Detalhe da pesquisa
1.
Identification and targeting of a unique NaV1.7 domain driving chronic pain.
Proc Natl Acad Sci U S A
; 120(32): e2217800120, 2023 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37498871
2.
A peptidomimetic modulator of the CaV2.2 N-type calcium channel for chronic pain.
Proc Natl Acad Sci U S A
; 120(47): e2305215120, 2023 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37972067
3.
Human Hsp70 Substrate-Binding Domains Recognize Distinct Client Proteins.
Biochemistry
; 63(3): 251-263, 2024 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38243804
4.
Discovery and characterization of small molecules that target the GTPase Ral.
Nature
; 515(7527): 443-7, 2014 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25219851
5.
Hierarchical CRMP2 posttranslational modifications control NaV1.7 function.
Proc Natl Acad Sci U S A
; 113(52): E8443-E8452, 2016 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27940916
6.
Structural basis for 2'-phosphate incorporation into glycogen by glycogen synthase.
Proc Natl Acad Sci U S A
; 110(52): 20976-81, 2013 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24324135
7.
Mapping CRMP3 domains involved in dendrite morphogenesis and voltage-gated calcium channel regulation.
J Cell Sci
; 126(Pt 18): 4262-73, 2013 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23868973
8.
Expression and purification of functional human glycogen synthase-1 (hGYS1) in insect cells.
Protein Expr Purif
; 90(2): 78-83, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23711380
9.
Small-molecule inhibition of the uPAR·uPA interaction: synthesis, biochemical, cellular, in vivo pharmacokinetics and efficacy studies in breast cancer metastasis.
Bioorg Med Chem
; 21(7): 2145-55, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23411397
10.
Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases.
J Biol Chem
; 286(50): 43486-94, 2011 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22021038
11.
CRMP-2 peptide mediated decrease of high and low voltage-activated calcium channels, attenuation of nociceptor excitability, and anti-nociception in a model of AIDS therapy-induced painful peripheral neuropathy.
Mol Pain
; 8: 54, 2012 Jul 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-22828369
12.
Design, synthesis, biochemical studies, cellular characterization, and structure-based computational studies of small molecules targeting the urokinase receptor.
Bioorg Med Chem
; 20(15): 4760-73, 2012 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22771232
13.
Generation of an iPSC line from a Pontocerebellar Hypoplasia 1B patient harboring a homozygous c.395 A > C mutation in EXOSC3 along with a family matched control.
Stem Cell Res
; 65: 102944, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36257093
14.
Aptamers Targeting Hallmark Proteins of Neurodegeneration.
Nucleic Acid Ther
; 32(4): 235-250, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35452303
15.
Animal Models of Neurodegenerative Disease: Recent Advances in Fly Highlight Innovative Approaches to Drug Discovery.
Front Mol Neurosci
; 15: 883358, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35514431
16.
Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology.
Sci Rep
; 12(1): 8140, 2022 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35581326
17.
A systematic characterization of Cwc21, the yeast ortholog of the human spliceosomal protein SRm300.
RNA
; 15(12): 2174-85, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19789211
18.
Target-specific support vector machine scoring in structure-based virtual screening: computational validation, in vitro testing in kinases, and effects on lung cancer cell proliferation.
J Chem Inf Model
; 51(4): 755-9, 2011 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21438548
19.
Direct targeting of TDP-43, from small molecules to biologics: the therapeutic landscape.
RSC Chem Biol
; 2(4): 1158-1166, 2021 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34458829
20.
In Silico Targeting of the Long Noncoding RNA MALAT1.
ACS Med Chem Lett
; 12(6): 915-921, 2021 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34141069