Detalhe da pesquisa
1.
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorg Med Chem Lett
; 91: 129352, 2023 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37270074
2.
Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase.
Bioorg Med Chem Lett
; 39: 127904, 2021 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33684441
3.
Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
Bioorg Med Chem Lett
; 30(22): 127523, 2020 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32877741
4.
Identification of a novel series of azabenzimidazole-derived inhibitors of spleen tyrosine kinase.
Bioorg Med Chem Lett
; 30(18): 127393, 2020 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32721854
5.
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Bioorg Med Chem Lett
; 30(19): 127433, 2020 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32717371
6.
Identification of azabenzimidazoles as potent JAK1 selective inhibitors.
Bioorg Med Chem Lett
; 26(1): 60-7, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26614408
7.
Sulfonylpiperidines as novel, antibacterial inhibitors of Gram-positive thymidylate kinase (TMK).
Bioorg Med Chem Lett
; 23(1): 169-73, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23206863
8.
Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction.
J Med Chem
; 66(12): 8310-8323, 2023 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37307526
9.
Inhibitors of acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 1: Hit to lead evaluation of a novel arylsulfonamide series.
Bioorg Med Chem Lett
; 22(4): 1510-9, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22297115
10.
Virtual fragment screening: exploration of MM-PBSA re-scoring.
J Comput Aided Mol Des
; 26(8): 921-34, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22869295
11.
Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase.
J Med Chem
; 64(23): 17146-17183, 2021 12 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34807608
12.
EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex.
Cell Chem Biol
; 27(1): 41-46.e17, 2020 01 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31786184
13.
Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor.
J Med Chem
; 63(9): 4517-4527, 2020 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32297743
14.
Virtual fragment screening: an exploration of various docking and scoring protocols for fragments using Glide.
J Comput Aided Mol Des
; 23(8): 527-39, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19495993
15.
Rapid Identification of Novel Allosteric PRC2 Inhibitors.
ACS Chem Biol
; 14(10): 2134-2140, 2019 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31525019
16.
Stereoselective glycosylations of 2-azido-2-deoxy-glucosides using intermediate sulfonium ions.
Org Lett
; 9(10): 1959-62, 2007 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-17432867
17.
Cycloaromatization of 1,4-pentadiynes: a viable possibility?
Org Lett
; 4(21): 3643-6, 2002 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-12375908
18.
Antibacterial inhibitors of Gram-positive thymidylate kinase: structure-activity relationships and chiral preference of a new hydrophobic binding region.
J Med Chem
; 57(11): 4584-97, 2014 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24828090
19.
In vivo validation of thymidylate kinase (TMK) with a rationally designed, selective antibacterial compound.
ACS Chem Biol
; 7(11): 1866-72, 2012 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22908966
20.
Discovery of selective and potent inhibitors of gram-positive bacterial thymidylate kinase (TMK).
J Med Chem
; 55(22): 10010-21, 2012 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-23043329