Detalhe da pesquisa
1.
Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors.
Bioorg Med Chem Lett
; 90: 129331, 2023 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37187252
2.
Thioridazine reverts the phenotype in cellular and Drosophila models of amyotrophic lateral sclerosis by enhancing TDP-43 aggregate clearance.
Neurobiol Dis
; 160: 105515, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34571136
3.
Patient-derived explants (PDEs) as a powerful preclinical platform for anti-cancer drug and biomarker discovery.
Br J Cancer
; 122(6): 735-744, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31894140
4.
Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty.
Bioorg Med Chem Lett
; 29(19): 126610, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31471167
5.
Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines.
Bioorg Med Chem Lett
; 29(3): 509-514, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30553738
6.
Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG).
Bioorg Med Chem Lett
; 28(19): 3168-3173, 2018 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30174152
7.
Structure of a Potential Therapeutic Antibody Bound to Interleukin-16 (IL-16): MECHANISTIC INSIGHTS AND NEW THERAPEUTIC OPPORTUNITIES.
J Biol Chem
; 291(32): 16840-8, 2016 08 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27231345
8.
Terbinafine is a novel and selective activator of the two-pore domain potassium channel TASK3.
Biochem Biophys Res Commun
; 493(1): 444-450, 2017 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28882594
9.
The effect of TG2-inhibitory monoclonal antibody zampilimab on tissue fibrosis in human in vitro and primate in vivo models of chronic kidney disease.
PLoS One
; 19(5): e0298864, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38753630
10.
Cloxyquin (5-chloroquinolin-8-ol) is an activator of the two-pore domain potassium channel TRESK.
Biochem Biophys Res Commun
; 441(2): 463-8, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24383077
11.
A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novel activator of the p53 pathway.
Bioorg Med Chem Lett
; 23(20): 5578-85, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24007918
12.
Transglutaminase 2: Development of therapeutic antibodies reveals four inhibitory epitopes and confirms extracellular function in fibrotic remodelling.
Br J Pharmacol
; 179(11): 2697-2712, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34879432
13.
Fragment-based target screening as an empirical approach to prioritising targets: a case study on antibacterials.
Drug Discov Today
; 2020 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32920060
14.
Design of the LifeArc Index Set and Retrospective Review of Its Performance: A Collection for Sharing.
SLAS Discov
; 24(3): 332-345, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30290126
15.
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.
Nat Commun
; 8(1): 430, 2017 09 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28874661
16.
A High-Throughput Electrophysiology Assay Identifies Inhibitors of the Inwardly Rectifying Potassium Channel Kir7.1.
J Biomol Screen
; 20(6): 739-47, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25656238
17.
Are academic drug discovery efforts receiving more recognition with declining industry efficiency?
Expert Opin Drug Discov
; 14(7): 605-607, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30907161
18.
The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy.
EMBO Mol Med
; 6(9): 1161-74, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25056913
19.
Identification of small-molecule inhibitors of the ribonuclease H2 enzyme.
J Biomol Screen
; 18(5): 610-20, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23427046
20.
Screening ß-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors.
J Biomol Screen
; 18(5): 599-609, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23396314