Detalhe da pesquisa
1.
Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance.
J Mol Biol
; 284(2): 313-23, 1998 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-9813120
2.
The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance.
J Mol Biol
; 309(2): 437-45, 2001 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-11371163
3.
Absence of zidovudine resistance in antiretroviral-naive patients following zidovudine/lamivudine/protease inhibitor combination therapy: virological evaluation of the AVANTI 2 and AVANTI 3 studies.
AIDS
; 14(9): 1195-201, 2000 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-10894284
4.
Mutations in the non-nucleoside binding-pocket interfere with the multi-nucleoside resistance phenotype.
AIDS
; 15(5): 553-61, 2001 Mar 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-11316991
5.
Epidemiologically closely related viruses from hemophilia B patients display high homology in two hypervariable regions of the HIV-1 env gene.
AIDS Res Hum Retroviruses
; 7(4): 417-21, 1991 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-2069821
6.
Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors.
AIDS Res Hum Retroviruses
; 16(6): 517-28, 2000 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-10777142
7.
Diversification of HIV-1 strains after infection from a unique source.
AIDS Res Hum Retroviruses
; 9(2): 153-7, 1993 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-8457382
8.
Retention of marked sensitivity to (S)-4-isopropoxycarbonyl-6-methoxy-3-(methylthiomethyl)-3,4-di hydroquin oxaline-2(1H)-thione (HBY 097) by an azidothymidine (AZT)-resistant human immunodeficiency virus type 1 (HIV-1) strain subcultured in the combined presence of quinoxaline HBY 097 and 2',3'-dideoxy-3'-thiacytidine (lamivudine).
Biochem Pharmacol
; 55(5): 617-25, 1998 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-9515572
9.
GW420867X administered to HIV-1-infected patients alone and in combination with lamivudine and zidovudine.
HIV Clin Trials
; 2(4): 307-16, 2001.
Artigo
em Inglês
| MEDLINE | ID: mdl-11590533
10.
Reverse transcriptase fidelity and HIV-1 variation.
Science
; 275(5297): 229-30; author reply 230-1, 1997 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-8999551
11.
A related epitope is consistently present on glycoprotein C of herpes simplex virus type 1 and 2.
Acta Virol
; 35(3): 276-81, 1991 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-1719785
12.
Acute HIV-1 infection in patients with hemophilia B treated with beta-propiolactone-UV-inactivated clotting factor.
Thromb Haemost
; 64(2): 336-7, 1990 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-2125380
13.
Latent human herpesvirus-6 DNA is sparsely distributed in peripheral blood lymphocytes of healthy adults and patients with lymphocytic disorders.
Med Microbiol Immunol
; 180(3): 127-34, 1991.
Artigo
em Inglês
| MEDLINE | ID: mdl-1656178
14.
Detection of latent thymidine kinase-deficient herpes simplex virus in trigeminal ganglia of mice using the polymerase chain reaction.
Arch Virol
; 113(1-2): 107-13, 1990.
Artigo
em Inglês
| MEDLINE | ID: mdl-2167055
15.
Concomitant combination therapy for HIV infection preferable over sequential therapy with 3TC and non-nucleoside reverse transcriptase inhibitors.
Proc Natl Acad Sci U S A
; 93(23): 13152-7, 1996 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-8917560
16.
Mutational analysis of residue 190 of human immunodeficiency virus type 1 reverse transcriptase.
Virology
; 200(2): 696-701, 1994 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-7513921
17.
Inducible expression of herpes simplex virus type 1 glycoprotein C in NIH 3T3 cells.
Zentralbl Bakteriol
; 274(3): 426-32, 1990 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-1965287
18.
Rational dose selection for a nonnucleoside reverse transcriptase inhibitor through use of population pharmacokinetic modeling and Monte Carlo simulation.
Antimicrob Agents Chemother
; 46(3): 913-6, 2002 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-11850287
19.
Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74-->Val or Ile and Val-75-->Leu or Ile) HIV-1 mutants.
Proc Natl Acad Sci U S A
; 93(1): 34-8, 1996 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-8552634
20.
Absence of human immunodeficiency virus (HIV) proviral sequences in seronegative hemophilic men and sexual partners of HIV-seropositive hemophiliacs.
Transfusion
; 32(2): 104-8, 1992 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-1542915