Detalhe da pesquisa
1.
RX-5902, a novel ß-catenin modulator, potentiates the efficacy of immune checkpoint inhibitors in preclinical models of triple-negative breast Cancer.
BMC Cancer
; 20(1): 1063, 2020 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33148223
2.
Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease.
Proc Natl Acad Sci U S A
; 112(28): 8756-61, 2015 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26124091
3.
Lipid-Albumin Nanoparticles (LAN) for Therapeutic Delivery of Antisense Oligonucleotide against HIF-1α.
Mol Pharm
; 13(7): 2555-62, 2016 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27253378
4.
A Novel Anti-Cancer Agent, 1-(3,5-Dimethoxyphenyl)-4-[(6-Fluoro-2-Methoxyquinoxalin-3-yl)Aminocarbonyl] Piperazine (RX-5902), Interferes With ß-Catenin Function Through Y593 Phospho-p68 RNA Helicase.
J Cell Biochem
; 116(8): 1595-601, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25649741
5.
Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360).
Invest New Drugs
; 31(6): 1444-57, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24048768
6.
Norepinephrine deficiency is caused by combined abnormal mRNA processing and defective protein trafficking of dopamine beta-hydroxylase.
J Biol Chem
; 286(11): 9196-204, 2011 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-21209083
7.
Synthesis, anticancer activity and pharmacokinetic analysis of 1-[(substituted 2-alkoxyquinoxalin-3-yl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives.
Bioorg Med Chem
; 20(3): 1303-9, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22226981
8.
Antitumor activity of a novel antisense oligonucleotide against Akt1.
J Cell Biochem
; 108(4): 832-8, 2009 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19693774
9.
First-in-Class Phosphorylated-p68 Inhibitor RX-5902 Inhibits ß-Catenin Signaling and Demonstrates Antitumor Activity in Triple-Negative Breast Cancer.
Mol Cancer Ther
; 18(11): 1916-1925, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31488700
10.
Folate receptor-targeted lipid-albumin nanoparticles (F-LAN) for therapeutic delivery of an Akt1 antisense oligonucleotide.
J Drug Target
; 26(5-6): 466-473, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29376449
11.
A novel cytidine analog, RX-3117, shows potent efficacy in xenograft models, even in tumors that are resistant to gemcitabine.
Anticancer Res
; 34(12): 6951-9, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25503121
12.
Clavulanic acid inhibits MPPâº-induced ROS generation and subsequent loss of dopaminergic cells.
Brain Res
; 1469: 129-35, 2012 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22750587
13.
Polymeric LabChip real-time PCR as a point-of-care-potential diagnostic tool for rapid detection of influenza A/H1N1 virus in human clinical specimens.
PLoS One
; 7(12): e53325, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23285281
14.
Clavulanic acid increases dopamine release in neuronal cells through a mechanism involving enhanced vesicle trafficking.
Neurosci Lett
; 504(2): 170-175, 2011 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-21964384
15.
Clavulanic acid stimulates sexual behaviour in male rats.
Eur J Pharmacol
; 609(1-3): 69-73, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19285063