Detalhe da pesquisa
1.
Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer.
Nature
; 578(7794): 306-310, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31969702
2.
Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors.
Bioorg Med Chem Lett
; 28(10): 1804-1810, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29678460
3.
Methylpyrrole inhibitors of BET bromodomains.
Bioorg Med Chem Lett
; 27(10): 2225-2233, 2017 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28268136
4.
Discovery of fluorobenzimidazole HCV NS5A inhibitors.
Bioorg Med Chem Lett
; 26(22): 5462-5467, 2016 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27780635
5.
Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif.
Bioorg Med Chem Lett
; 23(12): 3487-90, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23664214
6.
Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo.
J Med Chem
; 66(6): 3852-3865, 2023 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36877935
7.
Identification of aryl dihydrouracil derivatives as palm initiation site inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett
; 22(11): 3747-50, 2012 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22542020
8.
Antiviral Drug Discovery for the Treatment of COVID-19 Infections.
Viruses
; 14(5)2022 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35632703
9.
Co-clinical Modeling of the Activity of the BET Inhibitor Mivebresib (ABBV-075) in AML.
In Vivo
; 36(4): 1615-1627, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35738590
10.
Hepatitis C NS5B polymerase inhibitors: functional equivalents for the benzothiadiazine moiety.
Bioorg Med Chem Lett
; 21(6): 1876-9, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21316235
11.
Biomarkers for the clinical development of antiviral therapies.
Cytometry B Clin Cytom
; 100(1): 19-32, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34542933
12.
Selective Inhibition of the Second Bromodomain of BET Family Proteins Results in Robust Antitumor Activity in Preclinical Models of Acute Myeloid Leukemia.
Mol Cancer Ther
; 20(10): 1809-1819, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34253595
13.
Discovery of N-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain.
J Med Chem
; 63(10): 5585-5623, 2020 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32324999
14.
Synthesis of potent pyrrolidine influenza neuraminidase inhibitors.
Bioorg Med Chem Lett
; 18(5): 1692-5, 2008 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18242993
15.
Synthesis, antiviral activity, and conformational studies of a P3 aza-peptide analog of a potent macrocyclic tripeptide HCV protease inhibitor.
Bioorg Med Chem Lett
; 18(8): 2745-50, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18375121
16.
Synthesis and SAR of novel 1,1-dialkyl-2(1H)-naphthalenones as potent HCV polymerase inhibitors.
Bioorg Med Chem Lett
; 18(2): 568-70, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18068361
17.
Identification of halosalicylamide derivatives as a novel class of allosteric inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett
; 18(11): 3173-7, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18479921
18.
Hepatitis C NS5B polymerase inhibitors: 4,4-Dialkyl-1-hydroxy-3-oxo-3,4-dihydronaphthalene-3-yl benzothiadiazine derivatives.
Bioorg Med Chem Lett
; 18(14): 3887-90, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18599294
19.
Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability.
J Med Chem
; 61(3): 1153-1163, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29342358
20.
Highlights of the Structure-Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530).
J Med Chem
; 61(9): 4052-4066, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29653491