[Effect of ronkoleukin on nitric oxide and lipid peroxidation indices in hepatocarcinogenesis].

Hepatocarcinogenesis induced by DENA lead to increase in NO2 level, decrease in L-Arginin and Malonic Di-aldehyde (MDA) levels. The use of doksorubicyn slightly increases L-Arginin level in blood serum in mice without affecting considerably nitrite levels. Doksorubicin application in combination with ronkoleukin enables profound consumption of L-Arginin, increases nitrite levels and MDA. It is likely connected with increased formation of peroxynitrite which negatively affects tumor cells.

[Morphological features of the thymus in heliotrin hepatitis upon administration of immunostimulators]. / Morfologicheskie osobennosti timusa pri geliotrinnom gepatite v usloviiakh vvedeniia immunostimuliatorov.

Structural changes of thymus in heliotrin hepatitis were characterized by distinct dynamics which on the whole suggested the progressing hypoplasia of its cortex. Immunostimulants parandin and thymalin suppressed the extent of thymocyte destruction and stimulated their mitotic activity. Although these parameters did not reach the control levels, the significant deceleration of hypoplastic processes in thymus, particularly in its cortex, were detected. Effect of immunostimulants was independent on the time of their administration in respect to heliotrin injection.