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Am J Clin Hypn ; 53(1): 27-46, 2010 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-20718241

RESUMO

In a 2008 pilot study we used DNA microarrays to explore the historical ideo-plastic faculty of therapeutic hypnosis. We documented how to measure changes in activity or experience-dependent gene expression over relatively brief time periods (1 hour and 24 hours) following a single intervention of therapeutic hypnosis (about 1 hour). In the present paper we utilize bioinformatic software to explore the possible meaning and significance of this ideo-plastic faculty of therapeutic hypnosis. Indications suggest that the ideo-plastic process of therapeutic hypnosis may be associated with (1) the heightening of a molecular-genomic signature for the up-regulation (heightened activity) of genes characteristic of stem cell growth, (2) a reduction in cellular oxidative stress, and (3) a reduction in chronic inflammation. We identify these three empirical associations as an initial beta version of the molecular-genomic signature of the ideo-plastic process of therapeutic hypnosis, which can serve as a theoretical and practical guide for clinical excellence by beginners as well as senior professionals. We propose this molecular-genomic level of discourse as a supplement to the traditional cognitive-behavioral description of therapeutic suggestion, hypnosis, and psychotherapy that is consistent with "translational research" currently funded by the National Institute of Mental Health (NIMH).


Assuntos
Biologia Computacional , Regulação da Expressão Gênica/genética , Hipnose/métodos , Análise de Sequência com Séries de Oligonucleotídeos/métodos , Software , Encéfalo/metabolismo , Terapia Cognitivo-Comportamental , Perfilação da Expressão Gênica , Pesquisa em Genética , Humanos , Inflamação/genética , Plasticidade Neuronal/genética , Estresse Oxidativo , Células-Tronco/fisiologia , Pesquisa Translacional Biomédica , Regulação para Cima/genética
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