Detalhe da pesquisa
1.
Discovery and bio-optimization of human antibody therapeutics using the XenoMouse® transgenic mouse platform.
Immunol Rev
; 270(1): 51-64, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26864104
2.
Antibody-mediated neutralization of autocrine Gas6 inhibits the growth of pancreatic ductal adenocarcinoma tumors in vivo.
Int J Cancer
; 139(6): 1340-9, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27170265
3.
The high-resolution crystal structure of human LCAT.
J Lipid Res
; 56(9): 1711-9, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26195816
4.
Anti-PCSK9 antibody pharmacokinetics and low-density lipoprotein-cholesterol pharmacodynamics in nonhuman primates are antigen affinity-dependent and exhibit limited sensitivity to neonatal Fc receptor-binding enhancement.
J Pharmacol Exp Ther
; 353(1): 119-31, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25653417
5.
A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates.
Blood
; 122(17): 3054-61, 2013 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-23945155
6.
A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates.
Proc Natl Acad Sci U S A
; 106(24): 9820-5, 2009 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-19443683
7.
Molecular Insight into Recognition of the CGRPR Complex by Migraine Prevention Therapy Aimovig (Erenumab).
Cell Rep
; 30(6): 1714-1723.e6, 2020 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32049005
8.
Rapid single B cell antibody discovery using nanopens and structured light.
MAbs
; 11(6): 1025-1035, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31185801
9.
Discovery of the Migraine Prevention Therapeutic Aimovig (Erenumab), the First FDA-Approved Antibody against a G-Protein-Coupled Receptor.
ACS Pharmacol Transl Sci
; 2(6): 485-490, 2019 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32259079
10.
Flow Cytometry-Based Epitope Binning Using Competitive Binding Profiles for the Characterization of Monoclonal Antibodies against Cellular and Soluble Protein Targets.
SLAS Discov
; 23(7): 613-623, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29783865
11.
High-throughput screening of hybridoma supernatants using multiplexed fluorescent cell barcoding on live cells.
J Immunol Methods
; 451: 20-27, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28803843
12.
Therapeutic Antibody Targeting Tumor- and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to Chemotherapy.
Cancer Cell
; 32(6): 731-747.e6, 2017 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29232552
13.
Evaluation of recombinant monoclonal antibody SVmab1 binding to Na V1.7 target sequences and block of human Na V1.7 currents.
F1000Res
; 5: 2764, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27990272
14.
Development and characterization of a human antibody reference panel against erythropoietin suitable for the standardization of ESA immunogenicity testing.
J Immunol Methods
; 382(1-2): 129-41, 2012 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-22634015
15.
Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT.
Cell Metab
; 15(6): 905-17, 2012 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22682226
16.
Treating diabetes and obesity with an FGF21-mimetic antibody activating the ßKlotho/FGFR1c receptor complex.
Sci Transl Med
; 4(162): 162ra153, 2012 Nov 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23197570