RESUMO
This nationwide study assessed the antimicrobial susceptibility and seroprevalence of Streptococcus pneumoniae in paediatric carriage isolates and in clinical isolates from adult pneumococcal disease in Greece during the years 2004-2006. Among 780 isolates recovered from the nasopharynx of children <6 years old attending day-care centres, non-susceptibility rates to penicillin, cefuroxime, ceftriaxone, erythromycin, tetracycline and trimethoprim/sulfamethoxazole were 34.7%, 25.1%, 1.0%, 33.5%, 26.4% and 44.2%, respectively. Among 89 adult clinical isolates, the respective rates were 48.3%, 46.1%, 5.6%, 48.3%, 32.6% and 40.4%. High-level resistance to penicillin, cefuroxime and ceftriaxone was recorded for 14.4%, 23.3% and 0.1% of paediatric carriage isolates, whereas for clinical adult isolates the respective rates were 25.8%, 38.2% and 2.2%. No resistance to levofloxacin and moxifloxacin was recorded, although 3.5% of paediatric carriage isolates and 23.2% of adult clinical isolates had minimum inhibitory concentrations of ciprofloxacin >2mg/L. Serotypes 19F, 14, 23F and 6B were the most prevalent among carriage and clinical isolates. The 7-valent pneumococcal conjugate vaccine was estimated to provide coverage against 71.7% of paediatric carriage isolates and 51.3% of adult clinical isolates. Resistance rates among clinical isolates from adult sources were higher than those recorded among paediatric carriage S. pneumoniae isolates and displayed an increasingly resistant profile compared with previous reports from our country, warranting continuous vigilance.
Assuntos
Farmacorresistência Bacteriana , Infecções Pneumocócicas/microbiologia , Streptococcus pneumoniae/classificação , Streptococcus pneumoniae/efeitos dos fármacos , Adolescente , Adulto , Idoso , Antibacterianos/farmacologia , Portador Sadio/microbiologia , Criança , Pré-Escolar , Feminino , Grécia/epidemiologia , Vacina Pneumocócica Conjugada Heptavalente , Humanos , Lactente , Masculino , Vacinas Meningocócicas/imunologia , Testes de Sensibilidade Microbiana , Pessoa de Meia-Idade , Nasofaringe/microbiologia , Infecções Pneumocócicas/epidemiologia , Vacinas Pneumocócicas/imunologia , Prevalência , Sorotipagem , Streptococcus pneumoniae/isolamento & purificaçãoRESUMO
Campylobacter jejuni is a common cause of gastroenteritis especially in childhood. However, extraintestinal manifestations of C. jejuni such as bacteremia, cholecystitis, pancreatitis and osteomyelitis are rare. Meningitis in newborns caused by this organism is unusually rare. We report a case of neonatal meningitis in a 15-day old term boy caused by Campylobacter jejuni.
Assuntos
Infecções por Campylobacter/diagnóstico , Campylobacter jejuni , Meningites Bacterianas/diagnóstico , Humanos , Lactente , Masculino , Punção EspinalRESUMO
After a brief account of anthrax morbidity in northern Greece in recent years, 4 cases in 1977 of cutaneous anthrax in 10 to 13-year-old children are presented. Two had an atypical cutaneous lesion. In 1 of these, a 13-year-old girl, the disease was complicated by severe, eventually fatal meningitis. Death ensued despite intensive treatment with high doses of penicillin and hydrocortisone. This case is the first report of anthrax meningitis in a child in Greece and the third reported in the last 15 years. We stress the diagnostic difficulties in atypical cases of cutaneous anthrax and the need for early diagnosis and treatment to avoid spread of infection and appearance of complications such as the usually fatal meningitis.