Detalhe da pesquisa
1.
Assessment of pharmacokinetic interaction between rilotumumab and epirubicin, cisplatin and capecitabine (ECX) in a Phase 3 study in gastric cancer.
Br J Clin Pharmacol
; 83(5): 1048-1055, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27966237
2.
Validation of 4ß-hydroxycholesterol and evaluation of other endogenous biomarkers for the assessment of CYP3A activity in healthy subjects.
Br J Clin Pharmacol
; 78(5): 1122-34, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24837659
3.
Simultaneous oral therapeutic and intravenous ¹4C-microdoses to determine the absolute oral bioavailability of saxagliptin and dapagliflozin.
Br J Clin Pharmacol
; 75(3): 763-8, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22823746
4.
The influence of kidney function on dapagliflozin exposure, metabolism and pharmacodynamics in healthy subjects and in patients with type 2 diabetes mellitus.
Br J Clin Pharmacol
; 76(3): 432-44, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23210765
5.
Use of low-dose clinical pharmacodynamic and pharmacokinetic data to establish an occupational exposure limit for dapagliflozin, a potent inhibitor of the renal sodium glucose co-transporter 2.
Regul Toxicol Pharmacol
; 67(1): 89-97, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23851069
6.
Best Practices and Considerations for Clinical Pharmacology and Pharmacometric Aspects for Optimal Development of CAR-T and TCR-T Cell Therapies: An Industry Perspective.
Clin Pharmacol Ther
; 114(3): 530-557, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37393588
7.
Evolution of preclinical characterization and insights into clinical pharmacology of checkpoint inhibitors approved for cancer immunotherapy.
Clin Transl Sci
; 15(8): 1818-1837, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35588531
8.
Quantification of 4-beta-hydroxycholesterol in human plasma using automated sample preparation and LC-ESI-MS/MS analysis.
Chem Res Toxicol
; 24(9): 1575-85, 2011 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21728364
9.
A Population Pharmacokinetic Meta-Analysis of Veliparib, a PARP Inhibitor, Across Phase 1/2/3 Trials in Cancer Patients.
J Clin Pharmacol
; 61(9): 1195-1205, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33894017
10.
Phase I Open-Label Study Evaluating the Safety, Pharmacokinetics, and Preliminary Efficacy of Dilpacimab in Patients with Advanced Solid Tumors.
Mol Cancer Ther
; 20(10): 1988-1995, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34315767
11.
Model Informed Dosing Regimen and Phase I Results of the Anti-PD-1 Antibody Budigalimab (ABBV-181).
Clin Transl Sci
; 14(1): 277-287, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32770720
12.
Informing Development of Bispecific Antibodies Using Physiologically Based Pharmacokinetic-Pharmacodynamic Models: Current Capabilities and Future Opportunities.
J Clin Pharmacol
; 60 Suppl 1: S132-S146, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33205425
13.
Influence of Renal Function on Evolocumab Exposure, Pharmacodynamics, and Safety.
Clin Pharmacol Drug Dev
; 8(3): 281-289, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30676701
14.
Pharmacokinetics of gabapentin after a single day and at steady state following the administration of gastric-retentive- extended-release and immediate-release tablets: a randomized, open-label, multiple-dose, three-way crossover, exploratory study in healthy subjects.
Clin Ther
; 30(5): 909-16, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18555937
15.
Reverse Translation: The Art of Cyclical Learning.
Clin Pharmacol Ther
; 103(2): 152-159, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29313963
16.
How Well Are We Applying Quantitative Methods to Reverse Translation to Inform Early Clinical Development?
Clin Pharmacol Ther
; 103(2): 174-176, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29274086
17.
Bedside to Bench: Integrating Quantitative Clinical Pharmacology and Reverse Translation to Optimize Drug Development.
Clin Pharmacol Ther
; 103(2): 196-198, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29105747
18.
Clinical Pharmacokinetics and Pharmacodynamics of Evolocumab, a PCSK9 Inhibitor.
Clin Pharmacokinet
; 57(7): 769-779, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29353350
19.
Crowdsourced Asparagus Urinary Odor Population Kinetics.
CPT Pharmacometrics Syst Pharmacol
; 7(1): 34-41, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29239147
20.
In vitro permeation of repellent DEET and sunscreen oxybenzone across three artificial membranes.
Int J Pharm
; 310(1-2): 110-7, 2006 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-16414221