Pesquisa | Biblioteca Virtual em Saúde

1.

Structural elements of an NRPS cyclization domain and its intermodule docking domain.

Dowling, Daniel P; Kung, Yan; Croft, Anna K; Taghizadeh, Koli; Kelly, Wendy L; Walsh, Christopher T; Drennan, Catherine L.

Proc Natl Acad Sci U S A ; 113(44): 12432-12437, 2016 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-27791103

2.

Biosynthesis of the Thiopeptins and Identification of an F₄₂₀H₂-Dependent Dehydropiperidine Reductase.

Ichikawa, Hiro; Bashiri, Ghader; Kelly, Wendy L.

J Am Chem Soc ; 140(34): 10749-10756, 2018 08 29.

Artigo em Inglês | MEDLINE | ID: mdl-30118217

3.

Spectroscopic and Electrochemical Characterization of the Iron-Sulfur and Cobalamin Cofactors of TsrM, an Unusual Radical S-Adenosylmethionine Methylase.

Blaszczyk, Anthony J; Silakov, Alexey; Zhang, Bo; Maiocco, Stephanie J; Lanz, Nicholas D; Kelly, Wendy L; Elliott, Sean J; Krebs, Carsten; Booker, Squire J.

J Am Chem Soc ; 138(10): 3416-26, 2016 Mar 16.

Artigo em Inglês | MEDLINE | ID: mdl-26841310

4.

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.

Arnison, Paul G; Bibb, Mervyn J; Bierbaum, Gabriele; Bowers, Albert A; Bugni, Tim S; Bulaj, Grzegorz; Camarero, Julio A; Campopiano, Dominic J; Challis, Gregory L; Clardy, Jon; Cotter, Paul D; Craik, David J; Dawson, Michael; Dittmann, Elke; Donadio, Stefano; Dorrestein, Pieter C; Entian, Karl-Dieter; Fischbach, Michael A; Garavelli, John S; Göransson, Ulf; Gruber, Christian W; Haft, Daniel H; Hemscheidt, Thomas K; Hertweck, Christian; Hill, Colin; Horswill, Alexander R; Jaspars, Marcel; Kelly, Wendy L; Klinman, Judith P; Kuipers, Oscar P; Link, A James; Liu, Wen; Marahiel, Mohamed A; Mitchell, Douglas A; Moll, Gert N; Moore, Bradley S; Müller, Rolf; Nair, Satish K; Nes, Ingolf F; Norris, Gillian E; Olivera, Baldomero M; Onaka, Hiroyasu; Patchett, Mark L; Piel, Joern; Reaney, Martin J T; Rebuffat, Sylvie; Ross, R Paul; Sahl, Hans-Georg; Schmidt, Eric W; Selsted, Michael E.

Nat Prod Rep ; 30(1): 108-60, 2013 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-23165928

5.

Biochemistry: life imitates art.

Kelly, Wendy L.

Nature ; 473(7345): 35-6, 2011 May 05.

Artigo em Inglês | MEDLINE | ID: mdl-21544137

6.

Recent advances in thiopeptide antibiotic biosynthesis.

Li, Chaoxuan; Kelly, Wendy L.

Nat Prod Rep ; 27(2): 153-64, 2010 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-20111801

7.

Intermittent Parathyroid Hormone Accelerates Stress Fracture Healing More Effectively Following Cessation of Bisphosphonate Treatment.

Bakr, Mahmoud M; Kelly, Wendy L; Brunt, Athena R; Paterson, Bradley C; Massa, Helen M; Morrison, Nigel A; Forwood, Mark R.

JBMR Plus ; 4(9): e10387, 2020 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-32995690

8.

Thiostrepton biosynthesis: prototype for a new family of bacteriocins.

Kelly, Wendy L; Pan, Lisa; Li, Chaoxuan.

J Am Chem Soc ; 131(12): 4327-34, 2009 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-19265401

9.

Analysis of the indanomycin biosynthetic gene cluster from Streptomyces antibioticus NRRL 8167.

Li, Chaoxuan; Roege, Kathryn E; Kelly, Wendy L.

Chembiochem ; 10(6): 1064-72, 2009 Apr 17.

Artigo em Inglês | MEDLINE | ID: mdl-19301315

10.

Biosynthesis: Ringing in a new view.

Kelly, Wendy L.

Nat Chem Biol ; 8(6): 505-7, 2012 May 17.

Artigo em Inglês | MEDLINE | ID: mdl-22596200

11.

Single injection of PTH improves osteoclastic parameters of remodeling at a stress fracture site in rats.

Bakr, Mahmoud M; Kelly, Wendy L; Brunt, Athena R; Paterson, Bradley C; Massa, Helen M; Morrison, Nigel A; Forwood, Mark R.

J Orthop Res ; 37(5): 1172-1182, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-30816593

12.

Intramolecular cyclizations of polyketide biosynthesis: mining for a "Diels-Alderase"?

Kelly, Wendy L.

Org Biomol Chem ; 6(24): 4483-93, 2008 Dec 21.

Artigo em Inglês | MEDLINE | ID: mdl-19039353

13.

Inhibitors of cyclo-oxygenase-2 and secretory phospholipase A2 preserve bone architecture following ovariectomy in adult rats.

Gregory, Laura S; Kelly, Wendy L; Reid, Robert C; Fairlie, David P; Forwood, Mark R.

Bone ; 39(1): 134-42, 2006 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-16473054

14.

Thiostrepton Variants Containing a Contracted Quinaldic Acid Macrocycle Result from Mutagenesis of the Second Residue.

Zhang, Feifei; Li, Chaoxuan; Kelly, Wendy L.

ACS Chem Biol ; 11(2): 415-24, 2016 Feb 19.

Artigo em Inglês | MEDLINE | ID: mdl-26630475

15.

Saturation mutagenesis of TsrA Ala4 unveils a highly mutable residue of thiostrepton A.

Zhang, Feifei; Kelly, Wendy L.

ACS Chem Biol ; 10(4): 998-1009, 2015 Apr 17.

Artigo em Inglês | MEDLINE | ID: mdl-25572285

16.

Osteocyte expression of caspase-3, COX-2, IL-6 and sclerostin are spatially and temporally associated following stress fracture initiation.

Wu, Andy C; Kidd, Lisa J; Cowling, Nicholas R; Kelly, Wendy L; Forwood, Mark R.

Bonekey Rep ; 3: 571, 2014.

Artigo em Inglês | MEDLINE | ID: mdl-25228984

17.

Selective and non-selective cyclooxygenase inhibitors delay stress fracture healing in the rat ulna.

Kidd, Lisa J; Cowling, Nick R; Wu, Andy C; Kelly, Wendy L; Forwood, Mark R.

J Orthop Res ; 31(2): 235-42, 2013 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-22847634

18.

In vivo production of thiopeptide variants.

Zhang, Feifei; Kelly, Wendy L.

Methods Enzymol ; 516: 3-24, 2012.

Artigo em Inglês | MEDLINE | ID: mdl-23034221

19.

Mutagenesis of the thiostrepton precursor peptide at Thr7 impacts both biosynthesis and function.

Li, Chaoxuan; Zhang, Feifei; Kelly, Wendy L.

Chem Commun (Camb) ; 48(4): 558-60, 2012 Jan 14.

Artigo em Inglês | MEDLINE | ID: mdl-22068975

20.

Heterologous production of thiostrepton A and biosynthetic engineering of thiostrepton analogs.

Li, Chaoxuan; Zhang, Feifei; Kelly, Wendy L.

Mol Biosyst ; 7(1): 82-90, 2011 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-21107477

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Structural elements of an NRPS cyclization domain and its intermodule docking domain.

Biosynthesis of the Thiopeptins and Identification of an F₄₂₀H₂-Dependent Dehydropiperidine Reductase.

Spectroscopic and Electrochemical Characterization of the Iron-Sulfur and Cobalamin Cofactors of TsrM, an Unusual Radical S-Adenosylmethionine Methylase.

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.

Biochemistry: life imitates art.

Recent advances in thiopeptide antibiotic biosynthesis.

Intermittent Parathyroid Hormone Accelerates Stress Fracture Healing More Effectively Following Cessation of Bisphosphonate Treatment.

Thiostrepton biosynthesis: prototype for a new family of bacteriocins.

Analysis of the indanomycin biosynthetic gene cluster from Streptomyces antibioticus NRRL 8167.

Biosynthesis: Ringing in a new view.

Single injection of PTH improves osteoclastic parameters of remodeling at a stress fracture site in rats.

Intramolecular cyclizations of polyketide biosynthesis: mining for a "Diels-Alderase"?

Inhibitors of cyclo-oxygenase-2 and secretory phospholipase A2 preserve bone architecture following ovariectomy in adult rats.

Thiostrepton Variants Containing a Contracted Quinaldic Acid Macrocycle Result from Mutagenesis of the Second Residue.

Saturation mutagenesis of TsrA Ala4 unveils a highly mutable residue of thiostrepton A.

Osteocyte expression of caspase-3, COX-2, IL-6 and sclerostin are spatially and temporally associated following stress fracture initiation.

Selective and non-selective cyclooxygenase inhibitors delay stress fracture healing in the rat ulna.

In vivo production of thiopeptide variants.

Mutagenesis of the thiostrepton precursor peptide at Thr7 impacts both biosynthesis and function.

Heterologous production of thiostrepton A and biosynthetic engineering of thiostrepton analogs.