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1.
Skeletal Radiol ; 53(4): 597-608, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-37828095

RESUMO

This article reviews the diagnosis and treatment of flexor tendon injuries of the hand highlighting flexor tendon anatomy, important pre-operative imaging findings, surgical options, and post-operative complications. Imaging plays a key role in guiding treatment of these difficult to manage injuries. Thus, it is important for radiologists to have a sound understanding of factors important in treatment decision-making. In the pre-operative setting, accurately identifying the location of the torn proximal tendon stump in subacute and chronic injuries helps dictate whether the patient is a candidate for a primary flexor tendon repair or may require a tendon reconstruction to restore function. In the post-operative setting, the status of the repair and presence of surrounding adhesions help dictate if and when the patient will require subsequent surgery and whether that surgery will be a tenolysis, revision repair, reconstruction, or fusion.


Assuntos
Traumatismos dos Dedos , Traumatismos da Mão , Traumatismos dos Tendões , Humanos , Tendões/diagnóstico por imagem , Tendões/cirurgia , Traumatismos dos Tendões/diagnóstico por imagem , Traumatismos dos Tendões/cirurgia , Mãos/diagnóstico por imagem , Mãos/cirurgia , Traumatismos da Mão/diagnóstico por imagem , Traumatismos da Mão/cirurgia , Radiologistas , Traumatismos dos Dedos/diagnóstico por imagem , Traumatismos dos Dedos/cirurgia
2.
Calcif Tissue Int ; 112(6): 716-726, 2023 06.
Artigo em Inglês | MEDLINE | ID: mdl-37093268

RESUMO

Cannabidiol (CBD), the non-psychoactive component of the Cannabis sativa plant, is marketed as a potential therapeutic agent and has been studied for its roles in reducing inflammation and managing neuropathic pain. Some studies have reported that CB1 and CB2 receptor activation can attenuate and reverse bone loss in experimental animal models. Despite this, little is known about the impact of CBD on fracture healing. We investigated the effects of CBD in vitro using human osteoprogenitor cells and in vivo via murine femur fracture and osteoporosis models. In vitro mesenchymal stem cells were treated with increasing concentrations of crystalized pharmaceutical grade CBD or vehicle solution. Cell viability and proliferation were significantly increased in cells treated with CBD compared to vehicle control. Osteocalcin expression was also significantly higher in the CBD-treated human stem cells compared to vehicle control. In vivo the effect of CBD on bone mineral density and fracture healing in mice was examined using a two-phase experimental approach. Fluoxetine was used for pharmacologic induction of osteoporosis and surgical oophorectomy (OVX) was used for hormonal induction of osteoporosis. X-ray and microCT analysis showed that CBD prevented both fluoxetine- and OVX-induced osteoporosis. We found that while OVX resulted in delayed bone healing in control mice, CBD-pretreated mice exhibited normal bone healing. Collectively these in vitro and in vivo findings suggest that CBD exerts cell-specific effects which can be exploited to enhance bone metabolism. These findings also indicate that CBD usage in an osteoporotic population may positively impact bone morphology, warranting further research.


Assuntos
Canabidiol , Células-Tronco Mesenquimais , Osteoporose , Humanos , Camundongos , Animais , Canabidiol/farmacologia , Canabidiol/metabolismo , Canabidiol/uso terapêutico , Sobrevivência Celular , Fluoxetina/metabolismo , Fluoxetina/farmacologia , Osteoporose/tratamento farmacológico , Osteoporose/prevenção & controle , Osteoporose/metabolismo , Modelos Animais , Expressão Gênica , Proliferação de Células
3.
Knee Surg Sports Traumatol Arthrosc ; 30(7): 2419-2423, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34738159

RESUMO

PURPOSE: The purpose of this study was to determine and establish the MCID for the NAHS at 2 years in patients undergoing hip arthroscopy for femoroacetabular impingement syndrome (FAIS). METHODS: Patients that underwent primary hip arthroscopy for FAIS between 2010 and 2016 were analyzed for eligibility. Data were collected from a single surgeon's hip arthroscopy database. MCID was calculated for the NAHS utilizing a distribution-based method. RESULTS: The study included 298 patients (184 females) with an average age of 40.4 ± 13.0 years and average body mass index (BMI) of 25.7 ± 4.2 kg/m2. At baseline, the cohort's average NAHS score was 48.7 ± 13.6 and demonstrated an improvement of 36.5 ± 17.0 for NAHS at follow-up. This resulted in MCID values of + 8.5 for NAHS. CONCLUSION: This is the first study to report the MCID (+ 8.5) for NAHS following primary hip arthroscopy, and as such, is a valuable contribution to future hip arthroscopy research. LEVEL OF EVIDENCE: IV.


Assuntos
Impacto Femoroacetabular , Diferença Mínima Clinicamente Importante , Atividades Cotidianas , Adulto , Artroscopia/métodos , Feminino , Impacto Femoroacetabular/diagnóstico , Impacto Femoroacetabular/cirurgia , Seguimentos , Articulação do Quadril/cirurgia , Humanos , Pessoa de Meia-Idade , Medidas de Resultados Relatados pelo Paciente , Estudos Retrospectivos , Resultado do Tratamento
4.
J Hand Surg Am ; 2022 Aug 03.
Artigo em Inglês | MEDLINE | ID: mdl-35933254

RESUMO

PURPOSE: Autologous bone grafts demonstrate osteoconductive, osteoinductive, and osteogenic properties. Hand surgeons commonly augment surgical fixation with autografts to promote fracture healing. This study compared the intrinsic stem cell-like properties of 2 commonly used autograft sources in hand surgery: the iliac crest and distal radius. METHODS: A total of 9 subjects who received an iliac crest bone graft and distal radius bone graft harvest as a part of the standard care of distal radius malunion or nonunion correction or scaphoid nonunion open reduction and internal fixation were enrolled in the study. Cells were isolated by serial collagenase digestion and subjected to fibroblast colony-forming units, osteogenesis, and adipogenesis assays. The expression levels of genes involved in osteogenesis and adipogenesis were confirmed using quantitative polymerase chain reaction. RESULTS: The cells isolated from the iliac crest bone graft compared with those isolated from the distal radius bone graft demonstrated significantly higher mean fibroblast colony-forming unit efficiency; increased osteogenesis, as measured using alizarin red quantification; increased adipogenesis, as measured using oil red O quantification; and higher expression levels of genes involved in osteogenesis and adipogenesis under the respective differentiation conditions. CONCLUSIONS: The cells isolated from the iliac crest bone graft demonstrated a higher fibroblast colony-forming unit capacity and an increased capability to undergo both osteogenesis and adipogenesis. CLINICAL RELEVANCE: Limited evidence exists comparing the intrinsic stem cell-like properties of the iliac crest and distal radius despite the widespread use of each source in hand and wrist surgery. The information from this investigation may assist hand and wrist surgeons with the selection of a source of autograft.

5.
Arthroscopy ; 37(2): 530-536, 2021 02.
Artigo em Inglês | MEDLINE | ID: mdl-33045334

RESUMO

PURPOSE: To determine whether postoperative acetaminophen reduced narcotic consumption following hip arthroscopy for femoroacetabular impingement. METHODS: This was a single-center randomized controlled trial. Opioid-naïve patients undergoing hip arthroscopy for femoroacetabular impingement were randomized into 2 groups. The control group received our institution's standard of care for postoperative pain control, 28 tablets of 5 mg/325 mg oxycodone-acetaminophen prescribed as 1 to 2 tablets every 6 hours as needed for pain, whereas the treatment group were prescribed 650 mg acetaminophen every 6 hours for pain, with 5 mg/325 mg oxycodone-acetaminophen prescribed for breakthrough pain. Patients were instructed to be mindful of taking no more than 3 g of acetaminophen in a 24-hour limit. If this limit was reached, oxycodone 5 mg would be prescribed. They were contacted daily and asked to report opioid use as well as their level of pain using the visual analog pain scale. RESULTS: Our institution enrolled 86 patients, 80 of whom completed the study (40 control, 40 treatment). There were no statistically significant differences with respect to patient demographics and patient-specific factors between groups (age at time of surgery, sex, American Society of Anesthesiologists classification, or body mass index). In addition, there was no statistically significant difference with respect to visual analog scale pain between groups preoperatively (P = .64) or at 1-week follow up (P = .39). The treatment group did not use a statistically significant different number of narcotics than the control group throughout the first postoperative week (6.325 pills treatment vs 5.688 pills control, P = .237). CONCLUSIONS: The findings of this randomized controlled trial suggest that postoperative acetaminophen may have no effect on reducing the number of narcotic pills consumed by opioid-naïve patients following hip arthroscopy in the setting of reduced opioid-prescribing on the part of orthopaedic surgeons. Furthermore, the results of this study suggest surgeons may reduce postoperative narcotic prescribing without reducing patient satisfaction following hip arthroscopy. LEVEL OF EVIDENCE: II randomized control trial.


Assuntos
Acetaminofen/uso terapêutico , Artroscopia , Quadril/cirurgia , Oxicodona/uso terapêutico , Dor Pós-Operatória/tratamento farmacológico , Adulto , Analgésicos Opioides/uso terapêutico , Feminino , Impacto Femoroacetabular/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Medição da Dor , Satisfação do Paciente , Estudos Prospectivos
6.
J Hand Surg Am ; 46(12): 1088-1093, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34474948

RESUMO

PURPOSE: Corticosteroid injections (CSIs) are commonly used in carpal tunnel syndrome; however, recent literature has demonstrated risk of postoperative infection associated with preoperative CSIs in other orthopedic fields. The aim of this study was to assess the relationship of CSIs and postoperative infection following carpal tunnel release (CTR). METHODS: A single-center retrospective review was conducted from 2010 to 2019 to identify patients who underwent CTR with subsequent antibiotic prescription for chart-documented wound infection. A demographically-matched cohort of 100 patients was identified for comparison. Information on patient demographics, comorbidities, injection history, and presence of postoperative infection was collected. RESULTS: Thirty-nine patients (0.67% of all CTR patients) were identified with postoperative infections, 3 of which (0.05% of all CTR patients) were deep infections. In the infection cohort, 16 of 39 (41%) patients received an injection prior to surgery, whereas 16 of 100 (16%) patients in the control cohort received an injection. History of CSI was significantly more common in patients with postoperative infection, and patients in the infection cohort had a significantly shorter average time from injection to surgery by approximately 55 days. CONCLUSIONS: Corticosteroid injections in the preoperative period are associated with postoperative infection after CTR. Proximity of injection to time of surgery plays a role, although comorbidities, the corticosteroid dose, and frequency of injection require further study to determine risk contribution. TYPE OF STUDY/LEVEL OF EVIDENCE: Prognostic III.


Assuntos
Síndrome do Túnel Carpal , Corticosteroides/uso terapêutico , Síndrome do Túnel Carpal/tratamento farmacológico , Síndrome do Túnel Carpal/cirurgia , Humanos , Injeções , Complicações Pós-Operatórias/epidemiologia , Estudos Retrospectivos
7.
J Arthroplasty ; 36(1): 286-290.e1, 2021 01.
Artigo em Inglês | MEDLINE | ID: mdl-32919848

RESUMO

BACKGROUND: Vancomycin powder and dilute povidone-iodine lavage (VIP) was introduced to reduce the incidence of periprosthetic joint infection (PJI) in high-risk total knee arthroplasty (TKA) patients. We hypothesize that VIP can reduce the incidence of early PJI in all primary TKA patients, regardless of preoperative risk. METHODS: An infection database of primary TKAs performed before a VIP protocol was implemented (January 2012-December 2013), during a time when only high-risk TKAs received VIP (January 2014-December 2015), and when all TKAs received VIP (January 2016-September 2019) at an urban, university-affiliated, not-for-profit orthopedic hospital was retrospectively reviewed to identify patients with PJI. Criteria used for diagnosis of PJI were the National Healthcare Safety Network and Musculoskeletal Infection Society guidelines. RESULTS: VIP reduced early primary TKA PJI incidence in both the high-risk and all-risk cohorts compared with the pre-VIP cohort by 44.6% and 56.4%, respectively (1.01% vs 0.56% vs 0.44%, P = .0088). In addition, after introducing VIP to all-risk TKA patients, compared with high-risk TKA patients, the relative risk of PJI dropped an additional 21.4%, but this finding did not reach statistical significance (0.56% vs 0.44%, P = .4212). There were no demographic differences between the 3 VIP PJI cohorts. CONCLUSION: VIP is associated with a reduced early PJI incidence after primary TKA, regardless of preoperative risk. With the literature supporting its safety and cost-effectiveness, VIP is a value-based intervention, but given the nature of this historical cohort study, a multicenter randomized controlled trial is underway to definitively confirm its efficacy.


Assuntos
Artroplastia do Joelho , Povidona-Iodo/uso terapêutico , Infecções Relacionadas à Prótese , Vancomicina/uso terapêutico , Artroplastia do Joelho/efeitos adversos , Humanos , Pós , Infecções Relacionadas à Prótese/epidemiologia , Infecções Relacionadas à Prótese/prevenção & controle , Estudos Retrospectivos , Irrigação Terapêutica
8.
J Arthroplasty ; 36(7S): S314-S319, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-33526397

RESUMO

BACKGROUND: While vancomycin powder and dilute povidone-iodine (VIP) is associated with fewer total joint arthroplasty (TJA) periprosthetic joint infections (PJI), its effect on PJI organism profiles is unclear. This study evaluates primary TJA PJI organism profiles before and after the implementation of a VIP protocol. METHODS: In total, 18,299 primary TJAs performed at a university-affiliated, not-for-profit orthopedic hospital from before (1/2012-12/2013) and after (1/2016-12/2019) a VIP protocol was initiated were reviewed to identify deep PJIs that occurred within 90 days of the index arthroplasty as defined by the Musculoskeletal Infection Society guidelines. Demographics, overall organism incidence (n/TJAs), and relative organism incidence (n/PJIs) from the two cohorts were compared. RESULTS: In total, 103 TJA PJIs were identified (pre-VIP: 32/3982; VIP: 71/14,317). Following the introduction of VIP, the overall and relative incidence of coagulase-negative staphylococcal TJA PJIs significantly decreased (overall: 0.20% to 0.04%, P = .004; relative: 25.00% to 8.45%, P = .031). In response, the relative incidence of MSSA TJA PJIs significantly increased (18.75% to 40.85%, P = .042). Broken down by arthroplasty type, VIP was associated with a significantly lower overall incidence of coagulase-negative staphylococcal total knee arthroplasty (TKA) PJIs (0.27% to 0.06%, P = .015), a significantly lower overall incidence of MRSA TKA PJIs (0.18% to 0.03%, P = .031), and a nonsignificant decrease in the overall incidence of gram-negative TKA PJIs (0.18% to 0.04%, P = .059). No organism profile changes were found in total hip arthroplasty PJIs. CONCLUSION: VIP is not associated with more difficult to treat primary TJA PJIs. While promising, these findings require a prospective randomized controlled trial for confirmation. LEVEL OF EVIDENCE: Level III, Retrospective cohort study.


Assuntos
Artroplastia de Quadril , Infecções Relacionadas à Prótese , Artroplastia de Quadril/efeitos adversos , Humanos , Povidona-Iodo , Pós , Infecções Relacionadas à Prótese/epidemiologia , Infecções Relacionadas à Prótese/prevenção & controle , Estudos Retrospectivos , Irrigação Terapêutica , Vancomicina
9.
Telemed J E Health ; 27(10): 1151-1159, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-33512302

RESUMO

Background:Owing to the COVID-19 pandemic, there has been a large shift in health care toward virtual platforms. This study analyzed patient and physician satisfaction with telehealth during the height of the pandemic within the division of sports medicine.Methods:All sports medicine patients who completed a telemedicine visit from March 30, 2020, through April 30, 2020, were sent a 14-question Likert scale (1-5/5) survey. Sports medicine physicians who used telemedicine were sent a separate 14-question Likert scale (1-5/5) survey at the end of the study period. Factors influencing patient satisfaction were determined using a multivariate linear regression model.Results:A total of 143 patients and 9 sports medicine attendings completed the surveys. Most patients were "satisfied" (4/5) or "very satisfied" (5/5) (88.8%). A multivariate linear regression determined that patients who believed they had a greater ability to adopt new technology and were more effective at communicating questions/concerns to their physicians had greater satisfaction (p = 0.009 and p = 0.015, respectively). Most physicians were either "satisfied" (4/5) or "very satisfied" (5/5) (75.0%). On average, physicians felt that physical examinations conducted through telemedicine were "moderately effective" (2.75/5.00 ± 1.3), that they were "fairly confident" (3.86/5.00 ± 0.83) in their diagnoses, and that most sports medicine attendings plan to use telemedicine in the future (87.5%).Conclusion:Telehealth emerged as a valuable tool for the delivery of health care to sports medicine patients during the COVID-19 pandemic. Patients and physicians reported high levels of satisfactions with its use, and this study further identifies areas that can improve the patient and physician experience.


Assuntos
COVID-19 , Médicos , Medicina Esportiva , Telemedicina , Humanos , Pandemias , Satisfação do Paciente , Satisfação Pessoal , SARS-CoV-2
10.
Arthroscopy ; 36(11): 2849-2855, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-32721548

RESUMO

PURPOSE: To evaluate clinical outcomes in patients who underwent endoscopic gluteus medius repair with at least 2-year follow-up. METHODS: This was a single-center, single-surgeon retrospective study of 19 patients (20 hips) who underwent endoscopic knotless gluteus medius repair between August 2010 and August 2016 with ≥2 years of follow-up. Preoperative magnetic resonance imaging (MRI) was reviewed and graded according to the Goutallier/Fuchs classification; preoperative X-rays were reviewed and graded according to the Tonnis classification. Baseline and 2-year postoperative modified Harris hip score (mHHS) and nonarthritic hip score (NAHS) were prospectively collected. The numbers of patients reaching the minimal clinically important difference (MCID) and patient acceptable symptomatic rate (PASS) were determined. RESULTS: Twenty hips from 19 patients met the inclusion criteria and were separated based on tear type. The study population comprised 15 (79%) females and 4 (21%) males presenting with a mean age of 51.3 ± 11.9 years and an average body mass index of 25.3 ± 3.9 kg/m2. Patients with partial tears reported average preoperative mHHS and NAHS of 33.6 ± 11.3 and 40.4 ± 14.9, respectively; at 2-year follow-up, average mHHS and NAHS of 72.9 ± 22.9 and 77.2 ± 19.7 were reported. Patients with full-thickness tears reported average preoperative mHHS and NAHS of 43.8 ± 14.7 and 46.4 ± 8.3, respectively; at 2-year follow-up, average mHHS and NAHS of 80.1 ± 8.5 and 79.5 ± 10.1 were reported. There was significant clinical improvement at 2-year follow-up, relating to both outcome measures in each subject group (P < .001). At 2 years, 90% of hips surpassed MCID, and 63% of hips achieved PASS. CONCLUSION: Endoscopic repair for gluteus medius tears results in improved mHHS and NAHS at 2 years of follow-up compared with baseline. Most patients reach critical thresholds of minimal and satisfactory clinical improvement. LEVEL OF EVIDENCE: Level IV, case series with subgroup analysis.


Assuntos
Nádegas/cirurgia , Endoscopia/métodos , Traumatismos dos Tendões/cirurgia , Tendões/cirurgia , Adulto , Artroscopia/métodos , Feminino , Seguimentos , Quadril/cirurgia , Articulação do Quadril/cirurgia , Humanos , Lacerações , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Diferença Mínima Clinicamente Importante , Músculo Esquelético/cirurgia , Satisfação do Paciente , Período Pós-Operatório , Estudos Retrospectivos , Resultado do Tratamento
11.
Ann Plast Surg ; 84(4): 463-470, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-31688112

RESUMO

BACKGROUND: The reverse sural artery flap (RSAF) is a popular option for patients with distal lower extremity defects who are not ideal candidates for free flap reconstruction. This is the first systematic review and pooled analysis of surgical characteristics, risk factors, and outcomes of the RSAF. METHODS: A systematic literature review was conducted. All studies reporting on patients undergoing RSAF reconstruction and their outcomes were included. Outcomes were pooled and analyzed using Fisher exact or χ test. RESULTS: Forty-three studies (479 patients, 481 flaps) were analyzed. The majority of patients were male (70.3%), and average ± SD age was 46.9 ± 16.7 years. Rates of smoking, diabetes mellitus (DM), and peripheral vascular disease (PVD) were 34.6%, 35.4%, and 12.3%, respectively. Defect etiologies were largely traumatic (60.4%). The most common defect location was the heel (40.8%). Flap modifications were reported in 123 flaps (25.6%). The most common modification was adipofascial extension (20.3%).Overall, the partial and total flap loss rates were 15.4% and 3.1%, respectively. Partial flap loss was significantly increased in smokers (28.9% vs 12.2% in nonsmokers, P = 0.0195). Technical modifications decreased the odds of partial necrosis by almost 3-fold compared with traditional RSAF reconstruction (7.2% vs 17.9%; odds ratio, 2.8 [1.4-5.8]; P = 0.0035). Patient age, DM, and PVD were not significantly associated with flap loss. CONCLUSIONS: The RSAF remains a safe salvage option for patients with DM or PVD but should be used with caution in smokers. Technical modifications to minimize pedicle compression significantly reduce rates of partial necrosis.


Assuntos
Procedimentos de Cirurgia Plástica , Lesões dos Tecidos Moles , Adulto , Artérias , Feminino , Humanos , Extremidade Inferior/cirurgia , Masculino , Pessoa de Meia-Idade , Medição de Risco , Lesões dos Tecidos Moles/etiologia , Lesões dos Tecidos Moles/cirurgia , Retalhos Cirúrgicos
12.
J Pediatr Orthop ; 38(8): e455-e461, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-29889773

RESUMO

BACKGROUND: We studied the prevalence and treatment outcomes of spondylolisthesis in patients with Loeys-Dietz syndrome (LDS). METHODS: Clinical data and lumbosacral imaging of 138 patients with LDS were reviewed. Spondylolisthesis (L4-L5 or L5-S1) and spondylolysis were characterized by multimodal imaging and correlated with clinical data. Treatments and outcomes were characterized for patients with spondylolisthesis. Associations were determined using the Fisher exact, Mann-Whitney, and Student t tests (α=0.05). RESULTS: Twenty-four patients (17%) had spondylolysis and 23 (17%) had spondylolisthesis. Median age at spondylolisthesis diagnosis was 11 (interquartile range, 9.5) years. In patients in whom measurement was possible (n=20), mean (±SD) slip was 48% (±35%). Nineteen patients had L5-S1 slip and 4 had L4-L5 slip. Of the patients with spondylolisthesis, 5 had no evidence of spondylolysis; of those with spondylolysis, all but 6 had spondylolisthesis. Eleven patients with spondylolisthesis underwent posterior spinal fusion (PSF) to treat slip progression, pain, and/or neurological deficit. Spondylolisthesis recurred in 1 patient who underwent PSF with bone graft arthrodesis alone (no instrumentation). The other 10 patients underwent PSF with instrumentation and fusion. Three patients additionally underwent Bohlman interbody fusion. Two patients developed implant failure. S2 fixation was performed at revision to achieve fusion in these patients. Mean Meyerding grade improved in patients who underwent arthrodesis, from 3.9 (±1.2) to 1.9 (±1.3) (P=0.002). Complications were 2 cerebrospinal fluid leaks, 2 transient postoperative paresthesias, and 1 case each of pseudarthrosis at S1-S2, wound dehiscence, and transient urinary incontinence. No significant associations between LDS type and lumbosacral abnormalities were found. CONCLUSIONS: High-grade spondylolisthesis is common in LDS and usually associated with spondylolysis. Patients requiring surgery for spondylolisthesis present during childhood and do well after instrumented PSF. Interbody fusion and stabilization of S1 and S2 can prevent physeal deformation. LDS should be considered in patients with high-grade spondylolisthesis. Patients with LDS should be monitored for spondylolisthesis and spondylolysis starting when they are young. LEVEL OF EVIDENCE: Level IV-retrospective study.


Assuntos
Síndrome de Loeys-Dietz/complicações , Vértebras Lombares/diagnóstico por imagem , Sacro/diagnóstico por imagem , Fusão Vertebral/estatística & dados numéricos , Espondilolistese/etiologia , Adolescente , Adulto , Baltimore/epidemiologia , Transplante Ósseo , Criança , Pré-Escolar , Progressão da Doença , Feminino , Humanos , Lactente , Síndrome de Loeys-Dietz/diagnóstico por imagem , Vértebras Lombares/cirurgia , Região Lombossacral/diagnóstico por imagem , Masculino , Complicações Pós-Operatórias , Prevalência , Pseudoartrose , Radiografia , Estudos Retrospectivos , Espondilolistese/diagnóstico por imagem , Espondilolistese/epidemiologia , Espondilolistese/cirurgia , Espondilólise , Resultado do Tratamento , Adulto Jovem
14.
J Strength Cond Res ; 31(6): 1662-1668, 2017 06.
Artigo em Inglês | MEDLINE | ID: mdl-28538318

RESUMO

There are 3 types of weapons used in Olympic fencing: the épée, foil, and sabre. The aim of this study was to determine if fencers exhibited different physical characteristics across weapons. Seventy-nine male (n = 46) and female (n = 33) national standard fencers took part in this study. Fencers from each weapon (male and female), i.e., épée (n = 19 and 10), foil (n = 22 and 14), and sabre (n = 13 and 10), were (mean ± SD) 15.9 ± 0.7 years of age, 178.5 ± 7.9 cm tall, 67.4 ± 12.2 kg in mass and had 6.3 ± 2.3 years fencing experience; all were in regular training (∼4 times per week). Results revealed that across all performance tests (lower-body power, reactive strength index, change of direction speed, and repeat lunge ability), there was no significant main effect for weapon in male fencers (p = 0.63) or female fencers (p = 0.232), but a significant main affect for gender (p < 0.001). Pairwise comparisons revealed that male fencers scored better during the countermovement jump, change of direction speed, and repeat lunge ability test (p < 0.001). The former findings may be because of similarities in bout intensity and time, movement types (lunging and changing direction), and the need to execute competition actions as explosively as possible. Based on the findings of the present study, it could be indicated that épée, foil, and sabre fencers do not require a weapon-specific approach to strength and conditioning training. Each fencer should target the area they are weakest at, rather than an area that they feel best represents the unique demands of their weapon.


Assuntos
Movimento/fisiologia , Treinamento Resistido/métodos , Esportes/fisiologia , Adolescente , Feminino , Humanos , Masculino , Fatores Sexuais , Armas
15.
Br J Hist Sci ; 50(3): 451-472, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28923130

RESUMO

In the mid-twentieth century film studios sent their screenplays to Hollywood's official censorship body, the Production Code Administration (PCA), and to the Catholic Church's Legion of Decency for approval and recommendations for revision. This article examines the negotiations between filmmakers and censorship groups in order to show the stories that censors did, and did not, want told about pregnancy, childbirth and abortion, as well as how studios fought to tell their own stories about human reproduction. I find that censors considered pregnancy to be a state of grace and a holy obligation that was restricted to married women. For censors, human reproduction was not only a private matter, it was also an unpleasant biological process whose entertainment value was questionable. They worried that realistic portrayals of pregnancy and childbirth would scare young women away from pursuing motherhood. In addition, I demonstrate how filmmakers overcame censors' strict prohibitions against abortion by utilizing ambiguity in their storytelling. Ultimately, I argue that censors believed that pregnancy and childbirth should be celebrated but not seen. But if pregnancy and childbirth were required then censors preferred mythic versions of motherhood instead of what they believed to be the sacred but horrific biological reality of human reproduction.


Assuntos
Aborto Induzido/história , Filmes Cinematográficos/história , Parto , Gravidez , Controle Social Formal , Aborto Induzido/legislação & jurisprudência , Catolicismo/história , Feminino , Regulamentação Governamental/história , História do Século XX , Humanos , Masculino , Princípios Morais , Filmes Cinematográficos/legislação & jurisprudência , Reprodução , Estados Unidos
16.
Proteomics ; 16(7): 1146-53, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-26834087

RESUMO

The iris is a fine structure that controls the amount of light that enters the eye. The ciliary body controls the shape of the lens and produces aqueous humor. The retinal pigment epithelium and choroid (RPE/choroid) are essential in supporting the retina and absorbing light energy that enters the eye. Proteins were extracted from iris, ciliary body, and RPE/choroid tissues of eyes from five individuals and fractionated using SDS-PAGE. After in-gel digestion, peptides were analyzed using LC-MS/MS on an Orbitrap Elite mass spectrometer. In iris, ciliary body, and RPE/choroid, we identified 2959, 2867, and 2755 nonredundant proteins with peptide and protein false-positive rates of <0.1% and <1%, respectively. Forty-three unambiguous protein isoforms were identified in iris, ciliary body, and RPE/choroid. Four "missing proteins" were identified in ciliary body based on ≥2 proteotypic peptides. The mass spectrometric proteome database of the human iris, ciliary body, and RPE/choroid may serve as a valuable resource for future investigations of the eye in health and disease. The MS proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifiers PXD001424 and PXD002194.


Assuntos
Proteínas do Olho/análise , Proteoma/análise , Epitélio Pigmentado da Retina/química , Úvea/química , Idoso , Eletroforese em Gel Bidimensional , Proteínas do Olho/química , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Proteoma/química , Proteômica
17.
J Emerg Nurs ; 41(5): 404-6, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-25819545

RESUMO

UNLABELLED: The body clock may, through stimulation of melatonin secretion, influence the Glasgow Coma Scale (GCS) score. The aim of this study was to investigate whether the time of presentation of children in the emergency department is associated with GCS scores. METHODS: We performed a retrospective review of 6,649 records of children presenting to an emergency department, with comparison of patients with GCS scores lower than 15 seen during the daytime and night time regarding diagnosis, disease severity, GCS score, age, sex, and ethnic group. RESULTS: Of 4,034 children seen during the daytime, 25 had GCS scores lower than 15, whereas 34 of 2,592 children seen during the night had GCS scores lower than 15 (P = .005). There were no differences in age, sex, ethnicity, or disease severity between the group of patients seen during the daytime and those seen during the night. Conditions presenting with reduced GCS scores were seizures (32%), respiratory tract infection (17%), other infections (20%), trauma (13%), and other conditions (18%). Significantly more children with respiratory tract infections and low GCS scores presented during the night (P = .029). DISCUSSION: The presentation of children with low GCS scores was more common during the night. Children with reduced GCS scores and viral respiratory tract infections presented more frequently during the night. Assessment of patients' level of consciousness during the night needs to discriminate difficulties in eliciting a response due to fatigue from features of cerebral dysfunction.


Assuntos
Relógios Biológicos , Ritmo Circadiano , Serviço Hospitalar de Emergência , Escala de Coma de Glasgow/estatística & dados numéricos , Fatores Etários , Criança , Feminino , Humanos , Masculino , Estudos Retrospectivos , Índice de Gravidade de Doença , Fatores Sexuais , Reino Unido
18.
Cureus ; 16(5): e60518, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38883029

RESUMO

Superficial acral fibromyxoma (SAFM) is a rare, slow-growing benign soft tissue tumor that is typically asymptomatic in nature and usually affects the acral regions of the hands and feet. The majority of these lesions are subungual. Excisional biopsy is the primary treatment modality. Despite the distinct clinical and histopathological features, misidentification of this slow-growing tumor persists. This case report contributes to the existing literature by delineating the clinicopathologic features, radiographic and MRI findings, and treatment strategies of SAFM.

19.
Bull Hosp Jt Dis (2013) ; 82(1): 53-59, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38431978

RESUMO

Ultrasound technologies are infrequently utilized in orthopedics as a first line diagnostic method, however, advances in technology and the applied techniques have opened the door for how and when ultrasound can be used. One specific avenue is the use of point of care ultrasound in which ultrasound is used at the time of initial patient evaluation by the evaluating physician. This use expedites time to diagnosis and can even guide therapeutic interventions. In the past two decades there have been numerous studies demonstrating the effectiveness of ultrasound for the diagnosis of many orthopedic conditions in the upper extremity, often demonstrating that it can be used in the place of and with greater diagnostic accuracy than magnetic resonance imaging. This review elaborates on these topics and lays a groundwork for how to incorporate point of care ultrasound into a modern orthopedic practice.


Assuntos
Doenças Musculoesqueléticas , Procedimentos Ortopédicos , Humanos , Sistemas Automatizados de Assistência Junto ao Leito , Ultrassonografia , Extremidade Superior/diagnóstico por imagem
20.
J Brachial Plex Peripher Nerve Inj ; 19(1): e13-e19, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-38868463

RESUMO

Background Brachial plexus birth injury results in deficits in strength and motion, occasionally requiring surgery to restore power to the deficient external rotators of the shoulder in these patients. This is a retrospective analysis of the long-term results of an isolated latissimus dorsi transfer to the rotator cuff in patients with brachial plexus birth injury. Methods This is a retrospective review of prospectively collected data for patients undergoing isolated latissimus dorsi transfer into the infraspinatus in addition to release of the internal rotation contracture of the shoulder with greater than 5 years' follow-up. Preoperative and postoperative shoulder elevation and external rotation were documented. Failure of surgery was defined as a return of the internal rotation contracture and a clinically apparent clarion sign. Results A total of 22 patients satisfied the inclusion criteria: 9 global palsies and 13 upper trunk palsies. The average follow-up was 11 years, ranging from 7.5 to 15.9 years. There was a trend for improved external rotation in the global palsy cohort at final follow-up ( p = 0.084). All nine global palsies maintained adequate external rotation without a clarion sign. Five of the 13 upper trunk palsies failed the latissimus dorsi transfer and subsequently required either teres major transfer and/or rotational osteotomy. In these five failures, the period from initial transfer to failure averaged 6.6 years, ranging from 3.4 to 9.5 years. Conclusion The results of this study indicate that patients with global palsy have sustained long-term improved outcomes with isolated latissimus dorsi transfer while patients with upper trunk palsy have a high rate of failure. Based on these results, we recommend isolated latissimus dorsi transfer for global palsy patients who have isolated infraspinatus weakness. Level of Evidence: Case series - Level IV.

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