Detalhe da pesquisa
1.
Determination of label efficiency and label degree of critical reagents by LC-MS and native MS.
Anal Biochem
; 664: 115033, 2023 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36584741
2.
Antibody Subunit LC-MS Analysis for Pharmacokinetic and Biotransformation Determination from In-Life Studies for Complex Biotherapeutics.
Anal Chem
; 92(12): 8268-8277, 2020 06 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32392410
3.
Mapping intact protein isoforms in discovery mode using top-down proteomics.
Nature
; 480(7376): 254-8, 2011 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-22037311
4.
Protein LC-MS Tools for the Next Generation of Biotherapeutic Analyses from Preclinical and Clinical Serum.
J Am Soc Mass Spectrom
; 34(9): 1837-1846, 2023 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37478497
5.
Top-Down Characterization and Intact Mass Quantitation of a Monoclonal Antibody Drug from Serum by Use of a Quadrupole TOF MS System Equipped with Electron-Activated Dissociation.
J Am Soc Mass Spectrom
; 34(1): 17-26, 2023 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36459688
6.
2022 White Paper on Recent Issues in Bioanalysis: ICH M10 BMV Guideline & Global Harmonization; Hybrid Assays; Oligonucleotides & ADC; Non-Liquid & Rare Matrices; Regulatory Inputs (Part 1A - Recommendations on Mass Spectrometry, Chromatography and Sample Preparation, Novel Technologies, Novel Modalities, and Novel Challenges, ICH M10 BMV Guideline & Global Harmonization Part 1B - Regulatory Agencies' Inputs on Regulated Bioanalysis/BMV, Biomarkers/CDx/BAV, Immunogenicity, Gene & Cell Therapy and Vaccine).
Bioanalysis
; 15(16): 955-1016, 2023 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-37650500
7.
Nano-LC FTICR tandem mass spectrometry for top-down proteomics: routine baseline unit mass resolution of whole cell lysate proteins up to 72 kDa.
Anal Chem
; 84(5): 2111-7, 2012 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22356091
8.
Robust analysis of the yeast proteome under 50 kDa by molecular-mass-based fractionation and top-down mass spectrometry.
Anal Chem
; 84(1): 209-15, 2012 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22103811
9.
An antibody-free platform for multiplexed, sensitive quantification of protein biomarkers in complex biomatrices.
J Chromatogr A
; 1676: 463261, 2022 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35752151
10.
2021 White Paper on Recent Issues in Bioanalysis: Mass Spec of Proteins, Extracellular Vesicles, CRISPR, Chiral Assays, Oligos; Nanomedicines Bioanalysis; ICH M10 Section 7.1; Non-Liquid & Rare Matrices; Regulatory Inputs (Part 1A - Recommendations on Endogenous Compounds, Small Molecules, Complex Methods, Regulated Mass Spec of Large Molecules, Small Molecule, PoC & Part 1B - Regulatory Agencies' Inputs on Bioanalysis, Biomarkers, Immunogenicity, Gene & Cell Therapy and Vaccine).
Bioanalysis
; 14(9): 505-580, 2022 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-35578993
11.
Intact Protein Mass Spectrometry for Therapeutic Protein Quantitation, Pharmacokinetics, and Biotransformation in Preclinical and Clinical Studies: An Industry Perspective.
J Am Soc Mass Spectrom
; 32(8): 1886-1900, 2021 Aug 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32869982
12.
Cloud solutions for GxP laboratories: considerations for data storage.
Bioanalysis
; 13(17): 1313-1321, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-34515519
13.
Intact mass detection, interpretation, and visualization to automate Top-Down proteomics on a large scale.
Proteomics
; 10(20): 3589-97, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20848673
14.
Size-sorting combined with improved nanocapillary liquid chromatography-mass spectrometry for identification of intact proteins up to 80 kDa.
Anal Chem
; 82(4): 1234-44, 2010 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20073486
15.
IQ consortium perspective: complementary LBA and LC-MS in protein therapeutics bioanalysis and biotransformation assessment.
Bioanalysis
; 12(4): 257-270, 2020 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-32096432
16.
Intact mAb LC-MS for drug concentration from pre-clinical studies: bioanalytical method performance and in-life samples.
Bioanalysis
; 12(19): 1389-1403, 2020 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-32975433
17.
Biotherapeutic Antibody Subunit LC-MS and Peptide Mapping LC-MS Measurements to Study Possible Biotransformation and Critical Quality Attributes In Vivo.
J Pharm Sci
; 108(4): 1415-1422, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30465782
18.
2019 White Paper on Recent Issues in Bioanalysis: Chromatographic Assays (Part 1 - Innovation in Small Molecules and Oligonucleotides & Mass Spectrometric Method Development Strategies for Large Molecule Bioanalysis).
Bioanalysis
; 11(22): 2029-2048, 2019 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-31808716
19.
Review of approaches and examples for monitoring biotransformation in protein and peptide therapeutics by MS.
Bioanalysis
; 10(22): 1877-1890, 2018 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30325207
20.
Drug monitoring by volumetric absorptive microsampling: method development considerations to mitigate hematocrit effects.
Bioanalysis
; 10(4): 241-255, 2018 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-29333871