Detalhe da pesquisa
1.
Biochemical characterization of tirabrutinib and other irreversible inhibitors of Bruton's tyrosine kinase reveals differences in on - and off - target inhibition.
Biochim Biophys Acta Gen Subj
; 1864(4): 129531, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31953125
2.
Discovery of an Atropisomeric PI3Kß Selective Inhibitor through Optimization of the Hinge Binding Motif.
ACS Med Chem Lett
; 11(6): 1236-1243, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32551006
3.
AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
Cancer Discov
; 8(12): 1582-1597, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30254093
4.
PI3Kδ inhibitor idelalisib in combination with BTK inhibitor ONO/GS-4059 in diffuse large B cell lymphoma with acquired resistance to PI3Kδ and BTK inhibitors.
PLoS One
; 12(2): e0171221, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28178345
5.
Discovery of a Phosphoinositide 3-Kinase (PI3K) ß/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kß Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856.
J Med Chem
; 60(4): 1555-1567, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28106991
6.
Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors.
Eur J Med Chem
; 80: 364-82, 2014 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24793884
7.
Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor for treating acute myeloid leukemia.
Mol Cancer Ther
; 13(4): 880-9, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24526162
8.
Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
J Med Chem
; 57(8): 3430-49, 2014 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24641103