-based inhibitors for trypanothione reductase.
ChemMedChem
; 6(2): 321-8, 2011 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21275055
7.
Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein crystallography.
J Med Chem
; 54(19): 6514-30, 2011 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21851087
8.
Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis.
Biochem Pharmacol
; 80(10): 1478-86, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20696141
9.
Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi.
Mol Biochem Parasitol
; 169(1): 12-9, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19747949
10.
Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis.
ChemMedChem
; 4(8): 1333-40, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19557801
11.
Development of a novel virtual screening cascade protocol to identify potential trypanothione reductase inhibitors.
J Med Chem
; 52(6): 1670-80, 2009 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-19296695
12.
Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase.
ChemMedChem
; 4(8): 1341-53, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19557802
13.
High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity.
Bioorg Med Chem Lett
; 17(5): 1280-3, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17197182
14.
Deletion of the glucosidase II gene in Trypanosoma brucei reveals novel N-glycosylation mechanisms in the biosynthesis of variant surface glycoprotein.
J Biol Chem
; 280(43): 35929-42, 2005 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-16120601